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[Alzheimer's disease: cellular and molecular aspects].
Bull Acad Natl Med. 2008 Feb; 192(2):323-31; discussion 331-2.BA

Abstract

Alzheimer's disease is characterized by the presence of neurofibrillary tangles and senile plaque in the brain. Both disorders must be present in order to confirm a clinical diagnosis of Alzheimer's disease. Neurofibrillary tangles contain hyperphosphorylated microtubule-associated protein tau, while senile plaque contains a core of amyloidpeptide derived from its precursor. Phosphorylation of both amyloid precursor protein and tau represents a biochemical link between the two characteristic lesions of Alzheimer's disease.

Authors+Show Affiliations

Octave JN
Laboratoire de Pharmacologie Expérimentale, Université catholique de Louvain, FARL 5410, Avenue Hippocrate 54 B-1200 Bruxelles.
Pierrot N
No affiliation info available

MeSH

Alzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorCalcium SignalingCyclin-Dependent Kinase 5Glycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHumansNeurofibrillary TanglesNeuronsPhosphorylationPlaque, AmyloidProtein Processing, Post-TranslationalProtein Structure, Tertiarytau Proteins

Pub Type(s)

Journal Article
Review

Language

fre

PubMed ID

18819686

Citation

Octave, Jean-Noël, and Nathalie Pierrot. "[Alzheimer's Disease: Cellular and Molecular Aspects]." Bulletin De l'Academie Nationale De Medecine, vol. 192, no. 2, 2008, pp. 323-31; discussion 331-2.
Octave JN, Pierrot N. [Alzheimer's disease: cellular and molecular aspects]. Bull Acad Natl Med. 2008;192(2):323-31; discussion 331-2.
Octave, J. N., & Pierrot, N. (2008). [Alzheimer's disease: cellular and molecular aspects]. Bulletin De l'Academie Nationale De Medecine, 192(2), 323-31; discussion 331-2.
Octave JN, Pierrot N. [Alzheimer's Disease: Cellular and Molecular Aspects]. Bull Acad Natl Med. 2008;192(2):323-31; discussion 331-2. PubMed PMID: 18819686.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Alzheimer's disease: cellular and molecular aspects]. AU - Octave,Jean-Noël, AU - Pierrot,Nathalie, PY - 2008/9/30/pubmed PY - 2008/11/15/medline PY - 2008/9/30/entrez SP - 323-31; discussion 331-2 JF - Bulletin de l'Academie nationale de medecine JO - Bull Acad Natl Med VL - 192 IS - 2 N2 - Alzheimer's disease is characterized by the presence of neurofibrillary tangles and senile plaque in the brain. Both disorders must be present in order to confirm a clinical diagnosis of Alzheimer's disease. Neurofibrillary tangles contain hyperphosphorylated microtubule-associated protein tau, while senile plaque contains a core of amyloidpeptide derived from its precursor. Phosphorylation of both amyloid precursor protein and tau represents a biochemical link between the two characteristic lesions of Alzheimer's disease. SN - 0001-4079 UR - https://www.unboundmedicine.com/medline/citation/18819686/[Alzheimer's_disease:_cellular_and_molecular_aspects]_ DB - PRIME DP - Unbound Medicine ER -