Tags

Type your tag names separated by a space and hit enter

Effects of onion on serum uric acid levels and hepatic xanthine dehydrogenase/xanthine oxidase activities in hyperuricemic rats.
Pak J Biol Sci. 2008 Jul 15; 11(14):1779-84.PJ

Abstract

The aim of this study was to investigate the effects of onion on serum uric acid levels and hepatic Xanthine Dehydrogenase/Xanthine Oxidase activities in normal and hyperuricemic rats. Hyperuricemia was induced by intraperitoneal injection of 250 mg kg(-1) potassium oxonate in rats. Oral administration of onion at 3.5 and 7.0 mg kg(-1) day(-1) for 7 days was able to reduce serum uric acid levels in hyperuricemic rats with no significant effects on the level of this compound in the normal animals. In addition, onion when tested in vivo on rat liver homogeneities elicited significant inhibitory actions on the Xanthine Dehydrogenase (XDH) and Xanthine Oxidase (XO) activities. This effect resulted less potent than that of allopurinol. However, the hypouricemic effect observed in the experimental animal did not seem to parallel the change in XDH and XO activities, implying that the onion might be acting via other mechanisms apart from simple inhibition of enzyme activities. Such hypouricemic action and enzyme inhibitory activity of onion makes it a possible alternative for allopurinol, or at least in combination therapy to minimize the side-effects of allopurinol, in particular in long-term application.

Authors+Show Affiliations

School of Health, Tehran University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18817216

Citation

Haidari, Fatemeh, et al. "Effects of Onion On Serum Uric Acid Levels and Hepatic Xanthine Dehydrogenase/xanthine Oxidase Activities in Hyperuricemic Rats." Pakistan Journal of Biological Sciences : PJBS, vol. 11, no. 14, 2008, pp. 1779-84.
Haidari F, Rashidi MR, Keshavarz SA, et al. Effects of onion on serum uric acid levels and hepatic xanthine dehydrogenase/xanthine oxidase activities in hyperuricemic rats. Pak J Biol Sci. 2008;11(14):1779-84.
Haidari, F., Rashidi, M. R., Keshavarz, S. A., Mahboob, S. A., Eshraghian, M. R., & Shahi, M. M. (2008). Effects of onion on serum uric acid levels and hepatic xanthine dehydrogenase/xanthine oxidase activities in hyperuricemic rats. Pakistan Journal of Biological Sciences : PJBS, 11(14), 1779-84.
Haidari F, et al. Effects of Onion On Serum Uric Acid Levels and Hepatic Xanthine Dehydrogenase/xanthine Oxidase Activities in Hyperuricemic Rats. Pak J Biol Sci. 2008 Jul 15;11(14):1779-84. PubMed PMID: 18817216.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of onion on serum uric acid levels and hepatic xanthine dehydrogenase/xanthine oxidase activities in hyperuricemic rats. AU - Haidari,Fatemeh, AU - Rashidi,Mohammad Reza, AU - Keshavarz,Seid Ali, AU - Mahboob,Soltan Ali, AU - Eshraghian,Mohammad Reza, AU - Shahi,Majid Mohamad, PY - 2008/9/27/pubmed PY - 2008/10/17/medline PY - 2008/9/27/entrez SP - 1779 EP - 84 JF - Pakistan journal of biological sciences : PJBS JO - Pak. J. Biol. Sci. VL - 11 IS - 14 N2 - The aim of this study was to investigate the effects of onion on serum uric acid levels and hepatic Xanthine Dehydrogenase/Xanthine Oxidase activities in normal and hyperuricemic rats. Hyperuricemia was induced by intraperitoneal injection of 250 mg kg(-1) potassium oxonate in rats. Oral administration of onion at 3.5 and 7.0 mg kg(-1) day(-1) for 7 days was able to reduce serum uric acid levels in hyperuricemic rats with no significant effects on the level of this compound in the normal animals. In addition, onion when tested in vivo on rat liver homogeneities elicited significant inhibitory actions on the Xanthine Dehydrogenase (XDH) and Xanthine Oxidase (XO) activities. This effect resulted less potent than that of allopurinol. However, the hypouricemic effect observed in the experimental animal did not seem to parallel the change in XDH and XO activities, implying that the onion might be acting via other mechanisms apart from simple inhibition of enzyme activities. Such hypouricemic action and enzyme inhibitory activity of onion makes it a possible alternative for allopurinol, or at least in combination therapy to minimize the side-effects of allopurinol, in particular in long-term application. SN - 1028-8880 UR - https://www.unboundmedicine.com/medline/citation/18817216/Effects_of_onion_on_serum_uric_acid_levels_and_hepatic_xanthine_dehydrogenase/xanthine_oxidase_activities_in_hyperuricemic_rats_ DB - PRIME DP - Unbound Medicine ER -