Tags

Type your tag names separated by a space and hit enter

Risk of malignant neoplasms after liver transplantation: a population-based study.
Liver Transpl. 2008 Oct; 14(10):1428-36.LT

Abstract

Posttransplant malignancies have become a serious long-term complication after liver transplantation. Our aim was to compare the incidence of posttransplant cancers with national cancer incidence rates. The study included all Finnish liver transplant patients transplanted at the Helsinki University Central Hospital between 1982 and 2005. The cohort was linked with the nationwide Finnish Cancer Registry. Observed numbers of cancers were compared to site-specific expected numbers based on national cancer incidence rates stratified by age, sex, and calendar time. The standardized incidence ratios (SIRs) were calculated as observed-to-expected ratios. Thirty-nine posttransplant de novo cancers and 11 basal cell carcinomas were found in the cohort of 540 patients during 3222 person years of follow-up. The overall SIR was 2.59 (95% confidence interval 1.84-3.53). SIR was higher for males (SIR 4.16) than for females (SIR 1.74), higher among children (SIR 18.1) than among adults (SIR 5.77 for ages of 17-39 years and 2.27 for ages >/= 40 years), and more elevated in the immediate posttransplant period (SIR 3.71 at < 2 years) compared to later periods (SIR 2.46 at 2-10 years and 1.53 at >10 years). The most common cancer types were nonmelanoma skin cancer (SIR 38.5) and non-Hodgkin lymphoma (SIR 13.9). Non-Hodgkin lymphoma was associated with male gender, young age, and the immediate posttransplant period, whereas old age and antibody induction therapy increased skin cancer risk. In conclusion, cancer incidence is increased among liver transplant patients compared to the general population. This study points out the importance of cancer surveillance after liver transplantation.

Authors+Show Affiliations

Transplantation and Liver Surgery Clinic, Helsinki University Hospital, Helsinki, Finland. fredrik.aberg@helsinki.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18825704

Citation

Aberg, Fredrik, et al. "Risk of Malignant Neoplasms After Liver Transplantation: a Population-based Study." Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, vol. 14, no. 10, 2008, pp. 1428-36.
Aberg F, Pukkala E, Höckerstedt K, et al. Risk of malignant neoplasms after liver transplantation: a population-based study. Liver Transpl. 2008;14(10):1428-36.
Aberg, F., Pukkala, E., Höckerstedt, K., Sankila, R., & Isoniemi, H. (2008). Risk of malignant neoplasms after liver transplantation: a population-based study. Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 14(10), 1428-36. https://doi.org/10.1002/lt.21475
Aberg F, et al. Risk of Malignant Neoplasms After Liver Transplantation: a Population-based Study. Liver Transpl. 2008;14(10):1428-36. PubMed PMID: 18825704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of malignant neoplasms after liver transplantation: a population-based study. AU - Aberg,Fredrik, AU - Pukkala,Eero, AU - Höckerstedt,Krister, AU - Sankila,Risto, AU - Isoniemi,Helena, PY - 2008/10/1/pubmed PY - 2009/1/28/medline PY - 2008/10/1/entrez SP - 1428 EP - 36 JF - Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society JO - Liver Transpl VL - 14 IS - 10 N2 - Posttransplant malignancies have become a serious long-term complication after liver transplantation. Our aim was to compare the incidence of posttransplant cancers with national cancer incidence rates. The study included all Finnish liver transplant patients transplanted at the Helsinki University Central Hospital between 1982 and 2005. The cohort was linked with the nationwide Finnish Cancer Registry. Observed numbers of cancers were compared to site-specific expected numbers based on national cancer incidence rates stratified by age, sex, and calendar time. The standardized incidence ratios (SIRs) were calculated as observed-to-expected ratios. Thirty-nine posttransplant de novo cancers and 11 basal cell carcinomas were found in the cohort of 540 patients during 3222 person years of follow-up. The overall SIR was 2.59 (95% confidence interval 1.84-3.53). SIR was higher for males (SIR 4.16) than for females (SIR 1.74), higher among children (SIR 18.1) than among adults (SIR 5.77 for ages of 17-39 years and 2.27 for ages >/= 40 years), and more elevated in the immediate posttransplant period (SIR 3.71 at < 2 years) compared to later periods (SIR 2.46 at 2-10 years and 1.53 at >10 years). The most common cancer types were nonmelanoma skin cancer (SIR 38.5) and non-Hodgkin lymphoma (SIR 13.9). Non-Hodgkin lymphoma was associated with male gender, young age, and the immediate posttransplant period, whereas old age and antibody induction therapy increased skin cancer risk. In conclusion, cancer incidence is increased among liver transplant patients compared to the general population. This study points out the importance of cancer surveillance after liver transplantation. SN - 1527-6473 UR - https://www.unboundmedicine.com/medline/citation/18825704/Risk_of_malignant_neoplasms_after_liver_transplantation:_a_population_based_study_ L2 - https://doi.org/10.1002/lt.21475 DB - PRIME DP - Unbound Medicine ER -