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Biological mediators of effect of diet and stress reduction on prostate cancer.
Integr Cancer Ther 2008; 7(3):130-8IC

Abstract

BACKGROUND

A 6-month pilot intervention trial was conducted to determine whether adoption of a plant-based diet, reinforced by stress reduction, could reduce the rate of prostate-specific antigen (PSA) increase, a marker of disease progression, in asymptomatic, hormonally untreated patients experiencing consistently increasing PSA levels after surgery or radiation.

METHODS

A pre-post design was used to examine (1) the effect of intervention on potential mediators of disease progression, including body composition and weight-related biomarkers (sex steroid hormones and cytokines), and (2) whether changes in these variables were associated with change in rate of PSA increase. The baseline rate of PSA increase (from the time of posttreatment recurrence to the start of intervention) was ascertained from medical records. Body composition and biomarkers were assessed at baseline (prior to intervention), during the intervention (3 months), and at the end of the intervention (6 months). Changes in body composition and biomarkers were determined and compared with rates of PSA increase over the corresponding time intervals.

RESULTS

There was a significant reduction in waist-to-hip ratio (P=.03) and increase in circulating sex hormone binding globulin (P=.04). The rate of PSA increase decreased from the preintervention period (PSA slope=0.059) to the period from 0 to 3 months (PSA slope=0.002, P<.01) and increased slightly, although not significantly, from 0 to 3 months to the period from 3 to 6 months (0.029, P=.43).

CONCLUSIONS

Adoption of a plant-based diet and stress reduction may reduce central adiposity and improve the hormonal milieu in patients with recurrent PC. Changes in the rate of increase in PSA were in the same direction as changes in waist-to-hip ratio and opposite those of sex hormone binding globulin, raising the possibility that the effect of the intervention may have been mediated, in part, by these variables.

Authors+Show Affiliations

Department of Family and Preventive Medicine, University of California, San Diego, Moores UCSD Cancer Center, San Diego, La Jolla, California 92093-0901, USA. gsaxe@ucsd.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18815144

Citation

Saxe, Gordon A., et al. "Biological Mediators of Effect of Diet and Stress Reduction On Prostate Cancer." Integrative Cancer Therapies, vol. 7, no. 3, 2008, pp. 130-8.
Saxe GA, Major JM, Westerberg L, et al. Biological mediators of effect of diet and stress reduction on prostate cancer. Integr Cancer Ther. 2008;7(3):130-8.
Saxe, G. A., Major, J. M., Westerberg, L., Khandrika, S., & Downs, T. M. (2008). Biological mediators of effect of diet and stress reduction on prostate cancer. Integrative Cancer Therapies, 7(3), pp. 130-8. doi:10.1177/1534735408322849.
Saxe GA, et al. Biological Mediators of Effect of Diet and Stress Reduction On Prostate Cancer. Integr Cancer Ther. 2008;7(3):130-8. PubMed PMID: 18815144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biological mediators of effect of diet and stress reduction on prostate cancer. AU - Saxe,Gordon A, AU - Major,Jacqueline M, AU - Westerberg,Lindsey, AU - Khandrika,Srikrishna, AU - Downs,Tracy M, PY - 2008/9/26/pubmed PY - 2009/1/14/medline PY - 2008/9/26/entrez SP - 130 EP - 8 JF - Integrative cancer therapies JO - Integr Cancer Ther VL - 7 IS - 3 N2 - BACKGROUND: A 6-month pilot intervention trial was conducted to determine whether adoption of a plant-based diet, reinforced by stress reduction, could reduce the rate of prostate-specific antigen (PSA) increase, a marker of disease progression, in asymptomatic, hormonally untreated patients experiencing consistently increasing PSA levels after surgery or radiation. METHODS: A pre-post design was used to examine (1) the effect of intervention on potential mediators of disease progression, including body composition and weight-related biomarkers (sex steroid hormones and cytokines), and (2) whether changes in these variables were associated with change in rate of PSA increase. The baseline rate of PSA increase (from the time of posttreatment recurrence to the start of intervention) was ascertained from medical records. Body composition and biomarkers were assessed at baseline (prior to intervention), during the intervention (3 months), and at the end of the intervention (6 months). Changes in body composition and biomarkers were determined and compared with rates of PSA increase over the corresponding time intervals. RESULTS: There was a significant reduction in waist-to-hip ratio (P=.03) and increase in circulating sex hormone binding globulin (P=.04). The rate of PSA increase decreased from the preintervention period (PSA slope=0.059) to the period from 0 to 3 months (PSA slope=0.002, P<.01) and increased slightly, although not significantly, from 0 to 3 months to the period from 3 to 6 months (0.029, P=.43). CONCLUSIONS: Adoption of a plant-based diet and stress reduction may reduce central adiposity and improve the hormonal milieu in patients with recurrent PC. Changes in the rate of increase in PSA were in the same direction as changes in waist-to-hip ratio and opposite those of sex hormone binding globulin, raising the possibility that the effect of the intervention may have been mediated, in part, by these variables. SN - 1534-7354 UR - https://www.unboundmedicine.com/medline/citation/18815144/Biological_mediators_of_effect_of_diet_and_stress_reduction_on_prostate_cancer_ L2 - http://journals.sagepub.com/doi/full/10.1177/1534735408322849?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -