[Alzheimer's disease: cellular and molecular aspects].
Alzheimer's disease is characterized by the presence of neurofibrillary tangles and senile plaque in the brain. Both disorders must be present in order to confirm a clinical diagnosis of Alzheimer's disease. Neurofibrillary tangles contain hyperphosphorylated microtubule-associated protein tau, while senile plaque contains a core of amyloidpeptide derived from its precursor. Phosphorylation of both amyloid precursor protein and tau represents a biochemical link between the two characteristic lesions of Alzheimer's disease.
Laboratoire de Pharmacologie Expérimentale, Université catholique de Louvain, FARL 5410, Avenue Hippocrate 54 B-1200 Bruxelles.
Amyloid beta-Protein Precursor
Cyclin-Dependent Kinase 5
Glycogen Synthase Kinase 3
Glycogen Synthase Kinase 3 beta
Protein Processing, Post-Translational
Protein Structure, Tertiary
Pub Type(s)Journal Article