[Alzheimer's disease: cellular and molecular aspects].Bull Acad Natl Med. 2008 Feb; 192(2):323-31; discussion 331-2.BA
Abstract
Alzheimer's disease is characterized by the presence of neurofibrillary tangles and senile plaque in the brain. Both disorders must be present in order to confirm a clinical diagnosis of Alzheimer's disease. Neurofibrillary tangles contain hyperphosphorylated microtubule-associated protein tau, while senile plaque contains a core of amyloidpeptide derived from its precursor. Phosphorylation of both amyloid precursor protein and tau represents a biochemical link between the two characteristic lesions of Alzheimer's disease.
MeSH
Alzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorCalcium SignalingCyclin-Dependent Kinase 5Glycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHumansNeurofibrillary TanglesNeuronsPhosphorylationPlaque, AmyloidProtein Processing, Post-TranslationalProtein Structure, Tertiarytau Proteins
Pub Type(s)
Journal Article
Review
Language
fre
PubMed ID
18819686
Citation
Octave, Jean-Noël, and Nathalie Pierrot. "[Alzheimer's Disease: Cellular and Molecular Aspects]." Bulletin De l'Academie Nationale De Medecine, vol. 192, no. 2, 2008, pp. 323-31; discussion 331-2.
Octave JN, Pierrot N. [Alzheimer's disease: cellular and molecular aspects]. Bull Acad Natl Med. 2008;192(2):323-31; discussion 331-2.
Octave, J. N., & Pierrot, N. (2008). [Alzheimer's disease: cellular and molecular aspects]. Bulletin De l'Academie Nationale De Medecine, 192(2), 323-31; discussion 331-2.
Octave JN, Pierrot N. [Alzheimer's Disease: Cellular and Molecular Aspects]. Bull Acad Natl Med. 2008;192(2):323-31; discussion 331-2. PubMed PMID: 18819686.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - [Alzheimer's disease: cellular and molecular aspects].
AU - Octave,Jean-Noël,
AU - Pierrot,Nathalie,
PY - 2008/9/30/pubmed
PY - 2008/11/15/medline
PY - 2008/9/30/entrez
SP - 323-31; discussion 331-2
JF - Bulletin de l'Academie nationale de medecine
JO - Bull Acad Natl Med
VL - 192
IS - 2
N2 - Alzheimer's disease is characterized by the presence of neurofibrillary tangles and senile plaque in the brain. Both disorders must be present in order to confirm a clinical diagnosis of Alzheimer's disease. Neurofibrillary tangles contain hyperphosphorylated microtubule-associated protein tau, while senile plaque contains a core of amyloidpeptide derived from its precursor. Phosphorylation of both amyloid precursor protein and tau represents a biochemical link between the two characteristic lesions of Alzheimer's disease.
SN - 0001-4079
UR - https://www.unboundmedicine.com/medline/citation/18819686/[Alzheimer's_disease:_cellular_and_molecular_aspects]_
DB - PRIME
DP - Unbound Medicine
ER -