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Reduced factor VII and factor VIII levels and prolonged thrombin-generation times during a healthy diet in middle-aged women with mild to moderate cardiovascular disease risk.
J Thromb Haemost. 2008 Dec; 6(12):2088-94.JT

Abstract

BACKGROUND

No experimental study has investigated the effect of whole-diet therapies on a wide range of hemostatic parameters, and their relationship with metabolic and inflammatory markers. Such information was sought in middle-aged women with moderate cardiovascular disease (CVD) risk subjected to an integrated healthy diet.

METHODS

Forty-nine premenopausal women were screened for C-reactive protein levels > or =1 mg L(-1) and at least one additional CVD risk factor. Sixteen women (age: 43-54 years) were selected and received a 12-week diet (four phases) integrating National Cholesterol Education Program-Adult Treatment Panel-III recommendations with components of a Mediterranean-style diet.

RESULTS

We observed a reduction in body mass index (BMI) (P = 0.001), waist circumference (P = 0.005), total (P = 0.011) and low-density lipoprotein (LDL) cholesterol levels (P = 0.035). Antigen levels of coagulation factor (F)VII (P = 0.003) and FVIII (P = 0.005) were clearly reduced by dietary intervention, which also appeared to decrease circulating tissue factor but not fibrinogen and von Willebrand factor (VWF) antigen levels. Levels of FVIII and tumor necrosis factor-alpha, among the inflammation markers, showed the highest correlation, particularly before the intervention (r = 0.55, P = 0.032). Only this cytokine influenced FVIII variation over time, thus highlighting new relations between coagulation and cellular components of inflammation. The functional effect of diet on coagulation was indicated by markedly prolonged thrombin generation initiation and propagation times (lag time, P = 0.002; time to peak, P = 0.005).

CONCLUSIONS

The changes observed in coagulation initiation and amplification phases, body composition and lipid profile could translate into a remarkable decrease in the risk for cardiovascular disease. Our observations suggest novel relationships between coagulation and inflammatory components.

Authors+Show Affiliations

Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18823339

Citation

Passaro, A, et al. "Reduced Factor VII and Factor VIII Levels and Prolonged Thrombin-generation Times During a Healthy Diet in Middle-aged Women With Mild to Moderate Cardiovascular Disease Risk." Journal of Thrombosis and Haemostasis : JTH, vol. 6, no. 12, 2008, pp. 2088-94.
Passaro A, Calzavarini S, Volpato S, et al. Reduced factor VII and factor VIII levels and prolonged thrombin-generation times during a healthy diet in middle-aged women with mild to moderate cardiovascular disease risk. J Thromb Haemost. 2008;6(12):2088-94.
Passaro, A., Calzavarini, S., Volpato, S., Caruso, P., Poli, A., Fellin, R., & Bernardi, F. (2008). Reduced factor VII and factor VIII levels and prolonged thrombin-generation times during a healthy diet in middle-aged women with mild to moderate cardiovascular disease risk. Journal of Thrombosis and Haemostasis : JTH, 6(12), 2088-94. https://doi.org/10.1111/j.1538-7836.2008.03158.x
Passaro A, et al. Reduced Factor VII and Factor VIII Levels and Prolonged Thrombin-generation Times During a Healthy Diet in Middle-aged Women With Mild to Moderate Cardiovascular Disease Risk. J Thromb Haemost. 2008;6(12):2088-94. PubMed PMID: 18823339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced factor VII and factor VIII levels and prolonged thrombin-generation times during a healthy diet in middle-aged women with mild to moderate cardiovascular disease risk. AU - Passaro,A, AU - Calzavarini,S, AU - Volpato,S, AU - Caruso,P, AU - Poli,A, AU - Fellin,R, AU - Bernardi,F, Y1 - 2008/09/23/ PY - 2008/10/1/pubmed PY - 2009/2/10/medline PY - 2008/10/1/entrez SP - 2088 EP - 94 JF - Journal of thrombosis and haemostasis : JTH JO - J Thromb Haemost VL - 6 IS - 12 N2 - BACKGROUND: No experimental study has investigated the effect of whole-diet therapies on a wide range of hemostatic parameters, and their relationship with metabolic and inflammatory markers. Such information was sought in middle-aged women with moderate cardiovascular disease (CVD) risk subjected to an integrated healthy diet. METHODS: Forty-nine premenopausal women were screened for C-reactive protein levels > or =1 mg L(-1) and at least one additional CVD risk factor. Sixteen women (age: 43-54 years) were selected and received a 12-week diet (four phases) integrating National Cholesterol Education Program-Adult Treatment Panel-III recommendations with components of a Mediterranean-style diet. RESULTS: We observed a reduction in body mass index (BMI) (P = 0.001), waist circumference (P = 0.005), total (P = 0.011) and low-density lipoprotein (LDL) cholesterol levels (P = 0.035). Antigen levels of coagulation factor (F)VII (P = 0.003) and FVIII (P = 0.005) were clearly reduced by dietary intervention, which also appeared to decrease circulating tissue factor but not fibrinogen and von Willebrand factor (VWF) antigen levels. Levels of FVIII and tumor necrosis factor-alpha, among the inflammation markers, showed the highest correlation, particularly before the intervention (r = 0.55, P = 0.032). Only this cytokine influenced FVIII variation over time, thus highlighting new relations between coagulation and cellular components of inflammation. The functional effect of diet on coagulation was indicated by markedly prolonged thrombin generation initiation and propagation times (lag time, P = 0.002; time to peak, P = 0.005). CONCLUSIONS: The changes observed in coagulation initiation and amplification phases, body composition and lipid profile could translate into a remarkable decrease in the risk for cardiovascular disease. Our observations suggest novel relationships between coagulation and inflammatory components. SN - 1538-7836 UR - https://www.unboundmedicine.com/medline/citation/18823339/Reduced_factor_VII_and_factor_VIII_levels_and_prolonged_thrombin_generation_times_during_a_healthy_diet_in_middle_aged_women_with_mild_to_moderate_cardiovascular_disease_risk_ L2 - https://doi.org/10.1111/j.1538-7836.2008.03158.x DB - PRIME DP - Unbound Medicine ER -