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Differences in traditional and emerging cardiovascular risk factors of subjects discordantly classified by metabolic syndrome definitions of the International Diabetes Federation and the National Cholesterol Education Program.
Nutr Metab Cardiovasc Dis. 2009 Jul; 19(6):417-22.NM

Abstract

BACKGROUND AND AIM

Several working definitions of metabolic syndrome have been proposed for clinical use. However, individuals can be discordantly classified as having or not having metabolic syndrome depending on the choice of one or another definition. This study compared the cardiovascular risk profile of subjects concordantly and discordantly diagnosed by the criteria of the National Cholesterol Education Program (NCEP) and the criteria of the International Diabetes Federation (IDF).

METHODS AND RESULTS

Nine hundred and twenty-nine non-diabetic adult subjects belonging to a cross-sectional population-based study in Gran Canaria island (Spain) were assessed. Participants completed a questionnaire and underwent physical examination, fasting blood analyses, and a standardized oral glucose tolerance test. Two hundred and four subjects (22%) had metabolic syndrome according to both definitions, 31 (3.3%) only by the IDF criteria, and 5 (0.5%) only by the NCEP criteria. Participants fulfilling both proposals showed more adverse age and sex-adjusted measures of BMI, waist, HDL cholesterol, triglycerides, post-load glucose, HOMA-IR and plasminogen inhibitor activator-1 (PAI-1) than individuals exclusively satisfying the IDF criteria. Moreover, in contrast to subjects meeting both criteria, those that fulfilled only the IDF criteria had levels of BMI, waist, total and HDL cholesterol, post-load glucose, glycated HbA1c, C-reactive protein, PAI-1 and fibrinogen not significantly different from those observed in subjects without metabolic syndrome.

CONCLUSION

The IDF definition identifies a surplus of individuals whose cardiovascular risk profile, particularly regarding to some non-traditional cardiovascular risk factors, is less adverse than that observed in subjects also diagnosed by the NCEP definition.

Authors+Show Affiliations

Section of Endocrinology and Nutrition, Hospital Universitario Insular, Avda. Marítima del Sur s/n, 35016 Las Palmas de Gran Canaria, Spain. mborcor@yahoo.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18819785

Citation

Boronat, M, et al. "Differences in Traditional and Emerging Cardiovascular Risk Factors of Subjects Discordantly Classified By Metabolic Syndrome Definitions of the International Diabetes Federation and the National Cholesterol Education Program." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 19, no. 6, 2009, pp. 417-22.
Boronat M, Saavedra P, Varillas VF, et al. Differences in traditional and emerging cardiovascular risk factors of subjects discordantly classified by metabolic syndrome definitions of the International Diabetes Federation and the National Cholesterol Education Program. Nutr Metab Cardiovasc Dis. 2009;19(6):417-22.
Boronat, M., Saavedra, P., Varillas, V. F., Wagner, A. M., López-Plasencia, Y., Alberiche, M. P., & Nóvoa, F. J. (2009). Differences in traditional and emerging cardiovascular risk factors of subjects discordantly classified by metabolic syndrome definitions of the International Diabetes Federation and the National Cholesterol Education Program. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 19(6), 417-22. https://doi.org/10.1016/j.numecd.2008.07.010
Boronat M, et al. Differences in Traditional and Emerging Cardiovascular Risk Factors of Subjects Discordantly Classified By Metabolic Syndrome Definitions of the International Diabetes Federation and the National Cholesterol Education Program. Nutr Metab Cardiovasc Dis. 2009;19(6):417-22. PubMed PMID: 18819785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in traditional and emerging cardiovascular risk factors of subjects discordantly classified by metabolic syndrome definitions of the International Diabetes Federation and the National Cholesterol Education Program. AU - Boronat,M, AU - Saavedra,P, AU - Varillas,V F, AU - Wagner,A M, AU - López-Plasencia,Y, AU - Alberiche,M P, AU - Nóvoa,F J, Y1 - 2008/09/25/ PY - 2008/04/22/received PY - 2008/07/15/revised PY - 2008/07/18/accepted PY - 2008/9/30/pubmed PY - 2009/9/9/medline PY - 2008/9/30/entrez SP - 417 EP - 22 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 19 IS - 6 N2 - BACKGROUND AND AIM: Several working definitions of metabolic syndrome have been proposed for clinical use. However, individuals can be discordantly classified as having or not having metabolic syndrome depending on the choice of one or another definition. This study compared the cardiovascular risk profile of subjects concordantly and discordantly diagnosed by the criteria of the National Cholesterol Education Program (NCEP) and the criteria of the International Diabetes Federation (IDF). METHODS AND RESULTS: Nine hundred and twenty-nine non-diabetic adult subjects belonging to a cross-sectional population-based study in Gran Canaria island (Spain) were assessed. Participants completed a questionnaire and underwent physical examination, fasting blood analyses, and a standardized oral glucose tolerance test. Two hundred and four subjects (22%) had metabolic syndrome according to both definitions, 31 (3.3%) only by the IDF criteria, and 5 (0.5%) only by the NCEP criteria. Participants fulfilling both proposals showed more adverse age and sex-adjusted measures of BMI, waist, HDL cholesterol, triglycerides, post-load glucose, HOMA-IR and plasminogen inhibitor activator-1 (PAI-1) than individuals exclusively satisfying the IDF criteria. Moreover, in contrast to subjects meeting both criteria, those that fulfilled only the IDF criteria had levels of BMI, waist, total and HDL cholesterol, post-load glucose, glycated HbA1c, C-reactive protein, PAI-1 and fibrinogen not significantly different from those observed in subjects without metabolic syndrome. CONCLUSION: The IDF definition identifies a surplus of individuals whose cardiovascular risk profile, particularly regarding to some non-traditional cardiovascular risk factors, is less adverse than that observed in subjects also diagnosed by the NCEP definition. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/18819785/Differences_in_traditional_and_emerging_cardiovascular_risk_factors_of_subjects_discordantly_classified_by_metabolic_syndrome_definitions_of_the_International_Diabetes_Federation_and_the_National_Cholesterol_Education_Program_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(08)00165-8 DB - PRIME DP - Unbound Medicine ER -