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Evaluation of sunscreen products using a reconstructed skin model exposed to simulated daily ultraviolet radiation: relevance of filtration profile and SPF value for daily photoprotection.
Photodermatol Photoimmunol Photomed. 2008 Oct; 24(5):249-55.PP

Abstract

BACKGROUND

The recent definition of a standard daily ultraviolet radiation (DUVR) has allowed us to reproduce non-zenithal sun exposure conditions. Exposure to simulated DUVR induces biological damage in human skin, suggesting the need for an appropriate photoprotection.

METHODS

Sunscreen products were evaluated using human reconstructed skin in vitro. Two commercial sunscreens (A and B) having similar sun (burn) protection factor (SPF) values (approximately 15) but different profiles of transmission over the UVA range were tested on skin models exposed to increasing doses of DUVR. Another pair of sunscreens was also tested. One (product C) had an SPF approximately 18 with a well-balanced UVB-UVA profile and the other (product D) an SPF of approximately 27 with low UVA absorption. Biological parameters were assessed by (i) histology, (ii) vimentin immunostaining for dermal fibroblasts, and (iii) analysis of matrix metalloprotease (MMP)-1 secretion.

RESULTS

Products A and C gave better protection from DUVR with regard to fibroblast alterations and MMP-1 release compared with products B and D, respectively.

CONCLUSION

To ensure an efficient daily photoprotection from DUVR, the filtration profile of the product should be well balanced with a sufficient level of UVA absorption. With regard to end points evaluated in this study, our data suggest that a higher SPF value does not compensate for low UVA filtration.

Authors+Show Affiliations

L'Oréal Recherche, Clichy, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18811866

Citation

Lejeune, François, et al. "Evaluation of Sunscreen Products Using a Reconstructed Skin Model Exposed to Simulated Daily Ultraviolet Radiation: Relevance of Filtration Profile and SPF Value for Daily Photoprotection." Photodermatology, Photoimmunology & Photomedicine, vol. 24, no. 5, 2008, pp. 249-55.
Lejeune F, Christiaens F, Bernerd F. Evaluation of sunscreen products using a reconstructed skin model exposed to simulated daily ultraviolet radiation: relevance of filtration profile and SPF value for daily photoprotection. Photodermatol Photoimmunol Photomed. 2008;24(5):249-55.
Lejeune, F., Christiaens, F., & Bernerd, F. (2008). Evaluation of sunscreen products using a reconstructed skin model exposed to simulated daily ultraviolet radiation: relevance of filtration profile and SPF value for daily photoprotection. Photodermatology, Photoimmunology & Photomedicine, 24(5), 249-55. https://doi.org/10.1111/j.1600-0781.2008.00370.x
Lejeune F, Christiaens F, Bernerd F. Evaluation of Sunscreen Products Using a Reconstructed Skin Model Exposed to Simulated Daily Ultraviolet Radiation: Relevance of Filtration Profile and SPF Value for Daily Photoprotection. Photodermatol Photoimmunol Photomed. 2008;24(5):249-55. PubMed PMID: 18811866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of sunscreen products using a reconstructed skin model exposed to simulated daily ultraviolet radiation: relevance of filtration profile and SPF value for daily photoprotection. AU - Lejeune,François, AU - Christiaens,François, AU - Bernerd,Françoise, PY - 2008/9/25/pubmed PY - 2008/12/17/medline PY - 2008/9/25/entrez SP - 249 EP - 55 JF - Photodermatology, photoimmunology & photomedicine JO - Photodermatol Photoimmunol Photomed VL - 24 IS - 5 N2 - BACKGROUND: The recent definition of a standard daily ultraviolet radiation (DUVR) has allowed us to reproduce non-zenithal sun exposure conditions. Exposure to simulated DUVR induces biological damage in human skin, suggesting the need for an appropriate photoprotection. METHODS: Sunscreen products were evaluated using human reconstructed skin in vitro. Two commercial sunscreens (A and B) having similar sun (burn) protection factor (SPF) values (approximately 15) but different profiles of transmission over the UVA range were tested on skin models exposed to increasing doses of DUVR. Another pair of sunscreens was also tested. One (product C) had an SPF approximately 18 with a well-balanced UVB-UVA profile and the other (product D) an SPF of approximately 27 with low UVA absorption. Biological parameters were assessed by (i) histology, (ii) vimentin immunostaining for dermal fibroblasts, and (iii) analysis of matrix metalloprotease (MMP)-1 secretion. RESULTS: Products A and C gave better protection from DUVR with regard to fibroblast alterations and MMP-1 release compared with products B and D, respectively. CONCLUSION: To ensure an efficient daily photoprotection from DUVR, the filtration profile of the product should be well balanced with a sufficient level of UVA absorption. With regard to end points evaluated in this study, our data suggest that a higher SPF value does not compensate for low UVA filtration. SN - 1600-0781 UR - https://www.unboundmedicine.com/medline/citation/18811866/Evaluation_of_sunscreen_products_using_a_reconstructed_skin_model_exposed_to_simulated_daily_ultraviolet_radiation:_relevance_of_filtration_profile_and_SPF_value_for_daily_photoprotection_ L2 - https://doi.org/10.1111/j.1600-0781.2008.00370.x DB - PRIME DP - Unbound Medicine ER -