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The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus.
Basic Clin Pharmacol Toxicol 2008; 103(2):150-6BC

Abstract

The effect of cannabinoids on motion-induced emesis is unknown. The present study investigated the action of phytocannabinoids against motion-induced emesis in Suncus murinus. Suncus murinus were injected intraperitoneally with either cannabidiol (CBD) (0.5, 1, 2, 5, 10, 20 and 40 mg/kg), Delta(9)-tetrahydrocannabinol (Delta(9)-THC; 0.5, 3, 5 and 10 mg/kg) or vehicle 45 min. before exposure to a 10-min. horizontal motion stimulus (amplitude 40 mm, frequency 1 Hz). In further investigations, the CB(1) receptor antagonist, N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM 251; 5 mg/kg), was injected 15 min. prior to an injection of Delta(9)-THC (3 mg/kg). The motion stimulus was applied 45 min. later. The number of emetic episodes and latency of onset to the first emetic episode were recorded. Pre-treatment with the above doses of CBD did not modify the emetic response to the motion stimulus as compared to the vehicle-treated controls. Application of the higher doses of Delta(9)-THC induced emesis in its own right, which was inhibited by AM 251. Furthermore, pre-treatment with Delta(9)-THC dose-dependently attenuated motion-induced emesis, an effect that was inhibited by AM 251. AM 251 neither induced an emetic response nor modified motion-induced emesis. The present study indicates that Delta(9)-THC, acting via the CB(1) receptors, is anti-emetic to motion, and that CBD has no effect on motion-induced emesis in Suncus murinus.

Authors+Show Affiliations

The School of Pharmacy, University of Bradford, Bradford, West Yorkshire, UK. ncluny@ucalgary.caNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18816298

Citation

Cluny, Nina L., et al. "The Effects of Cannabidiol and Tetrahydrocannabinol On Motion-induced Emesis in Suncus Murinus." Basic & Clinical Pharmacology & Toxicology, vol. 103, no. 2, 2008, pp. 150-6.
Cluny NL, Naylor RJ, Whittle BA, et al. The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus. Basic Clin Pharmacol Toxicol. 2008;103(2):150-6.
Cluny, N. L., Naylor, R. J., Whittle, B. A., & Javid, F. A. (2008). The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus. Basic & Clinical Pharmacology & Toxicology, 103(2), pp. 150-6. doi:10.1111/j.1742-7843.2008.00253.x.
Cluny NL, et al. The Effects of Cannabidiol and Tetrahydrocannabinol On Motion-induced Emesis in Suncus Murinus. Basic Clin Pharmacol Toxicol. 2008;103(2):150-6. PubMed PMID: 18816298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus. AU - Cluny,Nina L, AU - Naylor,Robert J, AU - Whittle,Brian A, AU - Javid,Farideh A, PY - 2008/9/26/pubmed PY - 2008/11/13/medline PY - 2008/9/26/entrez SP - 150 EP - 6 JF - Basic & clinical pharmacology & toxicology JO - Basic Clin. Pharmacol. Toxicol. VL - 103 IS - 2 N2 - The effect of cannabinoids on motion-induced emesis is unknown. The present study investigated the action of phytocannabinoids against motion-induced emesis in Suncus murinus. Suncus murinus were injected intraperitoneally with either cannabidiol (CBD) (0.5, 1, 2, 5, 10, 20 and 40 mg/kg), Delta(9)-tetrahydrocannabinol (Delta(9)-THC; 0.5, 3, 5 and 10 mg/kg) or vehicle 45 min. before exposure to a 10-min. horizontal motion stimulus (amplitude 40 mm, frequency 1 Hz). In further investigations, the CB(1) receptor antagonist, N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM 251; 5 mg/kg), was injected 15 min. prior to an injection of Delta(9)-THC (3 mg/kg). The motion stimulus was applied 45 min. later. The number of emetic episodes and latency of onset to the first emetic episode were recorded. Pre-treatment with the above doses of CBD did not modify the emetic response to the motion stimulus as compared to the vehicle-treated controls. Application of the higher doses of Delta(9)-THC induced emesis in its own right, which was inhibited by AM 251. Furthermore, pre-treatment with Delta(9)-THC dose-dependently attenuated motion-induced emesis, an effect that was inhibited by AM 251. AM 251 neither induced an emetic response nor modified motion-induced emesis. The present study indicates that Delta(9)-THC, acting via the CB(1) receptors, is anti-emetic to motion, and that CBD has no effect on motion-induced emesis in Suncus murinus. SN - 1742-7843 UR - https://www.unboundmedicine.com/medline/citation/18816298/The_effects_of_cannabidiol_and_tetrahydrocannabinol_on_motion_induced_emesis_in_Suncus_murinus_ L2 - https://doi.org/10.1111/j.1742-7843.2008.00253.x DB - PRIME DP - Unbound Medicine ER -