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Permanent intestinal failure.
Indian Pediatr. 2008 Sep; 45(9):753-63.IP

Abstract

CONTEXT

Intestinal failure (IF) requires the use of parenteral nutrition as long as it persists and may be in case of persistence an indication for intestinal transplantation.

EVIDENCE ACQUISITION

Literature search was performed both electronically and manually.

RESULTS AND CONCLUSIONS

Biological evaluation of IF is becoming possible with the use of plasma citrulline as a marker of intestinal mass. Short bowel syndrome (SBS) is the leading cause of intestinal failure in infants while few epidemiological data are available to date. Data on morbidity and mortality in pediatric patients with SBS are very limited while long-term outcome seems to be improving. Other causes of intestinal failure include neuro muscular intestinal disease and congenital disease of enterocyte development. The management of IF should include therapies adapted to each type and stage of IF based on a multidisciplinary approach, in centers involving pediatric surgery, pediatric gastroenterology, parenteral nutrition expertise, home parenteral nutrition program, and liver-intestinal transplantation experience. Timing for referral of patients in specialized centers remains a crucial issue. The main causes of IF are briefly reviewed emphasizing the medico-surgical strategy for prevention and care-provision, adapted to each type and stage of IF.

Authors+Show Affiliations

National Reference Center for Rare Digestive Diseases, Hospital Necker Enfants Malades, Universite Paris 5 Rene Descartes, Paris, France. olivier.goulet@nck.aphp.frNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18820382

Citation

Goulet, Olivier, et al. "Permanent Intestinal Failure." Indian Pediatrics, vol. 45, no. 9, 2008, pp. 753-63.
Goulet O, Fusaro F, Lacaille F, et al. Permanent intestinal failure. Indian Pediatr. 2008;45(9):753-63.
Goulet, O., Fusaro, F., Lacaille, F., & Sauvat, F. (2008). Permanent intestinal failure. Indian Pediatrics, 45(9), 753-63.
Goulet O, et al. Permanent Intestinal Failure. Indian Pediatr. 2008;45(9):753-63. PubMed PMID: 18820382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Permanent intestinal failure. AU - Goulet,Olivier, AU - Fusaro,Fabio, AU - Lacaille,Florence, AU - Sauvat,Frédérique, PY - 2008/9/30/pubmed PY - 2008/12/17/medline PY - 2008/9/30/entrez SP - 753 EP - 63 JF - Indian pediatrics JO - Indian Pediatr VL - 45 IS - 9 N2 - CONTEXT: Intestinal failure (IF) requires the use of parenteral nutrition as long as it persists and may be in case of persistence an indication for intestinal transplantation. EVIDENCE ACQUISITION: Literature search was performed both electronically and manually. RESULTS AND CONCLUSIONS: Biological evaluation of IF is becoming possible with the use of plasma citrulline as a marker of intestinal mass. Short bowel syndrome (SBS) is the leading cause of intestinal failure in infants while few epidemiological data are available to date. Data on morbidity and mortality in pediatric patients with SBS are very limited while long-term outcome seems to be improving. Other causes of intestinal failure include neuro muscular intestinal disease and congenital disease of enterocyte development. The management of IF should include therapies adapted to each type and stage of IF based on a multidisciplinary approach, in centers involving pediatric surgery, pediatric gastroenterology, parenteral nutrition expertise, home parenteral nutrition program, and liver-intestinal transplantation experience. Timing for referral of patients in specialized centers remains a crucial issue. The main causes of IF are briefly reviewed emphasizing the medico-surgical strategy for prevention and care-provision, adapted to each type and stage of IF. SN - 0019-6061 UR - https://www.unboundmedicine.com/medline/citation/18820382/Permanent_intestinal_failure_ DB - PRIME DP - Unbound Medicine ER -