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High-molecular-weight adiponectin and leptin levels in cord blood are associated with anthropometric measurements at birth.
Horm Res 2008; 70(5):268-72HR

Abstract

AIMS

High-molecular-weight adiponectin (HMW-ad) is an active form of adiponectin. No information is available with respect to HMW-ad in neonates. The aims of this study were to examine whether HMW-ad is present in cord blood, to define the association between the concentrations of cord blood HMW-ad and leptin, and their correlation with anthropometric measurements of term neonates at birth.

METHODS

Venous cord blood samples were obtained from 135 term healthy neonates (birth weight 2,261-4,164 g) born at Showa University Hospital. Total adiponectin (T-ad), HMW-ad and leptin levels were measured by ELISA.

RESULTS

HMW-ad levels were 14.9 +/- 5.8 microg/ml and the ratio of HMW-ad to T-ad was 0.49 +/- 0.15. In a multiple regression analysis, cord blood HMW-ad levels were a significant predictor of birth weight and birth length, and leptin level was a significant predictor of birth weight and birth weight to body length ratio. There was a significant relationship between concentrations of HMW-ad and leptin controlling for sex, gestational age and birth weight.

CONCLUSION

These results show that HMW-ad exists as a half of T-ad in the cord blood. Leptin and HMW-ad may regulate synergistically fetal growth.

Authors+Show Affiliations

Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18824864

Citation

Inoue, Makoto, et al. "High-molecular-weight Adiponectin and Leptin Levels in Cord Blood Are Associated With Anthropometric Measurements at Birth." Hormone Research, vol. 70, no. 5, 2008, pp. 268-72.
Inoue M, Itabashi K, Nakano Y, et al. High-molecular-weight adiponectin and leptin levels in cord blood are associated with anthropometric measurements at birth. Horm Res. 2008;70(5):268-72.
Inoue, M., Itabashi, K., Nakano, Y., Nakano, Y., & Tobe, T. (2008). High-molecular-weight adiponectin and leptin levels in cord blood are associated with anthropometric measurements at birth. Hormone Research, 70(5), pp. 268-72. doi:10.1159/000157872.
Inoue M, et al. High-molecular-weight Adiponectin and Leptin Levels in Cord Blood Are Associated With Anthropometric Measurements at Birth. Horm Res. 2008;70(5):268-72. PubMed PMID: 18824864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-molecular-weight adiponectin and leptin levels in cord blood are associated with anthropometric measurements at birth. AU - Inoue,Makoto, AU - Itabashi,Kazuo, AU - Nakano,Yuya, AU - Nakano,Yasuko, AU - Tobe,Takashi, Y1 - 2008/09/30/ PY - 2007/07/30/received PY - 2007/12/04/accepted PY - 2008/10/1/pubmed PY - 2009/1/22/medline PY - 2008/10/1/entrez SP - 268 EP - 72 JF - Hormone research JO - Horm. Res. VL - 70 IS - 5 N2 - AIMS: High-molecular-weight adiponectin (HMW-ad) is an active form of adiponectin. No information is available with respect to HMW-ad in neonates. The aims of this study were to examine whether HMW-ad is present in cord blood, to define the association between the concentrations of cord blood HMW-ad and leptin, and their correlation with anthropometric measurements of term neonates at birth. METHODS: Venous cord blood samples were obtained from 135 term healthy neonates (birth weight 2,261-4,164 g) born at Showa University Hospital. Total adiponectin (T-ad), HMW-ad and leptin levels were measured by ELISA. RESULTS: HMW-ad levels were 14.9 +/- 5.8 microg/ml and the ratio of HMW-ad to T-ad was 0.49 +/- 0.15. In a multiple regression analysis, cord blood HMW-ad levels were a significant predictor of birth weight and birth length, and leptin level was a significant predictor of birth weight and birth weight to body length ratio. There was a significant relationship between concentrations of HMW-ad and leptin controlling for sex, gestational age and birth weight. CONCLUSION: These results show that HMW-ad exists as a half of T-ad in the cord blood. Leptin and HMW-ad may regulate synergistically fetal growth. SN - 1423-0046 UR - https://www.unboundmedicine.com/medline/citation/18824864/High_molecular_weight_adiponectin_and_leptin_levels_in_cord_blood_are_associated_with_anthropometric_measurements_at_birth_ L2 - https://www.karger.com?DOI=10.1159/000157872 DB - PRIME DP - Unbound Medicine ER -