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Cryptosporidium species and subtypes and clinical manifestations in children, Peru.
Emerg Infect Dis. 2008 Oct; 14(10):1567-74.EI

Abstract

To determine whether clinical manifestations are associated with genotypes or subtypes of Cryptosporidium spp., we studied a 4-year longitudinal birth cohort of 533 children in Peru. A total of 156 infection episodes were found in 109 children. Data from first infections showed that C. hominis was associated with diarrhea, nausea, vomiting, general malaise, and increased oocyst shedding intensity and duration. In contrast, C. parvum, C. meleagridis, C. canis, and C. felis were associated with diarrhea only. C. hominis subtype families were identified (Ia, Ib, Id, and Ie); all were associated with diarrhea. Ib was also associated with nausea, vomiting, and general malaise. All C. parvum specimens belonged to subtype family IIc. Analysis of risk factors did not show associations with specific Cryptosporidium spp. genotypes or subtypes. These findings strongly suggest that Cryptosporidium spp. and subtypes are linked to different clinical manifestations in children.

Authors+Show Affiliations

Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18826821

Citation

Cama, Vitaliano A., et al. "Cryptosporidium Species and Subtypes and Clinical Manifestations in Children, Peru." Emerging Infectious Diseases, vol. 14, no. 10, 2008, pp. 1567-74.
Cama VA, Bern C, Roberts J, et al. Cryptosporidium species and subtypes and clinical manifestations in children, Peru. Emerging Infect Dis. 2008;14(10):1567-74.
Cama, V. A., Bern, C., Roberts, J., Cabrera, L., Sterling, C. R., Ortega, Y., Gilman, R. H., & Xiao, L. (2008). Cryptosporidium species and subtypes and clinical manifestations in children, Peru. Emerging Infectious Diseases, 14(10), 1567-74. https://doi.org/10.3201/eid1410.071273
Cama VA, et al. Cryptosporidium Species and Subtypes and Clinical Manifestations in Children, Peru. Emerging Infect Dis. 2008;14(10):1567-74. PubMed PMID: 18826821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cryptosporidium species and subtypes and clinical manifestations in children, Peru. AU - Cama,Vitaliano A, AU - Bern,Caryn, AU - Roberts,Jacqueline, AU - Cabrera,Lilia, AU - Sterling,Charles R, AU - Ortega,Ynes, AU - Gilman,Robert H, AU - Xiao,Lihua, PY - 2008/10/2/pubmed PY - 2008/11/15/medline PY - 2008/10/2/entrez SP - 1567 EP - 74 JF - Emerging infectious diseases JO - Emerging Infect. Dis. VL - 14 IS - 10 N2 - To determine whether clinical manifestations are associated with genotypes or subtypes of Cryptosporidium spp., we studied a 4-year longitudinal birth cohort of 533 children in Peru. A total of 156 infection episodes were found in 109 children. Data from first infections showed that C. hominis was associated with diarrhea, nausea, vomiting, general malaise, and increased oocyst shedding intensity and duration. In contrast, C. parvum, C. meleagridis, C. canis, and C. felis were associated with diarrhea only. C. hominis subtype families were identified (Ia, Ib, Id, and Ie); all were associated with diarrhea. Ib was also associated with nausea, vomiting, and general malaise. All C. parvum specimens belonged to subtype family IIc. Analysis of risk factors did not show associations with specific Cryptosporidium spp. genotypes or subtypes. These findings strongly suggest that Cryptosporidium spp. and subtypes are linked to different clinical manifestations in children. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/18826821/full_citation L2 - https://dx.doi.org/10.3201/eid1410.071273 DB - PRIME DP - Unbound Medicine ER -