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High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease.

Abstract

SUMMARY

Vitamin K and D deficiency and decreased bone mineral density (BMD) were highly prevalent in patients with inflammatory bowel disease (IBD), especially Crohn's disease (CD). Dietary intakes of these vitamins, however, were above the Japanese adequate intakes in IBD patients, suggesting that malabsorption is the basis for hypovitaminosis K and D and decreased BMD.

INTRODUCTION

We have studied the possible involvement of vitamin K and D deficiency in the pathogenesis of decreased BMD in IBD.

METHODS

Seventy patients with IBD were evaluated for their BMD; plasma levels of vitamin K; phylloquinone (PK), menaquinone-7 (MK-7), and 25OH-D; serum PTH, protein induced by vitamin K absence (PIVKA-II), and undercarboxylated osteocalcin (ucOC) levels; and their food intake.

RESULTS

Compared with ulcerative colitis (UC) patients, CD patients had significantly lower plasma vitamin K and 25OH-D concentrations; significantly higher serum levels of PTH, PIVKA-II, and ucOC; and significantly lower BMD scores at almost all measurement sites. More IBD patients were vitamin K deficient in bone than in liver. Multiple regression analyses revealed that low plasma concentrations of vitamin K and 25OH-D were independent risk factors for low BMD and that they were associated with the patients' fat intake, but not with their intake of these vitamins.

CONCLUSION

IBD patients have high prevalence of decreased BMD and vitamin K and D deficiency probably caused by malabsorption of these vitamins.

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  • Authors+Show Affiliations

    ,

    Department of Food and Nutrition, Kyoto Women's University, 35, Imakumano-kitahiyoshicho, Higashiyama, Kyoto 605-8501, Japan.

    , , , , , , , , ,

    Source

    MeSH

    Adult
    Bone Density
    Colitis, Ulcerative
    Crohn Disease
    Diet
    Female
    Fractures, Bone
    Humans
    Inflammatory Bowel Diseases
    Malabsorption Syndromes
    Male
    Nutritional Status
    Prevalence
    Regression Analysis
    Risk Factors
    Vitamin D Deficiency
    Vitamin K Deficiency

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18825300

    Citation

    Kuwabara, A, et al. "High Prevalence of Vitamin K and D Deficiency and Decreased BMD in Inflammatory Bowel Disease." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 20, no. 6, 2009, pp. 935-42.
    Kuwabara A, Tanaka K, Tsugawa N, et al. High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease. Osteoporos Int. 2009;20(6):935-42.
    Kuwabara, A., Tanaka, K., Tsugawa, N., Nakase, H., Tsuji, H., Shide, K., ... Kido, S. (2009). High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 20(6), pp. 935-42. doi:10.1007/s00198-008-0764-2.
    Kuwabara A, et al. High Prevalence of Vitamin K and D Deficiency and Decreased BMD in Inflammatory Bowel Disease. Osteoporos Int. 2009;20(6):935-42. PubMed PMID: 18825300.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease. AU - Kuwabara,A, AU - Tanaka,K, AU - Tsugawa,N, AU - Nakase,H, AU - Tsuji,H, AU - Shide,K, AU - Kamao,M, AU - Chiba,T, AU - Inagaki,N, AU - Okano,T, AU - Kido,S, Y1 - 2008/09/30/ PY - 2007/11/28/received PY - 2008/09/03/accepted PY - 2008/10/1/pubmed PY - 2010/5/21/medline PY - 2008/10/1/entrez SP - 935 EP - 42 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 20 IS - 6 N2 - SUMMARY: Vitamin K and D deficiency and decreased bone mineral density (BMD) were highly prevalent in patients with inflammatory bowel disease (IBD), especially Crohn's disease (CD). Dietary intakes of these vitamins, however, were above the Japanese adequate intakes in IBD patients, suggesting that malabsorption is the basis for hypovitaminosis K and D and decreased BMD. INTRODUCTION: We have studied the possible involvement of vitamin K and D deficiency in the pathogenesis of decreased BMD in IBD. METHODS: Seventy patients with IBD were evaluated for their BMD; plasma levels of vitamin K; phylloquinone (PK), menaquinone-7 (MK-7), and 25OH-D; serum PTH, protein induced by vitamin K absence (PIVKA-II), and undercarboxylated osteocalcin (ucOC) levels; and their food intake. RESULTS: Compared with ulcerative colitis (UC) patients, CD patients had significantly lower plasma vitamin K and 25OH-D concentrations; significantly higher serum levels of PTH, PIVKA-II, and ucOC; and significantly lower BMD scores at almost all measurement sites. More IBD patients were vitamin K deficient in bone than in liver. Multiple regression analyses revealed that low plasma concentrations of vitamin K and 25OH-D were independent risk factors for low BMD and that they were associated with the patients' fat intake, but not with their intake of these vitamins. CONCLUSION: IBD patients have high prevalence of decreased BMD and vitamin K and D deficiency probably caused by malabsorption of these vitamins. SN - 1433-2965 UR - https://www.unboundmedicine.com/medline/citation/18825300/High_prevalence_of_vitamin_K_and_D_deficiency_and_decreased_BMD_in_inflammatory_bowel_disease_ L2 - https://dx.doi.org/10.1007/s00198-008-0764-2 DB - PRIME DP - Unbound Medicine ER -