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Granulosa cell tumor of the ovary: tumor review.
Integr Cancer Ther 2008; 7(3):204-15IC

Abstract

Granulosa cell tumors of the ovary are rare neoplasms that originate from sex-cord stromal cells. The long natural history of granulosa cell tumors and their tendency to recur years after the initial diagnosis are the most prominent of their characteristics. The secretion of estradiol is the reason for signs at presentation such as vaginal bleeding and precocious puberty. Abdominal pain and hemoperitoneum, which occasionally can occur, are attributable to tumor rupture. The most common finding in pelvic examination is a tumor mass, which is subsequently confirmed with imaging techniques. Surgery is the mainstay of initial management for histological diagnosis, appropriate staging, and debulking. A more conservative unilateral salpingo-oophorectomy is indicated in patients with stage I disease and patients of reproductive age. Total abdominal hysterectomy with bilateral salpingo-oophorectomy is the appropriate surgical treatment for postmenopausal women and those with more advanced disease. The stage of disease is the most important prognostic factor associated with the risk of relapse. There are no clear conclusions regarding the role of postoperative chemotherapy or radiotherapy in stage I disease and in those with completely resected tumor. The use of adjuvant chemotherapy or radiotherapy has sometimes been associated with prolonged disease-free survival and possibly overall survival. Chemotherapy is the treatment of choice for patients with advanced, recurrent, or metastatic disease, and BEP (bleomycin, etoposide, and cisplatin) is the preferred regimen. Although the overall rate of response to treatment is high, the impact of treatment on disease-free or overall survival is unknown. Prolonged surveillance is mandatory because tumors tend to recur years after the initial diagnosis.

Authors+Show Affiliations

University of Ahepa Medical School, 2nd Department of Radiology, Radiation Therapy Unit, Attikon University Hospital, Greece. gkoyokoyrakis@yahoo.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18815151

Citation

Koukourakis, Georgios V., et al. "Granulosa Cell Tumor of the Ovary: Tumor Review." Integrative Cancer Therapies, vol. 7, no. 3, 2008, pp. 204-15.
Koukourakis GV, Kouloulias VE, Koukourakis MJ, et al. Granulosa cell tumor of the ovary: tumor review. Integr Cancer Ther. 2008;7(3):204-15.
Koukourakis, G. V., Kouloulias, V. E., Koukourakis, M. J., Zacharias, G. A., Papadimitriou, C., Mystakidou, K., ... Gouliamos, A. (2008). Granulosa cell tumor of the ovary: tumor review. Integrative Cancer Therapies, 7(3), pp. 204-15. doi:10.1177/1534735408322845.
Koukourakis GV, et al. Granulosa Cell Tumor of the Ovary: Tumor Review. Integr Cancer Ther. 2008;7(3):204-15. PubMed PMID: 18815151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Granulosa cell tumor of the ovary: tumor review. AU - Koukourakis,Georgios V, AU - Kouloulias,Vasilios E, AU - Koukourakis,Michael J, AU - Zacharias,Georgios A, AU - Papadimitriou,Christos, AU - Mystakidou,Kyriaki, AU - Pistevou-Gompaki,Kyriaki, AU - Kouvaris,John, AU - Gouliamos,Athanasios, PY - 2008/9/26/pubmed PY - 2009/1/14/medline PY - 2008/9/26/entrez SP - 204 EP - 15 JF - Integrative cancer therapies JO - Integr Cancer Ther VL - 7 IS - 3 N2 - Granulosa cell tumors of the ovary are rare neoplasms that originate from sex-cord stromal cells. The long natural history of granulosa cell tumors and their tendency to recur years after the initial diagnosis are the most prominent of their characteristics. The secretion of estradiol is the reason for signs at presentation such as vaginal bleeding and precocious puberty. Abdominal pain and hemoperitoneum, which occasionally can occur, are attributable to tumor rupture. The most common finding in pelvic examination is a tumor mass, which is subsequently confirmed with imaging techniques. Surgery is the mainstay of initial management for histological diagnosis, appropriate staging, and debulking. A more conservative unilateral salpingo-oophorectomy is indicated in patients with stage I disease and patients of reproductive age. Total abdominal hysterectomy with bilateral salpingo-oophorectomy is the appropriate surgical treatment for postmenopausal women and those with more advanced disease. The stage of disease is the most important prognostic factor associated with the risk of relapse. There are no clear conclusions regarding the role of postoperative chemotherapy or radiotherapy in stage I disease and in those with completely resected tumor. The use of adjuvant chemotherapy or radiotherapy has sometimes been associated with prolonged disease-free survival and possibly overall survival. Chemotherapy is the treatment of choice for patients with advanced, recurrent, or metastatic disease, and BEP (bleomycin, etoposide, and cisplatin) is the preferred regimen. Although the overall rate of response to treatment is high, the impact of treatment on disease-free or overall survival is unknown. Prolonged surveillance is mandatory because tumors tend to recur years after the initial diagnosis. SN - 1534-7354 UR - https://www.unboundmedicine.com/medline/citation/18815151/Granulosa_cell_tumor_of_the_ovary:_tumor_review_ L2 - http://journals.sagepub.com/doi/full/10.1177/1534735408322845?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -