Tags

Type your tag names separated by a space and hit enter

Gestational diabetes insipidus and intrauterine fetal death of monochorionic twins.
J Perinatol. 2008 Oct; 28(10):712-4.JP

Abstract

Gestational diabetes insipidus (GDI) is a rare disorder. The onset is usually in the third trimester of pregnancy. We present a 24-year-old primigravida in her 35th week of a monochorionic-diamniotic twin pregnancy. The patient presented with intrauterine death of both twins accompanied by HELLP syndrome, hypernatremia and hemoconcentration. Urine osmolality below that of the plasma suggested GDI. 1-deamino-8D-arginine vasopressin (dDAVP) treatment was started with a quick response. GDI is probably the result of excessive activity of placental vasopressinase. In cases of liver dysfunction, the clearance rate of vasopressinase decreases, explaining the association of GDI with acute fatty liver and HELLP syndrome. Alert to this diagnosis, its evaluation and treatment is important.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Sava,, Israel. wiserniv@netvision.net.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18825149

Citation

Wiser, A, et al. "Gestational Diabetes Insipidus and Intrauterine Fetal Death of Monochorionic Twins." Journal of Perinatology : Official Journal of the California Perinatal Association, vol. 28, no. 10, 2008, pp. 712-4.
Wiser A, Hershko-Klement A, Fishman A, et al. Gestational diabetes insipidus and intrauterine fetal death of monochorionic twins. J Perinatol. 2008;28(10):712-4.
Wiser, A., Hershko-Klement, A., Fishman, A., Nachasch, N., & Fejgin, M. (2008). Gestational diabetes insipidus and intrauterine fetal death of monochorionic twins. Journal of Perinatology : Official Journal of the California Perinatal Association, 28(10), 712-4. https://doi.org/10.1038/jp.2008.95
Wiser A, et al. Gestational Diabetes Insipidus and Intrauterine Fetal Death of Monochorionic Twins. J Perinatol. 2008;28(10):712-4. PubMed PMID: 18825149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gestational diabetes insipidus and intrauterine fetal death of monochorionic twins. AU - Wiser,A, AU - Hershko-Klement,A, AU - Fishman,A, AU - Nachasch,N, AU - Fejgin,M, PY - 2008/10/1/pubmed PY - 2009/2/12/medline PY - 2008/10/1/entrez SP - 712 EP - 4 JF - Journal of perinatology : official journal of the California Perinatal Association JO - J Perinatol VL - 28 IS - 10 N2 - Gestational diabetes insipidus (GDI) is a rare disorder. The onset is usually in the third trimester of pregnancy. We present a 24-year-old primigravida in her 35th week of a monochorionic-diamniotic twin pregnancy. The patient presented with intrauterine death of both twins accompanied by HELLP syndrome, hypernatremia and hemoconcentration. Urine osmolality below that of the plasma suggested GDI. 1-deamino-8D-arginine vasopressin (dDAVP) treatment was started with a quick response. GDI is probably the result of excessive activity of placental vasopressinase. In cases of liver dysfunction, the clearance rate of vasopressinase decreases, explaining the association of GDI with acute fatty liver and HELLP syndrome. Alert to this diagnosis, its evaluation and treatment is important. SN - 1476-5543 UR - https://www.unboundmedicine.com/medline/citation/18825149/Gestational_diabetes_insipidus_and_intrauterine_fetal_death_of_monochorionic_twins_ L2 - https://doi.org/10.1038/jp.2008.95 DB - PRIME DP - Unbound Medicine ER -