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[Preparation of verapamil hydrochloride core-in-cup tablets with double-pulsatile and multi-phasic release].
Yao Xue Xue Bao. 2008 Jun; 43(6):652-6.YX

Abstract

To prepare verapamil hydrochloride (VH) core-in-cup tablets with tri-layered tablet and four-layered tablet as core tablets, separately, which can provide biphasic release with double-pulsatile and multi-phasic release, core tablets were prepared by direct compression method, and core-in-cup tablets by dry-compression coated technology. The parameter, time-lag (T(lag)), was used to evaluate the influence of factors, such as the weight of the top cover layer, the amount of hydroxypropylmethylcellulose (HPMC), and the compression load on VH release. With the increase of the weight and HPMC amount of the top cover layer, the first lag time T(lag1) was prolonged. The second lag time T(lag2) of core-in-cup tablet with four-layered tablet as core tablet increased with the increasing amount of HPMC K100M. With the increase of compression load among the range (6 - 10 kg x cm(-2)), the two lag times were prolonged. Core-in-cup tablets with double-pulsatile and multi-phasic release released VH after the first lag time (4 -5 h), then kept sustained release for 12 h or 13 h, finally released rapidly. The drug in the core-in-cup tablet only released from the top cover layer. T(lag) is determined by the erosion rate of the inhibitor layers (the top cover layer and the sustained-release layer of the multi-layer core tablet).

Authors+Show Affiliations

Li CJ
Pharmaceutical Research Institute, China Pharmaceutical University, Nanjing 210009, China.
Zhu JB
No affiliation info available
Yu WY
No affiliation info available

MeSH

Delayed-Action PreparationsDrug CarriersDrug CompoundingDrug Delivery SystemsExcipientsHypromellose DerivativesMethylcelluloseTabletsVerapamil

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18822971

Citation

Li, Chang-Jun, et al. "[Preparation of Verapamil Hydrochloride Core-in-cup Tablets With Double-pulsatile and Multi-phasic Release]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 43, no. 6, 2008, pp. 652-6.
Li CJ, Zhu JB, Yu WY. [Preparation of verapamil hydrochloride core-in-cup tablets with double-pulsatile and multi-phasic release]. Yao Xue Xue Bao. 2008;43(6):652-6.
Li, C. J., Zhu, J. B., & Yu, W. Y. (2008). [Preparation of verapamil hydrochloride core-in-cup tablets with double-pulsatile and multi-phasic release]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 43(6), 652-6.
Li CJ, Zhu JB, Yu WY. [Preparation of Verapamil Hydrochloride Core-in-cup Tablets With Double-pulsatile and Multi-phasic Release]. Yao Xue Xue Bao. 2008;43(6):652-6. PubMed PMID: 18822971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Preparation of verapamil hydrochloride core-in-cup tablets with double-pulsatile and multi-phasic release]. AU - Li,Chang-Jun, AU - Zhu,Jia-Bi, AU - Yu,Wang-Yang, PY - 2008/10/1/pubmed PY - 2009/9/18/medline PY - 2008/10/1/entrez SP - 652 EP - 6 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 43 IS - 6 N2 - To prepare verapamil hydrochloride (VH) core-in-cup tablets with tri-layered tablet and four-layered tablet as core tablets, separately, which can provide biphasic release with double-pulsatile and multi-phasic release, core tablets were prepared by direct compression method, and core-in-cup tablets by dry-compression coated technology. The parameter, time-lag (T(lag)), was used to evaluate the influence of factors, such as the weight of the top cover layer, the amount of hydroxypropylmethylcellulose (HPMC), and the compression load on VH release. With the increase of the weight and HPMC amount of the top cover layer, the first lag time T(lag1) was prolonged. The second lag time T(lag2) of core-in-cup tablet with four-layered tablet as core tablet increased with the increasing amount of HPMC K100M. With the increase of compression load among the range (6 - 10 kg x cm(-2)), the two lag times were prolonged. Core-in-cup tablets with double-pulsatile and multi-phasic release released VH after the first lag time (4 -5 h), then kept sustained release for 12 h or 13 h, finally released rapidly. The drug in the core-in-cup tablet only released from the top cover layer. T(lag) is determined by the erosion rate of the inhibitor layers (the top cover layer and the sustained-release layer of the multi-layer core tablet). SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/18822971/[Preparation_of_verapamil_hydrochloride_core_in_cup_tablets_with_double_pulsatile_and_multi_phasic_release]_ DB - PRIME DP - Unbound Medicine ER -