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Optimization of chitosan succinate and chitosan phthalate microspheres for oral delivery of insulin using response surface methodology.
Pharm Dev Technol. 2009; 14(1):96-105.PD

Abstract

In the present study, a Box-Behnken experimental design was employed to statistically optimize the formulation parameters of chitosan phthalate and chitosan succinate microspheres preparation. These microspheres can be useful for oral insulin delivery system. The effects of three parameters namely polymer concentration, stirring speed and cross linking agent were studied. The fitted mathematical model allowed us to plot response surfaces curves and to determine optimal preparation conditions. Results clearly indicated that the crosslinking agent was the main factor influencing the insulin loading and releasing. The in vitro results indicated that chitosan succinate microspheres need high amount of crosslinking agent to control initial burst release compared to chitosan phthalate microspheres. The reason may be attributed that chitosan succinate is more hydrophilic than chitosan phthalate. The relative pharmacological efficacy for chitosan phthalate and chitosan succinate microspheres (18.66 +/- 3.84%, 16.24 +/- 4%) was almost three-fold higher than the efficacy of the oral insulin administration (4.68 +/- 1.52%). These findings suggest that these microspheres are promising carrier for oral insulin delivery system.

Authors+Show Affiliations

Department of Parmaceutics, Faculty of Parmacy, Hamdard University, New Delhi, India. ubaidnkl@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18821127

Citation

Ubaidulla, Udhumansha, et al. "Optimization of Chitosan Succinate and Chitosan Phthalate Microspheres for Oral Delivery of Insulin Using Response Surface Methodology." Pharmaceutical Development and Technology, vol. 14, no. 1, 2009, pp. 96-105.
Ubaidulla U, Khar RK, Ahmad FJ, et al. Optimization of chitosan succinate and chitosan phthalate microspheres for oral delivery of insulin using response surface methodology. Pharm Dev Technol. 2009;14(1):96-105.
Ubaidulla, U., Khar, R. K., Ahmad, F. J., & Tripathi, P. (2009). Optimization of chitosan succinate and chitosan phthalate microspheres for oral delivery of insulin using response surface methodology. Pharmaceutical Development and Technology, 14(1), 96-105. https://doi.org/10.1080/10837450802409461
Ubaidulla U, et al. Optimization of Chitosan Succinate and Chitosan Phthalate Microspheres for Oral Delivery of Insulin Using Response Surface Methodology. Pharm Dev Technol. 2009;14(1):96-105. PubMed PMID: 18821127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimization of chitosan succinate and chitosan phthalate microspheres for oral delivery of insulin using response surface methodology. AU - Ubaidulla,Udhumansha, AU - Khar,R K, AU - Ahmad,F J, AU - Tripathi,Purnima, PY - 2008/9/30/pubmed PY - 2009/5/9/medline PY - 2008/9/30/entrez SP - 96 EP - 105 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 14 IS - 1 N2 - In the present study, a Box-Behnken experimental design was employed to statistically optimize the formulation parameters of chitosan phthalate and chitosan succinate microspheres preparation. These microspheres can be useful for oral insulin delivery system. The effects of three parameters namely polymer concentration, stirring speed and cross linking agent were studied. The fitted mathematical model allowed us to plot response surfaces curves and to determine optimal preparation conditions. Results clearly indicated that the crosslinking agent was the main factor influencing the insulin loading and releasing. The in vitro results indicated that chitosan succinate microspheres need high amount of crosslinking agent to control initial burst release compared to chitosan phthalate microspheres. The reason may be attributed that chitosan succinate is more hydrophilic than chitosan phthalate. The relative pharmacological efficacy for chitosan phthalate and chitosan succinate microspheres (18.66 +/- 3.84%, 16.24 +/- 4%) was almost three-fold higher than the efficacy of the oral insulin administration (4.68 +/- 1.52%). These findings suggest that these microspheres are promising carrier for oral insulin delivery system. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/18821127/Optimization_of_chitosan_succinate_and_chitosan_phthalate_microspheres_for_oral_delivery_of_insulin_using_response_surface_methodology_ L2 - https://www.tandfonline.com/doi/full/10.1080/10837450802409461 DB - PRIME DP - Unbound Medicine ER -