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Does reactivity to stress cosegregate with subclinical psychosis? A general population twin study.
Acta Psychiatr Scand 2009; 119(1):45-53AP

Abstract

OBJECTIVE

This study assessed the relationship between stress reactivity (trait 1) and psychosis (trait 2) across genetically related persons (cross-twin, cross-trait design) to examine whether stress reactivity is an uncontaminated and unconfounded familial marker of psychosis risk.

METHOD

Reactivity to stress and subclinical psychotic experiences were assessed in 289 female, general population twin-pairs. Cross-trait, within-twin associations investigating the association between stress reactivity and subclinical psychotic experiences in each person, were calculated. In addition, cross-trait, cross-twin associations were calculated to assess whether stress reactivity in one twin was moderated by subclinical psychotic experiences in the co-twin.

RESULTS

Cross-trait, within-twin analyses showed significant associations between stress reactivity and subclinical psychotic experiences in each person. In addition, the cross-trait cross-twin analyses showed that stress reactivity in twin 1 was significantly moderated by subclinical experiences in the co-twin.

CONCLUSION

The results suggest that the psychosis phenotype cosegregates with increased emotional reactivity to stress in daily life.

Authors+Show Affiliations

Maastricht University-Psychiatry and Neuropsychology, Maastricht 6200MD, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Twin Study

Language

eng

PubMed ID

18822092

Citation

Lataster, T, et al. "Does Reactivity to Stress Cosegregate With Subclinical Psychosis? a General Population Twin Study." Acta Psychiatrica Scandinavica, vol. 119, no. 1, 2009, pp. 45-53.
Lataster T, Wichers M, Jacobs N, et al. Does reactivity to stress cosegregate with subclinical psychosis? A general population twin study. Acta Psychiatr Scand. 2009;119(1):45-53.
Lataster, T., Wichers, M., Jacobs, N., Mengelers, R., Derom, C., Thiery, E., ... Myin-Germeys, I. (2009). Does reactivity to stress cosegregate with subclinical psychosis? A general population twin study. Acta Psychiatrica Scandinavica, 119(1), pp. 45-53. doi:10.1111/j.1600-0447.2008.01263.x.
Lataster T, et al. Does Reactivity to Stress Cosegregate With Subclinical Psychosis? a General Population Twin Study. Acta Psychiatr Scand. 2009;119(1):45-53. PubMed PMID: 18822092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does reactivity to stress cosegregate with subclinical psychosis? A general population twin study. AU - Lataster,T, AU - Wichers,M, AU - Jacobs,N, AU - Mengelers,R, AU - Derom,C, AU - Thiery,E, AU - Van Os,J, AU - Myin-Germeys,I, Y1 - 2008/09/19/ PY - 2008/9/30/pubmed PY - 2009/4/7/medline PY - 2008/9/30/entrez SP - 45 EP - 53 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 119 IS - 1 N2 - OBJECTIVE: This study assessed the relationship between stress reactivity (trait 1) and psychosis (trait 2) across genetically related persons (cross-twin, cross-trait design) to examine whether stress reactivity is an uncontaminated and unconfounded familial marker of psychosis risk. METHOD: Reactivity to stress and subclinical psychotic experiences were assessed in 289 female, general population twin-pairs. Cross-trait, within-twin associations investigating the association between stress reactivity and subclinical psychotic experiences in each person, were calculated. In addition, cross-trait, cross-twin associations were calculated to assess whether stress reactivity in one twin was moderated by subclinical psychotic experiences in the co-twin. RESULTS: Cross-trait, within-twin analyses showed significant associations between stress reactivity and subclinical psychotic experiences in each person. In addition, the cross-trait cross-twin analyses showed that stress reactivity in twin 1 was significantly moderated by subclinical experiences in the co-twin. CONCLUSION: The results suggest that the psychosis phenotype cosegregates with increased emotional reactivity to stress in daily life. SN - 1600-0447 UR - https://www.unboundmedicine.com/medline/citation/18822092/Does_reactivity_to_stress_cosegregate_with_subclinical_psychosis_A_general_population_twin_study_ L2 - https://doi.org/10.1111/j.1600-0447.2008.01263.x DB - PRIME DP - Unbound Medicine ER -