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Calpain inhibitory flavonoids isolated from Orostachys japonicus.
J Enzyme Inhib Med Chem. 2009 Jun; 24(3):676-9.JE

Abstract

The n-butanol (n-BuOH) fraction of Orostachys japonicus A. Berger (Crassulaceae) significantly inhibited calpain activity. Through the activity-guided isolation from the n-BuOH fraction, herbacetin 8-O-alpha-D-ribopyranoside (1), kaempferol (2), quercetin (3), afzelin (4), astragalin (5), isoquercetin (6) and quercitrin (7) were obtained. Their structures were determined by spectroscopic techniques. Among them, compound 3 and 5 had significant calpain inhibitory activities.

Authors+Show Affiliations

College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, 151-742, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18825531

Citation

Je Ma, Choong, et al. "Calpain Inhibitory Flavonoids Isolated From Orostachys Japonicus." Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 24, no. 3, 2009, pp. 676-9.
Je Ma C, Jung WJ, Lee KY, et al. Calpain inhibitory flavonoids isolated from Orostachys japonicus. J Enzyme Inhib Med Chem. 2009;24(3):676-9.
Je Ma, C., Jung, W. J., Lee, K. Y., Kim, Y. C., & Sung, S. H. (2009). Calpain inhibitory flavonoids isolated from Orostachys japonicus. Journal of Enzyme Inhibition and Medicinal Chemistry, 24(3), 676-9. https://doi.org/10.1080/14756360802328075
Je Ma C, et al. Calpain Inhibitory Flavonoids Isolated From Orostachys Japonicus. J Enzyme Inhib Med Chem. 2009;24(3):676-9. PubMed PMID: 18825531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calpain inhibitory flavonoids isolated from Orostachys japonicus. AU - Je Ma,Choong, AU - Jung,Won Joo, AU - Lee,Ki Yong, AU - Kim,Young Choong, AU - Sung,Sang Hyun, PY - 2008/10/1/pubmed PY - 2010/10/13/medline PY - 2008/10/1/entrez SP - 676 EP - 9 JF - Journal of enzyme inhibition and medicinal chemistry JO - J Enzyme Inhib Med Chem VL - 24 IS - 3 N2 - The n-butanol (n-BuOH) fraction of Orostachys japonicus A. Berger (Crassulaceae) significantly inhibited calpain activity. Through the activity-guided isolation from the n-BuOH fraction, herbacetin 8-O-alpha-D-ribopyranoside (1), kaempferol (2), quercetin (3), afzelin (4), astragalin (5), isoquercetin (6) and quercitrin (7) were obtained. Their structures were determined by spectroscopic techniques. Among them, compound 3 and 5 had significant calpain inhibitory activities. SN - 1475-6374 UR - https://www.unboundmedicine.com/medline/citation/18825531/Calpain_inhibitory_flavonoids_isolated_from_Orostachys_japonicus_ L2 - https://www.tandfonline.com/doi/full/10.1080/14756360802328075 DB - PRIME DP - Unbound Medicine ER -