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Heart rate and mortality from cardiovascular causes: a 12 year follow-up study of 379,843 men and women aged 40-45 years.
Eur Heart J. 2008 Nov; 29(22):2772-81.EH

Abstract

AIM

To study the relationship between heart rate and (a) all deaths and (b) cardiovascular deaths in a large cohort of middle-aged Norwegian men and women.

METHODS AND RESULTS

A prospective study of participants in cardiovascular surveys that were carried out in 1985-1999 and covered men and women aged 40-45 years in all counties except the capital, Oslo. In total, 180,353 men and 199,490 women aged 40-45 years without cardiovascular history or diabetes accrued 4 775 683 years of follow-up. There was a positive and graded association between heart rate and mortality from all causes, as well as between heart rate and deaths from cardiovascular disease (CVD), ischaemic heart disease, and stroke. However, these associations were greatly reduced when we adjusted for the main risk factors of disease. The hazard ratios for any death were reduced from 3.14 to 1.82 for men (95% CI, 1.62-2.04) and from 2.14 to 1.37 for women (95% CI, 1.19-1.59), when we compared > or =95 b.p.m. with <65 b.p.m. The corresponding figures for CVD were a reduction from 4.79 to 1.51 for men (95% CI, 1.21-1.87) and from 2.68 to 0.78 for women (95% CI, 0.53-1.15).

CONCLUSION

In this cohort of middle-aged men and women, a crude association between heart rate and death from CVDs was greatly weakened when we adjusted for the main risk factors of disease. This suggests that an increased heart rate in middle age may be a marker of high cardiovascular risk, but is not an independent risk factor.

Authors+Show Affiliations

The Norwegian Institute of Public Health, Nydalen, Oslo, Norway. aage.tverdal@fhi.noNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18820324

Citation

Tverdal, Aage, et al. "Heart Rate and Mortality From Cardiovascular Causes: a 12 Year Follow-up Study of 379,843 Men and Women Aged 40-45 Years." European Heart Journal, vol. 29, no. 22, 2008, pp. 2772-81.
Tverdal A, Hjellvik V, Selmer R. Heart rate and mortality from cardiovascular causes: a 12 year follow-up study of 379,843 men and women aged 40-45 years. Eur Heart J. 2008;29(22):2772-81.
Tverdal, A., Hjellvik, V., & Selmer, R. (2008). Heart rate and mortality from cardiovascular causes: a 12 year follow-up study of 379,843 men and women aged 40-45 years. European Heart Journal, 29(22), 2772-81. https://doi.org/10.1093/eurheartj/ehn435
Tverdal A, Hjellvik V, Selmer R. Heart Rate and Mortality From Cardiovascular Causes: a 12 Year Follow-up Study of 379,843 Men and Women Aged 40-45 Years. Eur Heart J. 2008;29(22):2772-81. PubMed PMID: 18820324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heart rate and mortality from cardiovascular causes: a 12 year follow-up study of 379,843 men and women aged 40-45 years. AU - Tverdal,Aage, AU - Hjellvik,Vidar, AU - Selmer,Randi, Y1 - 2008/09/27/ PY - 2008/9/30/pubmed PY - 2009/1/1/medline PY - 2008/9/30/entrez SP - 2772 EP - 81 JF - European heart journal JO - Eur. Heart J. VL - 29 IS - 22 N2 - AIM: To study the relationship between heart rate and (a) all deaths and (b) cardiovascular deaths in a large cohort of middle-aged Norwegian men and women. METHODS AND RESULTS: A prospective study of participants in cardiovascular surveys that were carried out in 1985-1999 and covered men and women aged 40-45 years in all counties except the capital, Oslo. In total, 180,353 men and 199,490 women aged 40-45 years without cardiovascular history or diabetes accrued 4 775 683 years of follow-up. There was a positive and graded association between heart rate and mortality from all causes, as well as between heart rate and deaths from cardiovascular disease (CVD), ischaemic heart disease, and stroke. However, these associations were greatly reduced when we adjusted for the main risk factors of disease. The hazard ratios for any death were reduced from 3.14 to 1.82 for men (95% CI, 1.62-2.04) and from 2.14 to 1.37 for women (95% CI, 1.19-1.59), when we compared > or =95 b.p.m. with <65 b.p.m. The corresponding figures for CVD were a reduction from 4.79 to 1.51 for men (95% CI, 1.21-1.87) and from 2.68 to 0.78 for women (95% CI, 0.53-1.15). CONCLUSION: In this cohort of middle-aged men and women, a crude association between heart rate and death from CVDs was greatly weakened when we adjusted for the main risk factors of disease. This suggests that an increased heart rate in middle age may be a marker of high cardiovascular risk, but is not an independent risk factor. SN - 1522-9645 UR - https://www.unboundmedicine.com/medline/citation/18820324/Heart_rate_and_mortality_from_cardiovascular_causes:_a_12_year_follow_up_study_of_379843_men_and_women_aged_40_45_years_ L2 - https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehn435 DB - PRIME DP - Unbound Medicine ER -