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Association of visceral and subcutaneous adiposity with kidney function.
Clin J Am Soc Nephrol 2008; 3(6):1786-91CJ

Abstract

BACKGROUND AND OBJECTIVES

Obesity is a risk factor for incident chronic kidney disease (CKD). Visceral (VAT) and subcutaneous adipose tissue (SAT) may confer differential metabolic risk profiles. The relations of VAT and SAT were analyzed with CKD as estimated by creatinine- and cystatin-based estimating equations.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS

Participants from the Framingham Offspring Study who underwent abdominal computed tomography for VAT and SAT quantification were included (n = 1299; 53% women; mean age 60 yr). CKD was defined as estimated GFR <60 ml/min per 1.73 m(2), as estimated using creatinine (n = 89) in the Modification of Diet in Renal Disease (MDRD) formula or by cystatin C (n = 136). Regression models evaluated the cross-sectional relations between VAT and SAT with CKD and cystatin C, with age and gender adjustment and cardiovascular risk factor adjustment.

RESULTS

Neither VAT nor SAT was associated with CKD as estimated by the MDRD equation. In contrast, both VAT and SAT were associated with CKD when defined using cystatin-based equations. The estimated decrease in estimated GFR by cystatin C per 1-SD increase of VAT was 1.9 ml/min per 1.73 m(2) and for SAT was 2.6 ml/min per 1.73 m(2) in a multivariable-adjusted model.

CONCLUSIONS

VAT and SAT were associated with CKD when defined using cystatin C estimating equations but not when using a creatinine-based estimating equation. Mechanisms linking adipose tissue to cystatin C warrant further research.

Authors+Show Affiliations

Tufts-New England Medical Center, Boston, Massachusetts, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18815239

Citation

Young, Jill A., et al. "Association of Visceral and Subcutaneous Adiposity With Kidney Function." Clinical Journal of the American Society of Nephrology : CJASN, vol. 3, no. 6, 2008, pp. 1786-91.
Young JA, Hwang SJ, Sarnak MJ, et al. Association of visceral and subcutaneous adiposity with kidney function. Clin J Am Soc Nephrol. 2008;3(6):1786-91.
Young, J. A., Hwang, S. J., Sarnak, M. J., Hoffmann, U., Massaro, J. M., Levy, D., ... Fox, C. S. (2008). Association of visceral and subcutaneous adiposity with kidney function. Clinical Journal of the American Society of Nephrology : CJASN, 3(6), pp. 1786-91. doi:10.2215/CJN.02490508.
Young JA, et al. Association of Visceral and Subcutaneous Adiposity With Kidney Function. Clin J Am Soc Nephrol. 2008;3(6):1786-91. PubMed PMID: 18815239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of visceral and subcutaneous adiposity with kidney function. AU - Young,Jill A, AU - Hwang,Shih-Jen, AU - Sarnak,Mark J, AU - Hoffmann,Udo, AU - Massaro,Joseph M, AU - Levy,Daniel, AU - Benjamin,Emelia J, AU - Larson,Martin G, AU - Vasan,Ramachandran S, AU - O'Donnell,Christopher J, AU - Fox,Caroline S, Y1 - 2008/09/24/ PY - 2008/9/26/pubmed PY - 2009/1/7/medline PY - 2008/9/26/entrez SP - 1786 EP - 91 JF - Clinical journal of the American Society of Nephrology : CJASN JO - Clin J Am Soc Nephrol VL - 3 IS - 6 N2 - BACKGROUND AND OBJECTIVES: Obesity is a risk factor for incident chronic kidney disease (CKD). Visceral (VAT) and subcutaneous adipose tissue (SAT) may confer differential metabolic risk profiles. The relations of VAT and SAT were analyzed with CKD as estimated by creatinine- and cystatin-based estimating equations. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Participants from the Framingham Offspring Study who underwent abdominal computed tomography for VAT and SAT quantification were included (n = 1299; 53% women; mean age 60 yr). CKD was defined as estimated GFR <60 ml/min per 1.73 m(2), as estimated using creatinine (n = 89) in the Modification of Diet in Renal Disease (MDRD) formula or by cystatin C (n = 136). Regression models evaluated the cross-sectional relations between VAT and SAT with CKD and cystatin C, with age and gender adjustment and cardiovascular risk factor adjustment. RESULTS: Neither VAT nor SAT was associated with CKD as estimated by the MDRD equation. In contrast, both VAT and SAT were associated with CKD when defined using cystatin-based equations. The estimated decrease in estimated GFR by cystatin C per 1-SD increase of VAT was 1.9 ml/min per 1.73 m(2) and for SAT was 2.6 ml/min per 1.73 m(2) in a multivariable-adjusted model. CONCLUSIONS: VAT and SAT were associated with CKD when defined using cystatin C estimating equations but not when using a creatinine-based estimating equation. Mechanisms linking adipose tissue to cystatin C warrant further research. SN - 1555-905X UR - https://www.unboundmedicine.com/medline/citation/18815239/Association_of_visceral_and_subcutaneous_adiposity_with_kidney_function_ L2 - http://cjasn.asnjournals.org/cgi/pmidlookup?view=long&amp;pmid=18815239 DB - PRIME DP - Unbound Medicine ER -