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Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease?
Free Radic Biol Med 2008; 45(10):1375-83FR

Abstract

Neurodegenerative diseases share various pathological features, such as accumulation of aberrant protein aggregates, microglial activation, and mitochondrial dysfunction. These pathological processes are associated with generation of reactive oxygen species (ROS), which cause oxidative stress and subsequent damage to essential molecules, such as lipids, proteins, and DNA. Hence, enhanced ROS production and oxidative injury play a cardinal role in the onset and progression of neurodegenerative disorders. To maintain a proper redox balance, the central nervous system is endowed with an antioxidant defense mechanism consisting of endogenous antioxidant enzymes. Expression of most antioxidant enzymes is tightly controlled by the antioxidant response element (ARE) and is activated by nuclear factor E2-related factor 2 (Nrf2). In past years reports have highlighted the protective effects of Nrf2 activation in reducing oxidative stress in both in vitro and in vivo models of neurodegenerative disorders. Here we provide an overview of the involvement of ROS-induced oxidative damage in Alzheimer's disease, Parkinson's disease, and Huntington's disease and we discuss the potential therapeutic effects of antioxidant enzymes and compounds that activate the Nrf2-ARE pathway.

Authors+Show Affiliations

Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18824091

Citation

de Vries, Helga E., et al. "Nrf2-induced Antioxidant Protection: a Promising Target to Counteract ROS-mediated Damage in Neurodegenerative Disease?" Free Radical Biology & Medicine, vol. 45, no. 10, 2008, pp. 1375-83.
de Vries HE, Witte M, Hondius D, et al. Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease? Free Radic Biol Med. 2008;45(10):1375-83.
de Vries, H. E., Witte, M., Hondius, D., Rozemuller, A. J., Drukarch, B., Hoozemans, J., & van Horssen, J. (2008). Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease? Free Radical Biology & Medicine, 45(10), pp. 1375-83. doi:10.1016/j.freeradbiomed.2008.09.001.
de Vries HE, et al. Nrf2-induced Antioxidant Protection: a Promising Target to Counteract ROS-mediated Damage in Neurodegenerative Disease. Free Radic Biol Med. 2008 Nov 15;45(10):1375-83. PubMed PMID: 18824091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease? AU - de Vries,Helga E, AU - Witte,Maarten, AU - Hondius,David, AU - Rozemuller,Annemieke J M, AU - Drukarch,Benjamin, AU - Hoozemans,Jeroen, AU - van Horssen,Jack, Y1 - 2008/09/13/ PY - 2008/08/05/received PY - 2008/09/03/revised PY - 2008/09/03/accepted PY - 2008/10/1/pubmed PY - 2009/3/25/medline PY - 2008/10/1/entrez SP - 1375 EP - 83 JF - Free radical biology & medicine JO - Free Radic. Biol. Med. VL - 45 IS - 10 N2 - Neurodegenerative diseases share various pathological features, such as accumulation of aberrant protein aggregates, microglial activation, and mitochondrial dysfunction. These pathological processes are associated with generation of reactive oxygen species (ROS), which cause oxidative stress and subsequent damage to essential molecules, such as lipids, proteins, and DNA. Hence, enhanced ROS production and oxidative injury play a cardinal role in the onset and progression of neurodegenerative disorders. To maintain a proper redox balance, the central nervous system is endowed with an antioxidant defense mechanism consisting of endogenous antioxidant enzymes. Expression of most antioxidant enzymes is tightly controlled by the antioxidant response element (ARE) and is activated by nuclear factor E2-related factor 2 (Nrf2). In past years reports have highlighted the protective effects of Nrf2 activation in reducing oxidative stress in both in vitro and in vivo models of neurodegenerative disorders. Here we provide an overview of the involvement of ROS-induced oxidative damage in Alzheimer's disease, Parkinson's disease, and Huntington's disease and we discuss the potential therapeutic effects of antioxidant enzymes and compounds that activate the Nrf2-ARE pathway. SN - 0891-5849 UR - https://www.unboundmedicine.com/medline/citation/18824091/Nrf2_induced_antioxidant_protection:_a_promising_target_to_counteract_ROS_mediated_damage_in_neurodegenerative_disease L2 - https://linkinghub.elsevier.com/retrieve/pii/S0891-5849(08)00513-3 DB - PRIME DP - Unbound Medicine ER -