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Glutaraldehyde cross-linked chitosan microspheres for controlled delivery of zidovudine.
J Microencapsul. 2009 May; 26(3):214-22.JM

Abstract

Zidovudine-Chitosan microspheres were prepared by a suspension cross-linking method. The chitosan was dissolved in 2% acetic acid solution and this solution was dispersed in the light liquid paraffin. Span-80 was used as an emulsifier and glutaraldehyde as cross-linking agent. The prepared microspheres were slight yellow, free flowing and characterized by drug loading, infrared spectroscopy (IR), differential scanning colorimetry (DSC) and scanning electron microscopy (SEM). The in-vitro release studies are performed in pH 7.4 buffer solution. Microspheres produced are spherical and have smooth surfaces, with sizes ranging between 60-210 µm, as evidenced by SEM and particle size analysis. The drug loaded microspheres showed up to 60% of entrapment and release was extended up to 18-24 h. Among all the systems studied, the 35% Glutaraldehyde crosslinked, microspheres with 1 : 6 drug/chitosan ratio showed 75% release at 12 h. The infrared spectra and DSC thermograms showed stable character of zidovudine in the drug loaded microspheres and revealed the absence of drug-polymer interactions. Data obtained from in vitro release were fitted to various kinetic models and high correlation was obtained in the Higuchi model. The drug release was found to be diffusion controlled.

Authors+Show Affiliations

Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576104, India. ushaynayak@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18819029

Citation

Nayak, Usha Yogendra, et al. "Glutaraldehyde Cross-linked Chitosan Microspheres for Controlled Delivery of Zidovudine." Journal of Microencapsulation, vol. 26, no. 3, 2009, pp. 214-22.
Nayak UY, Gopal S, Mutalik S, et al. Glutaraldehyde cross-linked chitosan microspheres for controlled delivery of zidovudine. J Microencapsul. 2009;26(3):214-22.
Nayak, U. Y., Gopal, S., Mutalik, S., Ranjith, A. K., Reddy, M. S., Gupta, P., & Udupa, N. (2009). Glutaraldehyde cross-linked chitosan microspheres for controlled delivery of zidovudine. Journal of Microencapsulation, 26(3), 214-22. https://doi.org/10.1080/02652040802246325
Nayak UY, et al. Glutaraldehyde Cross-linked Chitosan Microspheres for Controlled Delivery of Zidovudine. J Microencapsul. 2009;26(3):214-22. PubMed PMID: 18819029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glutaraldehyde cross-linked chitosan microspheres for controlled delivery of zidovudine. AU - Nayak,Usha Yogendra, AU - Gopal,Shavi, AU - Mutalik,Srinivas, AU - Ranjith,Averinen Kumar, AU - Reddy,Meka Sreenivasa, AU - Gupta,Purushotham, AU - Udupa,Nayanabhirama, PY - 2008/9/27/pubmed PY - 2011/5/25/medline PY - 2008/9/27/entrez SP - 214 EP - 22 JF - Journal of microencapsulation JO - J Microencapsul VL - 26 IS - 3 N2 - Zidovudine-Chitosan microspheres were prepared by a suspension cross-linking method. The chitosan was dissolved in 2% acetic acid solution and this solution was dispersed in the light liquid paraffin. Span-80 was used as an emulsifier and glutaraldehyde as cross-linking agent. The prepared microspheres were slight yellow, free flowing and characterized by drug loading, infrared spectroscopy (IR), differential scanning colorimetry (DSC) and scanning electron microscopy (SEM). The in-vitro release studies are performed in pH 7.4 buffer solution. Microspheres produced are spherical and have smooth surfaces, with sizes ranging between 60-210 µm, as evidenced by SEM and particle size analysis. The drug loaded microspheres showed up to 60% of entrapment and release was extended up to 18-24 h. Among all the systems studied, the 35% Glutaraldehyde crosslinked, microspheres with 1 : 6 drug/chitosan ratio showed 75% release at 12 h. The infrared spectra and DSC thermograms showed stable character of zidovudine in the drug loaded microspheres and revealed the absence of drug-polymer interactions. Data obtained from in vitro release were fitted to various kinetic models and high correlation was obtained in the Higuchi model. The drug release was found to be diffusion controlled. SN - 1464-5246 UR - https://www.unboundmedicine.com/medline/citation/18819029/Glutaraldehyde_cross_linked_chitosan_microspheres_for_controlled_delivery_of_zidovudine_ L2 - http://www.tandfonline.com/doi/full/10.1080/02652040802246325 DB - PRIME DP - Unbound Medicine ER -