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Dietary plasma proteins, the intestinal immune system, and the barrier functions of the intestinal mucosa.
J Anim Sci 2009; 87(14 Suppl):E92-100JA

Abstract

The intestinal mucosa contributes to homeostasis by preventing the entrance of biological and chemical agents across the epithelium that could alter the stability of the system. This protective function is especially important at the time of weaning, when animals are exposed to infectious agents and to numerous stresses such as the change of environment and diet. Diets supplemented with spray-dried plasma or plasma protein fractions have been shown to improve growth performance of farm animals and have been proposed as an alternative to antibiotics. In this review, we summarize our findings on the mechanism of action of dietary plasma proteins using a rat model of intestinal inflammation, based on the administration of Staphylococcus aureus enterotoxin B (SEB). Staphylococcal enterotoxin B activates the gut-associated lymphoid tissue (GALT), increasing T-lymphocytes in Peyer's patches and the number of activated T lymphocytes in mesenteric lymph nodes (organized GALT). In the lamina propria SEB increased cytotoxic T gammadelta and natural killer cell populations of the diffuse GALT. Staphyloccocal enterotoxin B significantly increased proinflammatory cytokines in Peyer's patches and mucosa. Plasma protein supplements modulated the mucosal immune response in organized and diffuse GALT, protecting GALT from possible excessive activation by the SEB challenge. These effects are accompanied by a reduction of proinflammatory cytokine production, supporting the view that changes in cytokine production mediate the effects of dietary plasma proteins during intestinal inflammation. The increase in mucosal permeability and intestinal secretion induced by SEB was associated with decreased expression of mucosal tight-junction and adherent-junction proteins. Both plasma and plasma protein fractions prevented the effects of SEB on intestinal permeability, thus reducing the exposure of the host to microbial and food antigens across the interstitial space. These findings indicate that dietary plasma proteins modulate functional and structural properties of the intestinal mucosa.

Authors+Show Affiliations

Grup de Fisiologia i Nutrició Experimental, Departament de Fisiologia, Facultat de Farmàcia, Institut de Recerca en Nutrició i Seguretat Alimentària, Universitat de Barcelona, Spain. mmoreto@ub.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18820151

Citation

Moretó, M, and A Pérez-Bosque. "Dietary Plasma Proteins, the Intestinal Immune System, and the Barrier Functions of the Intestinal Mucosa." Journal of Animal Science, vol. 87, no. 14 Suppl, 2009, pp. E92-100.
Moretó M, Pérez-Bosque A. Dietary plasma proteins, the intestinal immune system, and the barrier functions of the intestinal mucosa. J Anim Sci. 2009;87(14 Suppl):E92-100.
Moretó, M., & Pérez-Bosque, A. (2009). Dietary plasma proteins, the intestinal immune system, and the barrier functions of the intestinal mucosa. Journal of Animal Science, 87(14 Suppl), pp. E92-100. doi:10.2527/jas.2008-1381.
Moretó M, Pérez-Bosque A. Dietary Plasma Proteins, the Intestinal Immune System, and the Barrier Functions of the Intestinal Mucosa. J Anim Sci. 2009;87(14 Suppl):E92-100. PubMed PMID: 18820151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary plasma proteins, the intestinal immune system, and the barrier functions of the intestinal mucosa. AU - Moretó,M, AU - Pérez-Bosque,A, Y1 - 2008/09/26/ PY - 2008/9/30/pubmed PY - 2009/5/19/medline PY - 2008/9/30/entrez SP - E92 EP - 100 JF - Journal of animal science JO - J. Anim. Sci. VL - 87 IS - 14 Suppl N2 - The intestinal mucosa contributes to homeostasis by preventing the entrance of biological and chemical agents across the epithelium that could alter the stability of the system. This protective function is especially important at the time of weaning, when animals are exposed to infectious agents and to numerous stresses such as the change of environment and diet. Diets supplemented with spray-dried plasma or plasma protein fractions have been shown to improve growth performance of farm animals and have been proposed as an alternative to antibiotics. In this review, we summarize our findings on the mechanism of action of dietary plasma proteins using a rat model of intestinal inflammation, based on the administration of Staphylococcus aureus enterotoxin B (SEB). Staphylococcal enterotoxin B activates the gut-associated lymphoid tissue (GALT), increasing T-lymphocytes in Peyer's patches and the number of activated T lymphocytes in mesenteric lymph nodes (organized GALT). In the lamina propria SEB increased cytotoxic T gammadelta and natural killer cell populations of the diffuse GALT. Staphyloccocal enterotoxin B significantly increased proinflammatory cytokines in Peyer's patches and mucosa. Plasma protein supplements modulated the mucosal immune response in organized and diffuse GALT, protecting GALT from possible excessive activation by the SEB challenge. These effects are accompanied by a reduction of proinflammatory cytokine production, supporting the view that changes in cytokine production mediate the effects of dietary plasma proteins during intestinal inflammation. The increase in mucosal permeability and intestinal secretion induced by SEB was associated with decreased expression of mucosal tight-junction and adherent-junction proteins. Both plasma and plasma protein fractions prevented the effects of SEB on intestinal permeability, thus reducing the exposure of the host to microbial and food antigens across the interstitial space. These findings indicate that dietary plasma proteins modulate functional and structural properties of the intestinal mucosa. SN - 1525-3163 UR - https://www.unboundmedicine.com/medline/citation/18820151/Dietary_plasma_proteins_the_intestinal_immune_system_and_the_barrier_functions_of_the_intestinal_mucosa_ L2 - https://academic.oup.com/jas/article-lookup/doi/10.2527/jas.2008-1381 DB - PRIME DP - Unbound Medicine ER -