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Intrahepatic regulatory T cells are phenotypically distinct from their peripheral counterparts in chronic HBV patients.
Clin Immunol. 2008 Dec; 129(3):419-27.CI

Abstract

Peripheral blood CD4+CD25+ regulatory T cells (Treg) prevent the development of strong HBV-specific T cell responses in vitro. In this study, we examined the phenotype of FoxP3+ regulatory T cells in the liver of patients with a chronic HBV infection. We showed that the liver contained a population of CD4+FoxP3+ cells that did not express CD25, while these cells were absent from peripheral blood. Interestingly, intrahepatic CD25-FoxP3+CD4+ T cells demonstrated lower expression of HLA-DR and CTLA-4 as compared to their CD25+ counterparts. Patients with a high viral load have a higher proportion of regulatory T cells in the liver, but not in blood, compared to patients with a low viral load. In conclusion, the intrahepatic Treg are phenotypically distinct from peripheral blood Treg. Our data suggest that the higher proportion of intrahepatic Treg observed in patients with a high viral load may explain the lack of control of viral replication.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18823821

Citation

Stoop, Jeroen N., et al. "Intrahepatic Regulatory T Cells Are Phenotypically Distinct From Their Peripheral Counterparts in Chronic HBV Patients." Clinical Immunology (Orlando, Fla.), vol. 129, no. 3, 2008, pp. 419-27.
Stoop JN, Claassen MA, Woltman AM, et al. Intrahepatic regulatory T cells are phenotypically distinct from their peripheral counterparts in chronic HBV patients. Clin Immunol. 2008;129(3):419-27.
Stoop, J. N., Claassen, M. A., Woltman, A. M., Binda, R. S., Kuipers, E. J., Janssen, H. L., van der Molen, R. G., & Boonstra, A. (2008). Intrahepatic regulatory T cells are phenotypically distinct from their peripheral counterparts in chronic HBV patients. Clinical Immunology (Orlando, Fla.), 129(3), 419-27. https://doi.org/10.1016/j.clim.2008.07.029
Stoop JN, et al. Intrahepatic Regulatory T Cells Are Phenotypically Distinct From Their Peripheral Counterparts in Chronic HBV Patients. Clin Immunol. 2008;129(3):419-27. PubMed PMID: 18823821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrahepatic regulatory T cells are phenotypically distinct from their peripheral counterparts in chronic HBV patients. AU - Stoop,Jeroen N, AU - Claassen,Mark A A, AU - Woltman,Andrea M, AU - Binda,Rekha S, AU - Kuipers,Ernst J, AU - Janssen,Harry L A, AU - van der Molen,Renate G, AU - Boonstra,Andre, Y1 - 2008/09/26/ PY - 2008/06/10/received PY - 2008/07/20/revised PY - 2008/07/24/accepted PY - 2008/10/1/pubmed PY - 2008/12/17/medline PY - 2008/10/1/entrez SP - 419 EP - 27 JF - Clinical immunology (Orlando, Fla.) JO - Clin. Immunol. VL - 129 IS - 3 N2 - Peripheral blood CD4+CD25+ regulatory T cells (Treg) prevent the development of strong HBV-specific T cell responses in vitro. In this study, we examined the phenotype of FoxP3+ regulatory T cells in the liver of patients with a chronic HBV infection. We showed that the liver contained a population of CD4+FoxP3+ cells that did not express CD25, while these cells were absent from peripheral blood. Interestingly, intrahepatic CD25-FoxP3+CD4+ T cells demonstrated lower expression of HLA-DR and CTLA-4 as compared to their CD25+ counterparts. Patients with a high viral load have a higher proportion of regulatory T cells in the liver, but not in blood, compared to patients with a low viral load. In conclusion, the intrahepatic Treg are phenotypically distinct from peripheral blood Treg. Our data suggest that the higher proportion of intrahepatic Treg observed in patients with a high viral load may explain the lack of control of viral replication. SN - 1521-7035 UR - https://www.unboundmedicine.com/medline/citation/18823821/Intrahepatic_regulatory_T_cells_are_phenotypically_distinct_from_their_peripheral_counterparts_in_chronic_HBV_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6616(08)00757-2 DB - PRIME DP - Unbound Medicine ER -