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[Comparison study on diagnostic and prognostic value of N-terminal probrain natriuretic peptide and atrium natriuretic peptide in chronic congestive heart failure].
Nan Fang Yi Ke Da Xue Xue Bao. 2008 Aug; 28(9):1740-2.NF

Abstract

OBJECTIVE

To investigate the diagnostic and prognostic value of N-terminal probrain natriuretic peptide(NT-proBNP)and atrium natriuretic peptide(ANP)in chronic congestive heart failure.

METHODS

One hundred and eighteen coronary heart disease patients were enrolled in the study. Among them 78 patients were accompanied by heart failure and 40 with no heart failure. Plasma NT-proBNP was determined with Elecsys Chemiluminescence Immunoassay method, and plasma ANP was determined with radioimmunoassay method.The results were compared with those of 40 healthy individuals. All patients were followed up accordingly.

RESULTS

Compared with patients with no heart failure and healthy individuals, the patients with heart failure had a higher plasma NT-proBNP and ANP contents(P<0.05). Cardiac function grade IV patients had a significantly higher plasma NT-proBNP than cardiac function grade II and III patients, and their plasma ANP level was significanthy higher than that of cardiac function grade III patients, but there was no significantly difference in ANP content between cardiac function grade IV and II.The diagnostic sensitivity of NT-proBNP and ANP was 91.25% and 73.46%, respectively. The diagnostic specificity of NT-proBNP and ANP was 90.25%, 80.33%, respectively. In the heart failure group, it was found that there was no significant difference in the plasma NT-proBNP and ANP between the deaths and surviving patients.

CONCLUSION

The diagnostic value of NT-proBNP in chronic heart failure is higher than that of ANP. According to our follow- up result, the plasma NT-proBNP and ANP can not be relied up on to predict short -term cardiogenic death in heart failure.

Authors+Show Affiliations

Department of Clinical Laboratory, People's Hospital of Guangdong Province, Guangzhou, China. DH8893@sohu.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

chi

PubMed ID

18819908

Citation

Dong, Hui, et al. "[Comparison Study On Diagnostic and Prognostic Value of N-terminal Probrain Natriuretic Peptide and Atrium Natriuretic Peptide in Chronic Congestive Heart Failure]." Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, vol. 28, no. 9, 2008, pp. 1740-2.
Dong H, Chen DQ, Wang Y, et al. [Comparison study on diagnostic and prognostic value of N-terminal probrain natriuretic peptide and atrium natriuretic peptide in chronic congestive heart failure]. Nan Fang Yi Ke Da Xue Xue Bao. 2008;28(9):1740-2.
Dong, H., Chen, D. Q., Wang, Y., & Li, M. (2008). [Comparison study on diagnostic and prognostic value of N-terminal probrain natriuretic peptide and atrium natriuretic peptide in chronic congestive heart failure]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, 28(9), 1740-2.
Dong H, et al. [Comparison Study On Diagnostic and Prognostic Value of N-terminal Probrain Natriuretic Peptide and Atrium Natriuretic Peptide in Chronic Congestive Heart Failure]. Nan Fang Yi Ke Da Xue Xue Bao. 2008;28(9):1740-2. PubMed PMID: 18819908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparison study on diagnostic and prognostic value of N-terminal probrain natriuretic peptide and atrium natriuretic peptide in chronic congestive heart failure]. AU - Dong,Hui, AU - Chen,Da-qiang, AU - Wang,Yan, AU - Li,Ming, PY - 2008/9/30/pubmed PY - 2009/4/7/medline PY - 2008/9/30/entrez SP - 1740 EP - 2 JF - Nan fang yi ke da xue xue bao = Journal of Southern Medical University JO - Nan Fang Yi Ke Da Xue Xue Bao VL - 28 IS - 9 N2 - OBJECTIVE: To investigate the diagnostic and prognostic value of N-terminal probrain natriuretic peptide(NT-proBNP)and atrium natriuretic peptide(ANP)in chronic congestive heart failure. METHODS: One hundred and eighteen coronary heart disease patients were enrolled in the study. Among them 78 patients were accompanied by heart failure and 40 with no heart failure. Plasma NT-proBNP was determined with Elecsys Chemiluminescence Immunoassay method, and plasma ANP was determined with radioimmunoassay method.The results were compared with those of 40 healthy individuals. All patients were followed up accordingly. RESULTS: Compared with patients with no heart failure and healthy individuals, the patients with heart failure had a higher plasma NT-proBNP and ANP contents(P<0.05). Cardiac function grade IV patients had a significantly higher plasma NT-proBNP than cardiac function grade II and III patients, and their plasma ANP level was significanthy higher than that of cardiac function grade III patients, but there was no significantly difference in ANP content between cardiac function grade IV and II.The diagnostic sensitivity of NT-proBNP and ANP was 91.25% and 73.46%, respectively. The diagnostic specificity of NT-proBNP and ANP was 90.25%, 80.33%, respectively. In the heart failure group, it was found that there was no significant difference in the plasma NT-proBNP and ANP between the deaths and surviving patients. CONCLUSION: The diagnostic value of NT-proBNP in chronic heart failure is higher than that of ANP. According to our follow- up result, the plasma NT-proBNP and ANP can not be relied up on to predict short -term cardiogenic death in heart failure. SN - 1673-4254 UR - https://www.unboundmedicine.com/medline/citation/18819908/[Comparison_study_on_diagnostic_and_prognostic_value_of_N_terminal_probrain_natriuretic_peptide_and_atrium_natriuretic_peptide_in_chronic_congestive_heart_failure]_ L2 - https://medlineplus.gov/heartfailure.html DB - PRIME DP - Unbound Medicine ER -