Tags

Type your tag names separated by a space and hit enter

Focal and linear endocardial and epicardial catheter-based cryoablation of normal and infarcted ventricular tissue.
Pacing Clin Electrophysiol. 2008 Oct; 31(10):1322-31.PC

Abstract

BACKGROUND

This study of a chronic porcine postinfarction model examined whether linear epicardial cryoablation was capable of creating large, homogenous lesions in regions of the myocardium including scarred ventricle. Endocardial and epicardial focal cryolesions were also compared to determine if there were significant differences in lesion characteristics.

METHODS

Eighty focal endocardial and 28 focal epicardial cryoapplications were delivered to eight normal caprine and four normal porcine ventricular myocardium, and 21 linear cryolesions were applied along the border of infarcted epicardial tissue in a chronic porcine infarct model in six swines.

RESULTS

Focal endocardial cryolesions in normal animals measured 9.7+/-0.4 mm (length) by 7.3+/-1.4 mm (width) by 4.8+/-0.2 mm (depth), while epicardial lesions measured 10.2+/-1.4 mm (length) by 7.7+/-2 mm (width) by 4.6+/-0.9 mm (depth); P > 0.05. Linear epicardial cryolesions in the chronic porcine infarct model measured 36.5+/-7.8 mm (length) by 8.2+/-1.3 mm (width) by 6.0+/-1.2 mm (depth). The mean depth of linear cryolesions applied to the border of the infarct scar was 7+/-0.7 mm, as measured by magnetic resonance imaging.

CONCLUSIONS

Cryoablation can create deep lesions when delivered to the ventricular epicardium. Endocardial and epicardial cryolesions created by a focal cryoablation catheter are similar in size and depth. The ability to rapidly create deep linear cryolesions may prove to be beneficial in substrate-based catheter ablation of ventricular arrhythmias.

Links

Aggregator Full Text

Authors+Show Affiliations

D'Avila A
Cardiac Arrhythmia Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. adavila@med.miami.edu
Aryana A
No affiliation info available
Thiagalingam A
No affiliation info available
Holmvang G
No affiliation info available
Schmidt E
No affiliation info available
Gutierrez P
No affiliation info available
Ruskin JN
No affiliation info available
Reddy VY
No affiliation info available

MeSH

AnimalsCardiac CatheterizationCryosurgeryEndocardiumHeart VentriclesMyocardial InfarctionPericardiumSwineTreatment Outcome

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18811814

Citation

D'Avila, André, et al. "Focal and Linear Endocardial and Epicardial Catheter-based Cryoablation of Normal and Infarcted Ventricular Tissue." Pacing and Clinical Electrophysiology : PACE, vol. 31, no. 10, 2008, pp. 1322-31.
D'Avila A, Aryana A, Thiagalingam A, et al. Focal and linear endocardial and epicardial catheter-based cryoablation of normal and infarcted ventricular tissue. Pacing Clin Electrophysiol. 2008;31(10):1322-31.
D'Avila, A., Aryana, A., Thiagalingam, A., Holmvang, G., Schmidt, E., Gutierrez, P., Ruskin, J. N., & Reddy, V. Y. (2008). Focal and linear endocardial and epicardial catheter-based cryoablation of normal and infarcted ventricular tissue. Pacing and Clinical Electrophysiology : PACE, 31(10), 1322-31. https://doi.org/10.1111/j.1540-8159.2008.01184.x
D'Avila A, et al. Focal and Linear Endocardial and Epicardial Catheter-based Cryoablation of Normal and Infarcted Ventricular Tissue. Pacing Clin Electrophysiol. 2008;31(10):1322-31. PubMed PMID: 18811814.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Focal and linear endocardial and epicardial catheter-based cryoablation of normal and infarcted ventricular tissue. AU - D'Avila,André, AU - Aryana,Arash, AU - Thiagalingam,Aravinda, AU - Holmvang,Godtfred, AU - Schmidt,Ehud, AU - Gutierrez,Paulo, AU - Ruskin,Jeremy N, AU - Reddy,Vivek Y, PY - 2008/9/25/pubmed PY - 2008/12/17/medline PY - 2008/9/25/entrez SP - 1322 EP - 31 JF - Pacing and clinical electrophysiology : PACE JO - Pacing Clin Electrophysiol VL - 31 IS - 10 N2 - BACKGROUND: This study of a chronic porcine postinfarction model examined whether linear epicardial cryoablation was capable of creating large, homogenous lesions in regions of the myocardium including scarred ventricle. Endocardial and epicardial focal cryolesions were also compared to determine if there were significant differences in lesion characteristics. METHODS: Eighty focal endocardial and 28 focal epicardial cryoapplications were delivered to eight normal caprine and four normal porcine ventricular myocardium, and 21 linear cryolesions were applied along the border of infarcted epicardial tissue in a chronic porcine infarct model in six swines. RESULTS: Focal endocardial cryolesions in normal animals measured 9.7+/-0.4 mm (length) by 7.3+/-1.4 mm (width) by 4.8+/-0.2 mm (depth), while epicardial lesions measured 10.2+/-1.4 mm (length) by 7.7+/-2 mm (width) by 4.6+/-0.9 mm (depth); P > 0.05. Linear epicardial cryolesions in the chronic porcine infarct model measured 36.5+/-7.8 mm (length) by 8.2+/-1.3 mm (width) by 6.0+/-1.2 mm (depth). The mean depth of linear cryolesions applied to the border of the infarct scar was 7+/-0.7 mm, as measured by magnetic resonance imaging. CONCLUSIONS: Cryoablation can create deep lesions when delivered to the ventricular epicardium. Endocardial and epicardial cryolesions created by a focal cryoablation catheter are similar in size and depth. The ability to rapidly create deep linear cryolesions may prove to be beneficial in substrate-based catheter ablation of ventricular arrhythmias. SN - 1540-8159 UR - https://www.unboundmedicine.com/medline/citation/18811814/Focal_and_linear_endocardial_and_epicardial_catheter_based_cryoablation_of_normal_and_infarcted_ventricular_tissue_ L2 - https://doi.org/10.1111/j.1540-8159.2008.01184.x DB - PRIME DP - Unbound Medicine ER -