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Amelioration of cyclosporine A-induced renal, hepatic and cardiac damages by ellagic acid in rats.
Basic Clin Pharmacol Toxicol. 2008 Aug; 103(2):186-91.BC

Abstract

Treatment with cyclosporine A has significantly improved long-term survival after organ transplantations. Cyclosporine A also causes a dose-related decrease in body functions in experimental animals and human beings. The generation of reactive oxygen species has been implicated in cyclosporine A-induced dysfunctions. The aim of this study was to determine the effects of ellagic acid on cyclosporine A-induced alterations in the kidney, liver and heart oxidant/antioxidant system. The control group was treated with placebo and subcutaneous injection of 0.5 ml isotonic saline + 0.5 ml slightly alkaline solution for 21 days. The cyclosporine A group received a subcutaneous injection of cyclosporine A (15 mg/kg) + 0.5 ml slightly alkaline solution for 21 days. The ellagic acid group was treated with a subcutaneous injection of 0.5 ml isotonic saline + ellagic acid (10 mg/kg) for 21 days. The cyclosporine A plus ellagic acid group received a subcutaneous injection of cyclosporine A + ellagic acid for 21 days. Ellagic acid and slightly alkaline solution were administered by gavage. The rats were killed at the end of the treatment period. Malondialdehyde (MDA) and reduced glutathione (GSH) levels, glutathione peroxidase (GSH-Px) and catalase (CAT) activities were determined in kidney, liver and heart tissues. While administration of cyclosporine A increased the MDA levels in kidney, liver and heart tissues, it decreased the GSH, GSH-Px and CAT in these samples when compared to the control group. However, the simultaneously administration of ellagic acid markedly normalized the cyclosporine A-induced liver and heart MDA levels, liver CAT activities and GSH-Px activities of all samples. Cyclosporine A caused marked damages in the histopathological status of kidney, liver and heart tissues, which were partially ameliorated by ellagic acid administration. In conclusion, ellagic acid may be used in combination with cyclosporine A in transplantation treatment to improve the cyclosporine A-induced oxidative stress parameters and other adverse effects.

Authors+Show Affiliations

Department of Physiology, Facult of Veterinary Medicine, Firat University, Elazig, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18816304

Citation

Yüce, Abdurrauf, et al. "Amelioration of Cyclosporine A-induced Renal, Hepatic and Cardiac Damages By Ellagic Acid in Rats." Basic & Clinical Pharmacology & Toxicology, vol. 103, no. 2, 2008, pp. 186-91.
Yüce A, Ateşşahin A, Ceribaşi AO. Amelioration of cyclosporine A-induced renal, hepatic and cardiac damages by ellagic acid in rats. Basic Clin Pharmacol Toxicol. 2008;103(2):186-91.
Yüce, A., Ateşşahin, A., & Ceribaşi, A. O. (2008). Amelioration of cyclosporine A-induced renal, hepatic and cardiac damages by ellagic acid in rats. Basic & Clinical Pharmacology & Toxicology, 103(2), 186-91. https://doi.org/10.1111/j.1742-7843.2008.00284.x
Yüce A, Ateşşahin A, Ceribaşi AO. Amelioration of Cyclosporine A-induced Renal, Hepatic and Cardiac Damages By Ellagic Acid in Rats. Basic Clin Pharmacol Toxicol. 2008;103(2):186-91. PubMed PMID: 18816304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amelioration of cyclosporine A-induced renal, hepatic and cardiac damages by ellagic acid in rats. AU - Yüce,Abdurrauf, AU - Ateşşahin,Ahmet, AU - Ceribaşi,Ali Osman, PY - 2008/9/26/pubmed PY - 2008/11/13/medline PY - 2008/9/26/entrez SP - 186 EP - 91 JF - Basic & clinical pharmacology & toxicology JO - Basic Clin Pharmacol Toxicol VL - 103 IS - 2 N2 - Treatment with cyclosporine A has significantly improved long-term survival after organ transplantations. Cyclosporine A also causes a dose-related decrease in body functions in experimental animals and human beings. The generation of reactive oxygen species has been implicated in cyclosporine A-induced dysfunctions. The aim of this study was to determine the effects of ellagic acid on cyclosporine A-induced alterations in the kidney, liver and heart oxidant/antioxidant system. The control group was treated with placebo and subcutaneous injection of 0.5 ml isotonic saline + 0.5 ml slightly alkaline solution for 21 days. The cyclosporine A group received a subcutaneous injection of cyclosporine A (15 mg/kg) + 0.5 ml slightly alkaline solution for 21 days. The ellagic acid group was treated with a subcutaneous injection of 0.5 ml isotonic saline + ellagic acid (10 mg/kg) for 21 days. The cyclosporine A plus ellagic acid group received a subcutaneous injection of cyclosporine A + ellagic acid for 21 days. Ellagic acid and slightly alkaline solution were administered by gavage. The rats were killed at the end of the treatment period. Malondialdehyde (MDA) and reduced glutathione (GSH) levels, glutathione peroxidase (GSH-Px) and catalase (CAT) activities were determined in kidney, liver and heart tissues. While administration of cyclosporine A increased the MDA levels in kidney, liver and heart tissues, it decreased the GSH, GSH-Px and CAT in these samples when compared to the control group. However, the simultaneously administration of ellagic acid markedly normalized the cyclosporine A-induced liver and heart MDA levels, liver CAT activities and GSH-Px activities of all samples. Cyclosporine A caused marked damages in the histopathological status of kidney, liver and heart tissues, which were partially ameliorated by ellagic acid administration. In conclusion, ellagic acid may be used in combination with cyclosporine A in transplantation treatment to improve the cyclosporine A-induced oxidative stress parameters and other adverse effects. SN - 1742-7843 UR - https://www.unboundmedicine.com/medline/citation/18816304/Amelioration_of_cyclosporine_A_induced_renal_hepatic_and_cardiac_damages_by_ellagic_acid_in_rats_ L2 - https://doi.org/10.1111/j.1742-7843.2008.00284.x DB - PRIME DP - Unbound Medicine ER -