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[Sedative, hypnotic and antiseizure effects of compound gardenia oil and jujube seed oil in mice].
Nan Fang Yi Ke Da Xue Xue Bao. 2008 Aug; 28(9):1636-9.NF

Abstract

OBJECTIVE

To study the sedative, hypnotic and antiseizure effects of the compound preparation of gardenia oil and jujube seed oil in mice and investigate the interaction of the two drugs in this preparation.

METHODS

The compound preparation was administered intragastrically in mice, whose spontaneous activity was observed along with their tolerance of the preparation after long-term administration. The hypnotic effect of the compound was assessed by investigating the changes in the pentobarbital sodium-induced sleeping. The compound was tested for its antiseizure effect in mice with pentetrazole-induced clonic and tonic convulsion. Diazepam was used as the standard control in all experiments.

RESULTS

The jujube seed oil, the gardenia oil and their compound all inhibited spontaneous activities of the mice. Compared with diazepam, the compound showed slow action in producing the sedative effect, which increased gradually with prolonged drug administration without obvious drug tolerance responses. The compound and the two oils all showed synergistic action with pentobarbital sodium in inducing sleeping of the mice. Prescription study showed that the compound produced stronger sedative and hypnotic effects than either of the oils. The two oils and the compound did not show significant antiseizure effects in mice.

CONCLUSION

The compound of jujube seed oil and gardenia oil has sedative and hypnotic effects in mice, and the two oils in the compound show obvious synergistic effect.

Authors+Show Affiliations

Department of Pharmacology, Yan'an University, Yan'an, China. lbl_0812@163.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18819886

Citation

Li, Bao-li, et al. "[Sedative, Hypnotic and Antiseizure Effects of Compound Gardenia Oil and Jujube Seed Oil in Mice]." Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, vol. 28, no. 9, 2008, pp. 1636-9.
Li BL, Chen YH, Hu R, et al. [Sedative, hypnotic and antiseizure effects of compound gardenia oil and jujube seed oil in mice]. Nan Fang Yi Ke Da Xue Xue Bao. 2008;28(9):1636-9.
Li, B. L., Chen, Y. H., Hu, R., Tang, J. J., Zhao, L. M., & Yuan, B. X. (2008). [Sedative, hypnotic and antiseizure effects of compound gardenia oil and jujube seed oil in mice]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, 28(9), 1636-9.
Li BL, et al. [Sedative, Hypnotic and Antiseizure Effects of Compound Gardenia Oil and Jujube Seed Oil in Mice]. Nan Fang Yi Ke Da Xue Xue Bao. 2008;28(9):1636-9. PubMed PMID: 18819886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Sedative, hypnotic and antiseizure effects of compound gardenia oil and jujube seed oil in mice]. AU - Li,Bao-li, AU - Chen,Ya-hui, AU - Hu,Rui, AU - Tang,Jun-jie, AU - Zhao,Li-mei, AU - Yuan,Bing-xiang, PY - 2008/9/30/pubmed PY - 2009/4/7/medline PY - 2008/9/30/entrez SP - 1636 EP - 9 JF - Nan fang yi ke da xue xue bao = Journal of Southern Medical University JO - Nan Fang Yi Ke Da Xue Xue Bao VL - 28 IS - 9 N2 - OBJECTIVE: To study the sedative, hypnotic and antiseizure effects of the compound preparation of gardenia oil and jujube seed oil in mice and investigate the interaction of the two drugs in this preparation. METHODS: The compound preparation was administered intragastrically in mice, whose spontaneous activity was observed along with their tolerance of the preparation after long-term administration. The hypnotic effect of the compound was assessed by investigating the changes in the pentobarbital sodium-induced sleeping. The compound was tested for its antiseizure effect in mice with pentetrazole-induced clonic and tonic convulsion. Diazepam was used as the standard control in all experiments. RESULTS: The jujube seed oil, the gardenia oil and their compound all inhibited spontaneous activities of the mice. Compared with diazepam, the compound showed slow action in producing the sedative effect, which increased gradually with prolonged drug administration without obvious drug tolerance responses. The compound and the two oils all showed synergistic action with pentobarbital sodium in inducing sleeping of the mice. Prescription study showed that the compound produced stronger sedative and hypnotic effects than either of the oils. The two oils and the compound did not show significant antiseizure effects in mice. CONCLUSION: The compound of jujube seed oil and gardenia oil has sedative and hypnotic effects in mice, and the two oils in the compound show obvious synergistic effect. SN - 1673-4254 UR - https://www.unboundmedicine.com/medline/citation/18819886/[Sedative_hypnotic_and_antiseizure_effects_of_compound_gardenia_oil_and_jujube_seed_oil_in_mice]_ DB - PRIME DP - Unbound Medicine ER -