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Risk of radiation-related salivary gland carcinomas among survivors of Hodgkin lymphoma: a population-based analysis.
Cancer 2008; 113(11):3153-9C

Abstract

BACKGROUND

Radiotherapy for Hodgkin lymphoma (HL) increases the risk of salivary gland carcinomas (SGC). To the authors' knowledge, however, the magnitude of the risk has not been assessed to date.

METHODS

The risks of SGC among 20,928 1-year survivors of HL who were diagnosed between 1973 and 2003 were evaluated in 11 population-based cancer registry areas of the Surveillance, Epidemiology, and End Results (SEER) program. Observed-to-expected ratios (O/E) were assessed by radiation treatment, sex, age at the time of HL diagnosis, calendar year of diagnosis, attained age, time since HL diagnosis, histologic type of SGC, and site of occurrence in the major salivary glands.

RESULTS

Among 11,047 HL patients who received radiotherapy as part of their initial treatment for HL, 21 developed subsequent invasive SGC (O/E = 16.9; 95% confidence interval [95% CI], 10.4-25.8). The risk of radiation-related SGC was highest for younger HL patients (age <20 years) (O/E = 45.5; 95% CI, 12.4-116.5) and among 10-year survivors (O/E = 23.9; 95% CI, 13.1-40.1), with risks remaining elevated for at least 2 decades after irradiation. Significant differences in risk by histologic type were observed, with a particularly high risk of developing mucoepidermoid carcinomas (O = 14; O/E = 44.2 [95% CI, 24.2-74.2]) and adenocarcinomas (O = 4; O/E = 30.6 [95% CI, 8.3-78.2]) noted.

CONCLUSIONS

HL patients treated with radiotherapy experienced a significantly increased risk of SGC, particularly when exposed at young ages or for at least 2 decades after exposure. Although the results of the current study reflect the late effects of former HL treatment approaches, they point to the importance of long-term follow-up and a heightened awareness of SGC risk in this population.

Authors+Show Affiliations

Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. boukherh@mail.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

18823043

Citation

Boukheris, Houda, et al. "Risk of Radiation-related Salivary Gland Carcinomas Among Survivors of Hodgkin Lymphoma: a Population-based Analysis." Cancer, vol. 113, no. 11, 2008, pp. 3153-9.
Boukheris H, Ron E, Dores GM, et al. Risk of radiation-related salivary gland carcinomas among survivors of Hodgkin lymphoma: a population-based analysis. Cancer. 2008;113(11):3153-9.
Boukheris, H., Ron, E., Dores, G. M., Stovall, M., Smith, S. A., & Curtis, R. E. (2008). Risk of radiation-related salivary gland carcinomas among survivors of Hodgkin lymphoma: a population-based analysis. Cancer, 113(11), pp. 3153-9. doi:10.1002/cncr.23918.
Boukheris H, et al. Risk of Radiation-related Salivary Gland Carcinomas Among Survivors of Hodgkin Lymphoma: a Population-based Analysis. Cancer. 2008 Dec 1;113(11):3153-9. PubMed PMID: 18823043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of radiation-related salivary gland carcinomas among survivors of Hodgkin lymphoma: a population-based analysis. AU - Boukheris,Houda, AU - Ron,Elaine, AU - Dores,Graça M, AU - Stovall,Marilyn, AU - Smith,Susan A, AU - Curtis,Rochelle E, PY - 2008/10/1/pubmed PY - 2009/1/14/medline PY - 2008/10/1/entrez SP - 3153 EP - 9 JF - Cancer JO - Cancer VL - 113 IS - 11 N2 - BACKGROUND: Radiotherapy for Hodgkin lymphoma (HL) increases the risk of salivary gland carcinomas (SGC). To the authors' knowledge, however, the magnitude of the risk has not been assessed to date. METHODS: The risks of SGC among 20,928 1-year survivors of HL who were diagnosed between 1973 and 2003 were evaluated in 11 population-based cancer registry areas of the Surveillance, Epidemiology, and End Results (SEER) program. Observed-to-expected ratios (O/E) were assessed by radiation treatment, sex, age at the time of HL diagnosis, calendar year of diagnosis, attained age, time since HL diagnosis, histologic type of SGC, and site of occurrence in the major salivary glands. RESULTS: Among 11,047 HL patients who received radiotherapy as part of their initial treatment for HL, 21 developed subsequent invasive SGC (O/E = 16.9; 95% confidence interval [95% CI], 10.4-25.8). The risk of radiation-related SGC was highest for younger HL patients (age <20 years) (O/E = 45.5; 95% CI, 12.4-116.5) and among 10-year survivors (O/E = 23.9; 95% CI, 13.1-40.1), with risks remaining elevated for at least 2 decades after irradiation. Significant differences in risk by histologic type were observed, with a particularly high risk of developing mucoepidermoid carcinomas (O = 14; O/E = 44.2 [95% CI, 24.2-74.2]) and adenocarcinomas (O = 4; O/E = 30.6 [95% CI, 8.3-78.2]) noted. CONCLUSIONS: HL patients treated with radiotherapy experienced a significantly increased risk of SGC, particularly when exposed at young ages or for at least 2 decades after exposure. Although the results of the current study reflect the late effects of former HL treatment approaches, they point to the importance of long-term follow-up and a heightened awareness of SGC risk in this population. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/18823043/Risk_of_radiation_related_salivary_gland_carcinomas_among_survivors_of_Hodgkin_lymphoma:_a_population_based_analysis_ L2 - https://doi.org/10.1002/cncr.23918 DB - PRIME DP - Unbound Medicine ER -