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[Alzheimer's disease: cellular and molecular aspects].

Abstract

Alzheimer's disease is characterized by the presence of neurofibrillary tangles and senile plaque in the brain. Both disorders must be present in order to confirm a clinical diagnosis of Alzheimer's disease. Neurofibrillary tangles contain hyperphosphorylated microtubule-associated protein tau, while senile plaque contains a core of amyloidpeptide derived from its precursor. Phosphorylation of both amyloid precursor protein and tau represents a biochemical link between the two characteristic lesions of Alzheimer's disease.

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  • Authors+Show Affiliations

    ,

    Laboratoire de Pharmacologie Expérimentale, Université catholique de Louvain, FARL 5410, Avenue Hippocrate 54 B-1200 Bruxelles.

    Source

    Bulletin de l'Academie nationale de medecine 192:2 2008 Feb pg 323-31; discussion 331-2

    MeSH

    Alzheimer Disease
    Amyloid beta-Peptides
    Amyloid beta-Protein Precursor
    Calcium Signaling
    Cyclin-Dependent Kinase 5
    Glycogen Synthase Kinase 3
    Glycogen Synthase Kinase 3 beta
    Humans
    Neurofibrillary Tangles
    Neurons
    Phosphorylation
    Plaque, Amyloid
    Protein Processing, Post-Translational
    Protein Structure, Tertiary
    tau Proteins

    Pub Type(s)

    Journal Article
    Review

    Language

    fre

    PubMed ID

    18819686

    Citation

    Octave, Jean-Noël, and Nathalie Pierrot. "[Alzheimer's Disease: Cellular and Molecular Aspects]." Bulletin De l'Academie Nationale De Medecine, vol. 192, no. 2, 2008, pp. 323-31; discussion 331-2.
    Octave JN, Pierrot N. [Alzheimer's disease: cellular and molecular aspects]. Bull Acad Natl Med. 2008;192(2):323-31; discussion 331-2.
    Octave, J. N., & Pierrot, N. (2008). [Alzheimer's disease: cellular and molecular aspects]. Bulletin De l'Academie Nationale De Medecine, 192(2), pp. 323-31; discussion 331-2.
    Octave JN, Pierrot N. [Alzheimer's Disease: Cellular and Molecular Aspects]. Bull Acad Natl Med. 2008;192(2):323-31; discussion 331-2. PubMed PMID: 18819686.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - [Alzheimer's disease: cellular and molecular aspects]. AU - Octave,Jean-Noël, AU - Pierrot,Nathalie, PY - 2008/9/30/pubmed PY - 2008/11/15/medline PY - 2008/9/30/entrez SP - 323-31; discussion 331-2 JF - Bulletin de l'Academie nationale de medecine JO - Bull. Acad. Natl. Med. VL - 192 IS - 2 N2 - Alzheimer's disease is characterized by the presence of neurofibrillary tangles and senile plaque in the brain. Both disorders must be present in order to confirm a clinical diagnosis of Alzheimer's disease. Neurofibrillary tangles contain hyperphosphorylated microtubule-associated protein tau, while senile plaque contains a core of amyloidpeptide derived from its precursor. Phosphorylation of both amyloid precursor protein and tau represents a biochemical link between the two characteristic lesions of Alzheimer's disease. SN - 0001-4079 UR - https://www.unboundmedicine.com/medline/citation/18819686/[Alzheimer's_disease:_cellular_and_molecular_aspects]_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -