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Regulatory role of NKp44, NKp46, DNAM-1 and NKG2D receptors in the interaction between NK cells and trophoblast cells. Evidence for divergent functional profiles of decidual versus peripheral NK cells.
Int Immunol. 2008 Nov; 20(11):1395-405.II

Abstract

During the first trimester of pregnancy NK cells represent >50% of the lymphoid cells present in the human decidua where they reside in close contact with trophoblast cells. Because in decidual tissues NK cell activation and function may be induced by this interaction, we analyzed the cellular ligands recognized by activating NK receptors expressed on trophoblast cells. We show that these cells primarily express the NKp44 and DNAM-1 ligands and that interaction between these ligands and their corresponding receptors results in NK cell triggering. While activated peripheral blood NK (pNK) cells lysed the trophoblast cell lines JAR and JEG3, decidual NK (dNK) cells did not. On the other hand, they released VEGF, SDF-1, IP10 and large amounts of IL-8. Interaction with K562 target cells was exploited to induce optimal NK cell triggering, allowing a parallel, quantitative assessment of both cytolytic activity and cytokine production elicited by dNK cells. While dNK cells were unable to kill K562 even at high effector:target (E:T) ratios, they released large amounts of IL-8 also at low E:T ratios, a scenario compatible with dNK trophoblast cells interaction occurring within decidual tissues.

Authors+Show Affiliations

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genova, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18815119

Citation

Vacca, Paola, et al. "Regulatory Role of NKp44, NKp46, DNAM-1 and NKG2D Receptors in the Interaction Between NK Cells and Trophoblast Cells. Evidence for Divergent Functional Profiles of Decidual Versus Peripheral NK Cells." International Immunology, vol. 20, no. 11, 2008, pp. 1395-405.
Vacca P, Cantoni C, Prato C, et al. Regulatory role of NKp44, NKp46, DNAM-1 and NKG2D receptors in the interaction between NK cells and trophoblast cells. Evidence for divergent functional profiles of decidual versus peripheral NK cells. Int Immunol. 2008;20(11):1395-405.
Vacca, P., Cantoni, C., Prato, C., Fulcheri, E., Moretta, A., Moretta, L., & Mingari, M. C. (2008). Regulatory role of NKp44, NKp46, DNAM-1 and NKG2D receptors in the interaction between NK cells and trophoblast cells. Evidence for divergent functional profiles of decidual versus peripheral NK cells. International Immunology, 20(11), 1395-405. https://doi.org/10.1093/intimm/dxn105
Vacca P, et al. Regulatory Role of NKp44, NKp46, DNAM-1 and NKG2D Receptors in the Interaction Between NK Cells and Trophoblast Cells. Evidence for Divergent Functional Profiles of Decidual Versus Peripheral NK Cells. Int Immunol. 2008;20(11):1395-405. PubMed PMID: 18815119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulatory role of NKp44, NKp46, DNAM-1 and NKG2D receptors in the interaction between NK cells and trophoblast cells. Evidence for divergent functional profiles of decidual versus peripheral NK cells. AU - Vacca,Paola, AU - Cantoni,Claudia, AU - Prato,Carola, AU - Fulcheri,Ezio, AU - Moretta,Alessandro, AU - Moretta,Lorenzo, AU - Mingari,Maria Cristina, Y1 - 2008/09/23/ PY - 2008/9/26/pubmed PY - 2009/8/6/medline PY - 2008/9/26/entrez SP - 1395 EP - 405 JF - International immunology JO - Int. Immunol. VL - 20 IS - 11 N2 - During the first trimester of pregnancy NK cells represent >50% of the lymphoid cells present in the human decidua where they reside in close contact with trophoblast cells. Because in decidual tissues NK cell activation and function may be induced by this interaction, we analyzed the cellular ligands recognized by activating NK receptors expressed on trophoblast cells. We show that these cells primarily express the NKp44 and DNAM-1 ligands and that interaction between these ligands and their corresponding receptors results in NK cell triggering. While activated peripheral blood NK (pNK) cells lysed the trophoblast cell lines JAR and JEG3, decidual NK (dNK) cells did not. On the other hand, they released VEGF, SDF-1, IP10 and large amounts of IL-8. Interaction with K562 target cells was exploited to induce optimal NK cell triggering, allowing a parallel, quantitative assessment of both cytolytic activity and cytokine production elicited by dNK cells. While dNK cells were unable to kill K562 even at high effector:target (E:T) ratios, they released large amounts of IL-8 also at low E:T ratios, a scenario compatible with dNK trophoblast cells interaction occurring within decidual tissues. SN - 1460-2377 UR - https://www.unboundmedicine.com/medline/citation/18815119/Regulatory_role_of_NKp44_NKp46_DNAM_1_and_NKG2D_receptors_in_the_interaction_between_NK_cells_and_trophoblast_cells__Evidence_for_divergent_functional_profiles_of_decidual_versus_peripheral_NK_cells_ L2 - https://academic.oup.com/intimm/article-lookup/doi/10.1093/intimm/dxn105 DB - PRIME DP - Unbound Medicine ER -