Tags

Type your tag names separated by a space and hit enter

[The clinico-instrumental evaluation of the efficacy of picotamide in treating chronic obstructive arteriopathies of the lower extremities].
Minerva Cardioangiol. 1991 Mar; 39(3):75-80.MC

Abstract

In 25 patients (19 males and 6 females) suffering from chronic arteriopathy of lower extremities at Fontaine stage II, the clinical efficacy of picotamide was investigated in double blind, cross over placebo-controlled study. Patients were assigned randomly to the treatment with placebo or picotamide (900 mg/die) for three months and, after 15 days of wash-out, to the treatment with picotamide or placebo for the same period. Painfree walking distance and ankle/arm systolic pressure ratio improved significantly only during picotamide treatment. Laboratory monitoring revealed a significant decrease in platelet aggregation and an increase of fibrinogen degradation products only during picotamide treatment. Three patients during picotamide treatment referred transient gastrointestinal discomfort (nausea, vomiting and diarrhoea); however in no case the treatment was suspended because of the appearance of these symptoms. These results indicate that picotamide is an effective drug in the management of chronic arteriopathy of lower extremities.

Authors+Show Affiliations

II Facoltà di Medicina e Chirurgia, Cattedra di Geriatria, Università degli Studi di Napoli.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial

Language

ita

PubMed ID

1881558

Citation

Canonico, V, et al. "[The Clinico-instrumental Evaluation of the Efficacy of Picotamide in Treating Chronic Obstructive Arteriopathies of the Lower Extremities]." Minerva Cardioangiologica, vol. 39, no. 3, 1991, pp. 75-80.
Canonico V, Ammaturo V, Guarini P, et al. [The clinico-instrumental evaluation of the efficacy of picotamide in treating chronic obstructive arteriopathies of the lower extremities]. Minerva Cardioangiol. 1991;39(3):75-80.
Canonico, V., Ammaturo, V., Guarini, P., Tedeschi, C., Nunziata, G., Nappi, A., Forgione, L., & Rengo, F. (1991). [The clinico-instrumental evaluation of the efficacy of picotamide in treating chronic obstructive arteriopathies of the lower extremities]. Minerva Cardioangiologica, 39(3), 75-80.
Canonico V, et al. [The Clinico-instrumental Evaluation of the Efficacy of Picotamide in Treating Chronic Obstructive Arteriopathies of the Lower Extremities]. Minerva Cardioangiol. 1991;39(3):75-80. PubMed PMID: 1881558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The clinico-instrumental evaluation of the efficacy of picotamide in treating chronic obstructive arteriopathies of the lower extremities]. AU - Canonico,V, AU - Ammaturo,V, AU - Guarini,P, AU - Tedeschi,C, AU - Nunziata,G, AU - Nappi,A, AU - Forgione,L, AU - Rengo,F, PY - 1991/3/1/pubmed PY - 1991/3/1/medline PY - 1991/3/1/entrez SP - 75 EP - 80 JF - Minerva cardioangiologica JO - Minerva Cardioangiol VL - 39 IS - 3 N2 - In 25 patients (19 males and 6 females) suffering from chronic arteriopathy of lower extremities at Fontaine stage II, the clinical efficacy of picotamide was investigated in double blind, cross over placebo-controlled study. Patients were assigned randomly to the treatment with placebo or picotamide (900 mg/die) for three months and, after 15 days of wash-out, to the treatment with picotamide or placebo for the same period. Painfree walking distance and ankle/arm systolic pressure ratio improved significantly only during picotamide treatment. Laboratory monitoring revealed a significant decrease in platelet aggregation and an increase of fibrinogen degradation products only during picotamide treatment. Three patients during picotamide treatment referred transient gastrointestinal discomfort (nausea, vomiting and diarrhoea); however in no case the treatment was suspended because of the appearance of these symptoms. These results indicate that picotamide is an effective drug in the management of chronic arteriopathy of lower extremities. SN - 0026-4725 UR - https://www.unboundmedicine.com/medline/citation/1881558/[The_clinico_instrumental_evaluation_of_the_efficacy_of_picotamide_in_treating_chronic_obstructive_arteriopathies_of_the_lower_extremities]_ L2 - https://medlineplus.gov/bloodthinners.html DB - PRIME DP - Unbound Medicine ER -