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Effect of guava (Psidium guajava Linn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats.
Phytother Res. 2008 Nov; 22(11):1458-64.PR

Abstract

This study investigated the effect of aqueous and ethanol soluble solid extracts of guava (Psidium guajava Linn.) leaves on hypoglycemia and glucose metabolism in type 2 diabetic rats. Low-dose streptozotocin (STZ) and nicotinamide were injected into Sprague-Dawley (SD) rats to induce type 2 diabetes. Acute and long-term feeding tests were carried out, and an oral glucose tolerance test (OGTT) to follow the changes in plasma glucose and insulin levels was performed to evaluate the antihyperglycemic effect of guava leaf extracts in diabetic rats.The results of acute and long-term feeding tests showed a significant reduction in the blood sugar level in diabetic rats fed with either the aqueous or ethanol extract of guava leaves (p < 0.05). Long-term administration of guava leaf extracts increased the plasma insulin level and glucose utilization in diabetic rats. The results also indicated that the activities of hepatic hexokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase in diabetic rats fed with aqueous extracts were higher than in the normal diabetic group (p < 0.05). On the other hand, diabetic rats treated with the ethanol extract raised the activities of hepatic hexokinase and glucose-6-phosphate dehydrogenase (p < 0.05) only. The experiments provided evidence to support the antihyperglycemic effect of guava leaf extract and the health function of guava leaves against type 2 diabetes.

Authors+Show Affiliations

Department of Medical Nutrition, I-Shou University, No.1, Sec. 1, Syuecheng Road, Dashu Township, Kaohsiung County 84001, Taiwan. scs@isu.edu.twNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18819164

Citation

Shen, Szu-Chuan, et al. "Effect of Guava (Psidium Guajava Linn.) Leaf Soluble Solids On Glucose Metabolism in Type 2 Diabetic Rats." Phytotherapy Research : PTR, vol. 22, no. 11, 2008, pp. 1458-64.
Shen SC, Cheng FC, Wu NJ. Effect of guava (Psidium guajava Linn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats. Phytother Res. 2008;22(11):1458-64.
Shen, S. C., Cheng, F. C., & Wu, N. J. (2008). Effect of guava (Psidium guajava Linn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats. Phytotherapy Research : PTR, 22(11), 1458-64. https://doi.org/10.1002/ptr.2476
Shen SC, Cheng FC, Wu NJ. Effect of Guava (Psidium Guajava Linn.) Leaf Soluble Solids On Glucose Metabolism in Type 2 Diabetic Rats. Phytother Res. 2008;22(11):1458-64. PubMed PMID: 18819164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of guava (Psidium guajava Linn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats. AU - Shen,Szu-Chuan, AU - Cheng,Fang-Chi, AU - Wu,Ning-Jung, PY - 2008/9/27/pubmed PY - 2008/12/17/medline PY - 2008/9/27/entrez SP - 1458 EP - 64 JF - Phytotherapy research : PTR JO - Phytother Res VL - 22 IS - 11 N2 - This study investigated the effect of aqueous and ethanol soluble solid extracts of guava (Psidium guajava Linn.) leaves on hypoglycemia and glucose metabolism in type 2 diabetic rats. Low-dose streptozotocin (STZ) and nicotinamide were injected into Sprague-Dawley (SD) rats to induce type 2 diabetes. Acute and long-term feeding tests were carried out, and an oral glucose tolerance test (OGTT) to follow the changes in plasma glucose and insulin levels was performed to evaluate the antihyperglycemic effect of guava leaf extracts in diabetic rats.The results of acute and long-term feeding tests showed a significant reduction in the blood sugar level in diabetic rats fed with either the aqueous or ethanol extract of guava leaves (p < 0.05). Long-term administration of guava leaf extracts increased the plasma insulin level and glucose utilization in diabetic rats. The results also indicated that the activities of hepatic hexokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase in diabetic rats fed with aqueous extracts were higher than in the normal diabetic group (p < 0.05). On the other hand, diabetic rats treated with the ethanol extract raised the activities of hepatic hexokinase and glucose-6-phosphate dehydrogenase (p < 0.05) only. The experiments provided evidence to support the antihyperglycemic effect of guava leaf extract and the health function of guava leaves against type 2 diabetes. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/18819164/Effect_of_guava__Psidium_guajava_Linn___leaf_soluble_solids_on_glucose_metabolism_in_type_2_diabetic_rats_ DB - PRIME DP - Unbound Medicine ER -