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Frequency and genotype of GB virus C among Iranian patients infected with HIV.
J Med Virol. 2008 Nov; 80(11):1941-6.JM

Abstract

GB virus C (GBV-C) infection is frequent in patients infected with the human immunodeficiency virus (HIV) due to similar transmission routes of these viruses. The aim of this study was to determine the rate of infection and genotypic characteristics of GBV-C in this population. The presence of GBV-C RNA was determined in serum samples of 106 patients infected with HIV by reverse transcriptase-nested polymerase chain reaction. GBV-C genotypes were determined by direct sequencing. Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), hepatitis C antibody (anti-HCV), alanine aminotransferase (ALT) levels, HIV viral load and CD4(+) count were also tested in all patients. The overall prevalence of GBV-C infection was 11.3% in HIV patients. There was no significant difference between patients with and without GBV-C infection regarding age, sex, route of transmission, viral load, ALT levels, HBV and HCV co-infection and treatment with antiretroviral drugs. 66.7% of patients with GBV-C had a CD4(+) count > or = 200 and 33.3% had a CD4(+) count < 200 cells/mm(3). Phylogenetic analysis revealed that all GBV-C isolates were genotype 2, and classified as subtype 2a. GBV-C infection is relatively common in patients infected with HIV. The prevailing GBV-C genotype 2a in this study group concurred with reports from other parts of the Middle East.

Authors+Show Affiliations

Hepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18814233

Citation

Hekmat, Soheila, et al. "Frequency and Genotype of GB Virus C Among Iranian Patients Infected With HIV." Journal of Medical Virology, vol. 80, no. 11, 2008, pp. 1941-6.
Hekmat S, Mohraz M, Vahabpour R, et al. Frequency and genotype of GB virus C among Iranian patients infected with HIV. J Med Virol. 2008;80(11):1941-6.
Hekmat, S., Mohraz, M., Vahabpour, R., Jam, S., Bahramali, G., Banifazl, M., Aghakhani, A., Eslamifar, A., Mahboudi, F., Edalat, R., & Ramezani, A. (2008). Frequency and genotype of GB virus C among Iranian patients infected with HIV. Journal of Medical Virology, 80(11), 1941-6. https://doi.org/10.1002/jmv.21314
Hekmat S, et al. Frequency and Genotype of GB Virus C Among Iranian Patients Infected With HIV. J Med Virol. 2008;80(11):1941-6. PubMed PMID: 18814233.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency and genotype of GB virus C among Iranian patients infected with HIV. AU - Hekmat,Soheila, AU - Mohraz,Minoo, AU - Vahabpour,Rouhollah, AU - Jam,Sara, AU - Bahramali,Golnaz, AU - Banifazl,Mohammad, AU - Aghakhani,Arezoo, AU - Eslamifar,Ali, AU - Mahboudi,Fereidoun, AU - Edalat,Rozita, AU - Ramezani,Amitis, PY - 2008/9/25/pubmed PY - 2008/10/28/medline PY - 2008/9/25/entrez SP - 1941 EP - 6 JF - Journal of medical virology JO - J Med Virol VL - 80 IS - 11 N2 - GB virus C (GBV-C) infection is frequent in patients infected with the human immunodeficiency virus (HIV) due to similar transmission routes of these viruses. The aim of this study was to determine the rate of infection and genotypic characteristics of GBV-C in this population. The presence of GBV-C RNA was determined in serum samples of 106 patients infected with HIV by reverse transcriptase-nested polymerase chain reaction. GBV-C genotypes were determined by direct sequencing. Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), hepatitis C antibody (anti-HCV), alanine aminotransferase (ALT) levels, HIV viral load and CD4(+) count were also tested in all patients. The overall prevalence of GBV-C infection was 11.3% in HIV patients. There was no significant difference between patients with and without GBV-C infection regarding age, sex, route of transmission, viral load, ALT levels, HBV and HCV co-infection and treatment with antiretroviral drugs. 66.7% of patients with GBV-C had a CD4(+) count > or = 200 and 33.3% had a CD4(+) count < 200 cells/mm(3). Phylogenetic analysis revealed that all GBV-C isolates were genotype 2, and classified as subtype 2a. GBV-C infection is relatively common in patients infected with HIV. The prevailing GBV-C genotype 2a in this study group concurred with reports from other parts of the Middle East. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/18814233/Frequency_and_genotype_of_GB_virus_C_among_Iranian_patients_infected_with_HIV_ L2 - https://doi.org/10.1002/jmv.21314 DB - PRIME DP - Unbound Medicine ER -