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Daidzein-metabolizing phenotypes in relation to mammographic breast density among premenopausal women in the United States.
Breast Cancer Res Treat. 2009 Aug; 116(3):587-94.BC

Abstract

BACKGROUND

Mammographic breast density is an established marker of breast cancer risk, and is hormonally sensitive. Studies suggest that production of the daidzein metabolites equol and O-Desmethylangolensin (ODMA) may be associated with hormones and hormonally mediated factors, but few studies have assessed relationships between the capacity to produce these metabolites and breast density.

OBJECTIVE

To evaluate the relationship between equol- and ODMA-producer phenotypes and breast density in premenopausal women in the United States.

DESIGN

Two hundred and three women attended a clinic visit and 200 provided a urine sample following a 3 day soy challenge. Samples were analyzed for isoflavones by GC-MS to determine daidzein-metabolizing phenotypes. Percent density on recent (<14 month prior to their clinic visit) mammograms was assessed by one reader using a computer-assisted method. Multiple regression analysis was used to assess relationships between the production of equol and ODMA and breast density. Results 55(27.5%) and 182(91%) women were classed as equol- and ODMA-producers (>87.5 ng/ml urine), respectively. In unadjusted and adjusted analyses, there were no differences in breast density between producers and non-producers of either equol or ODMA (P > 0.05).

CONCLUSION

In this population of low-soy consuming premenopausal women, there were no associations between daidzein-metabolizing phenotypes and breast density, suggesting that these phenotypes per se do not influence premenopausal breast density.

Authors+Show Affiliations

Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA, charlotte.atkinson@bristol.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18821061

Citation

Atkinson, Charlotte, et al. "Daidzein-metabolizing Phenotypes in Relation to Mammographic Breast Density Among Premenopausal Women in the United States." Breast Cancer Research and Treatment, vol. 116, no. 3, 2009, pp. 587-94.
Atkinson C, Newton KM, Aiello Bowles EJ, et al. Daidzein-metabolizing phenotypes in relation to mammographic breast density among premenopausal women in the United States. Breast Cancer Res Treat. 2009;116(3):587-94.
Atkinson, C., Newton, K. M., Aiello Bowles, E. J., Lehman, C. D., Stanczyk, F. Z., Westerlind, K. C., Li, L., & Lampe, J. W. (2009). Daidzein-metabolizing phenotypes in relation to mammographic breast density among premenopausal women in the United States. Breast Cancer Research and Treatment, 116(3), 587-94. https://doi.org/10.1007/s10549-008-0199-7
Atkinson C, et al. Daidzein-metabolizing Phenotypes in Relation to Mammographic Breast Density Among Premenopausal Women in the United States. Breast Cancer Res Treat. 2009;116(3):587-94. PubMed PMID: 18821061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Daidzein-metabolizing phenotypes in relation to mammographic breast density among premenopausal women in the United States. AU - Atkinson,Charlotte, AU - Newton,Katherine M, AU - Aiello Bowles,Erin J, AU - Lehman,Constance D, AU - Stanczyk,Frank Z, AU - Westerlind,Kim C, AU - Li,Lin, AU - Lampe,Johanna W, Y1 - 2008/09/28/ PY - 2008/08/12/received PY - 2008/09/15/accepted PY - 2008/9/30/pubmed PY - 2009/9/30/medline PY - 2008/9/30/entrez SP - 587 EP - 94 JF - Breast cancer research and treatment JO - Breast Cancer Res Treat VL - 116 IS - 3 N2 - BACKGROUND: Mammographic breast density is an established marker of breast cancer risk, and is hormonally sensitive. Studies suggest that production of the daidzein metabolites equol and O-Desmethylangolensin (ODMA) may be associated with hormones and hormonally mediated factors, but few studies have assessed relationships between the capacity to produce these metabolites and breast density. OBJECTIVE: To evaluate the relationship between equol- and ODMA-producer phenotypes and breast density in premenopausal women in the United States. DESIGN: Two hundred and three women attended a clinic visit and 200 provided a urine sample following a 3 day soy challenge. Samples were analyzed for isoflavones by GC-MS to determine daidzein-metabolizing phenotypes. Percent density on recent (<14 month prior to their clinic visit) mammograms was assessed by one reader using a computer-assisted method. Multiple regression analysis was used to assess relationships between the production of equol and ODMA and breast density. Results 55(27.5%) and 182(91%) women were classed as equol- and ODMA-producers (>87.5 ng/ml urine), respectively. In unadjusted and adjusted analyses, there were no differences in breast density between producers and non-producers of either equol or ODMA (P > 0.05). CONCLUSION: In this population of low-soy consuming premenopausal women, there were no associations between daidzein-metabolizing phenotypes and breast density, suggesting that these phenotypes per se do not influence premenopausal breast density. SN - 1573-7217 UR - https://www.unboundmedicine.com/medline/citation/18821061/Daidzein_metabolizing_phenotypes_in_relation_to_mammographic_breast_density_among_premenopausal_women_in_the_United_States_ L2 - https://doi.org/10.1007/s10549-008-0199-7 DB - PRIME DP - Unbound Medicine ER -