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Diurnal variation in urinary protein excretion in diabetic nephropathy.
Nephrol Dial Transplant. 1991; 6(4):238-43.ND

Abstract

We examined the diurnal variation in urinary excretion rate of albumin, IgG and beta 2-Microglobulin (beta 2-M) in healthy volunteers (n = 24), and in patients with type I diabetes mellitus having normal albumin excretion rate (less than 20 micrograms/min; n = 16), incipient diabetic nephropathy (albumin excretion rate 20-200 micrograms/min; n = 12) and clinical diabetic nephropathy (albumin excretion rate greater than 200 micrograms/min; n = 12). Diurnal variation was defined as [(overnight minus daytime): daytime excretion rate] times 100%. Median diurnal variation in albumin excretion rate in the various groups varied from -32 to -57%, and in IgG excretion rate from -42 to -65%, being not significantly different between the proteins or between the groups. Diurnal variation in beta 2-M excretion rate was similar in healthy volunteers and in patients with normal albumin excretion rate or incipient diabetic nephropathy (median -36 to -43%), but significantly reduced in patients with clinical diabetic nephropathy (median 0%; P less than 0.005), nine of whom had elevated beta 2-M excretion rates, suggesting tubular dysfunction. Except for beta 2-M excretion rate in patients with clinical diabetic nephropathy, the diurnal variations in albumin excretion rate, IgG excretion rate and beta 2-M excretion rate were larger than the diurnal variation in creatinine excretion rate (median -7 to -11%, P less than 0.005). Diurnal variations in albumin excretion rate and IgG excretion rate were highly correlated (r = 0.89, P less than 0.00001). These data suggest that similar mechanisms may account for diurnal variations in albumin excretion rate and IgG excretion rate.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Stehouwer CD
Department of Internal Medicine, Bergweg Municipal Hospital, Rotterdam, The Netherlands.
Fischer HR
No affiliation info available
Hackeng WH
No affiliation info available
den Ottolander GJ
No affiliation info available
Donker AJ
No affiliation info available

MeSH

AdultAlbuminuriaCircadian RhythmCreatinineDiabetes Mellitus, Type 1Diabetic NephropathiesFemaleHumansImmunoglobulin GMaleProteinuriabeta 2-Microglobulin

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1881577

Citation

Stehouwer, C D., et al. "Diurnal Variation in Urinary Protein Excretion in Diabetic Nephropathy." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 6, no. 4, 1991, pp. 238-43.
Stehouwer CD, Fischer HR, Hackeng WH, et al. Diurnal variation in urinary protein excretion in diabetic nephropathy. Nephrol Dial Transplant. 1991;6(4):238-43.
Stehouwer, C. D., Fischer, H. R., Hackeng, W. H., den Ottolander, G. J., & Donker, A. J. (1991). Diurnal variation in urinary protein excretion in diabetic nephropathy. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 6(4), 238-43.
Stehouwer CD, et al. Diurnal Variation in Urinary Protein Excretion in Diabetic Nephropathy. Nephrol Dial Transplant. 1991;6(4):238-43. PubMed PMID: 1881577.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diurnal variation in urinary protein excretion in diabetic nephropathy. AU - Stehouwer,C D, AU - Fischer,H R, AU - Hackeng,W H, AU - den Ottolander,G J, AU - Donker,A J, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 238 EP - 43 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 6 IS - 4 N2 - We examined the diurnal variation in urinary excretion rate of albumin, IgG and beta 2-Microglobulin (beta 2-M) in healthy volunteers (n = 24), and in patients with type I diabetes mellitus having normal albumin excretion rate (less than 20 micrograms/min; n = 16), incipient diabetic nephropathy (albumin excretion rate 20-200 micrograms/min; n = 12) and clinical diabetic nephropathy (albumin excretion rate greater than 200 micrograms/min; n = 12). Diurnal variation was defined as [(overnight minus daytime): daytime excretion rate] times 100%. Median diurnal variation in albumin excretion rate in the various groups varied from -32 to -57%, and in IgG excretion rate from -42 to -65%, being not significantly different between the proteins or between the groups. Diurnal variation in beta 2-M excretion rate was similar in healthy volunteers and in patients with normal albumin excretion rate or incipient diabetic nephropathy (median -36 to -43%), but significantly reduced in patients with clinical diabetic nephropathy (median 0%; P less than 0.005), nine of whom had elevated beta 2-M excretion rates, suggesting tubular dysfunction. Except for beta 2-M excretion rate in patients with clinical diabetic nephropathy, the diurnal variations in albumin excretion rate, IgG excretion rate and beta 2-M excretion rate were larger than the diurnal variation in creatinine excretion rate (median -7 to -11%, P less than 0.005). Diurnal variations in albumin excretion rate and IgG excretion rate were highly correlated (r = 0.89, P less than 0.00001). These data suggest that similar mechanisms may account for diurnal variations in albumin excretion rate and IgG excretion rate.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0931-0509 UR - https://www.unboundmedicine.com/medline/citation/1881577/Diurnal_variation_in_urinary_protein_excretion_in_diabetic_nephropathy_ DB - PRIME DP - Unbound Medicine ER -