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Prevalent depressive symptoms as a risk factor for conversion to mild cognitive impairment in an elderly Italian cohort.
Am J Geriatr Psychiatry. 2008 Oct; 16(10):834-43.AJ

Abstract

OBJECTIVE

To examine the association between depressive symptoms and prevalent and incident mild cognitive impairment (MCI) in elderly individuals; to verify whether it is affected by MCI subtype.

DESIGN

Prospective, population-based, longitudinal cohort study.

SETTING

Adults >or=65 years resident in an Italian municipality.

PARTICIPANTS

Baseline data are for 595 subjects with no cognitive impairment (NCI) and 72 subjects with prevalent MCI. NCI subjects underwent a 4-year follow-up for incident MCI.

MEASUREMENTS

MCI was diagnosed according to international criteria and classified as with (m + MCI) or without memory impairment (m - MCI). Baseline depressive symptoms were measured using the 30-item Geriatric Depression Scale (GDS). Baseline use of antidepressants was also recorded.

RESULTS

Baseline depressive symptoms (GDS >or=10) were more frequent in prevalent MCI cases (44.4%) than in NCI participants (18.3%). The association was independent of MCI subtype, antidepressant use, and sociodemographic and vascular risk factors. In NCI subjects, baseline depressive symptoms were also associated with increased risk of MCI at follow-up, but only for subjects on antidepressant drugs at baseline (incident cases = 72.7%) compared with those without depressive symptoms and not on antidepressant therapy (incident cases = 24.0%). The association was independent of other confounders and stronger for m - MCI (incident cases = 45.4%) with respect to m + MCI (incident cases = 27.3%).

CONCLUSIONS

Depressive symptoms are highly prevalent among elderly MCI subjects and, in cognitively normal elderly individuals, are associated with an increased risk of developing MCI. The association is stronger for the MCI subtype without memory impairment.

Authors+Show Affiliations

Department of Internal Medicine, Ageing, and Nephrology, University Hospital S. Orsola-Malpighi, University of Bologna, Italy. giovanni.ravaglia@unibo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18827230

Citation

Ravaglia, Giovanni, et al. "Prevalent Depressive Symptoms as a Risk Factor for Conversion to Mild Cognitive Impairment in an Elderly Italian Cohort." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, vol. 16, no. 10, 2008, pp. 834-43.
Ravaglia G, Forti P, Lucicesare A, et al. Prevalent depressive symptoms as a risk factor for conversion to mild cognitive impairment in an elderly Italian cohort. Am J Geriatr Psychiatry. 2008;16(10):834-43.
Ravaglia, G., Forti, P., Lucicesare, A., Rietti, E., Pisacane, N., Mariani, E., & Dalmonte, E. (2008). Prevalent depressive symptoms as a risk factor for conversion to mild cognitive impairment in an elderly Italian cohort. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, 16(10), 834-43. https://doi.org/10.1097/JGP.0b013e318181f9b1
Ravaglia G, et al. Prevalent Depressive Symptoms as a Risk Factor for Conversion to Mild Cognitive Impairment in an Elderly Italian Cohort. Am J Geriatr Psychiatry. 2008;16(10):834-43. PubMed PMID: 18827230.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalent depressive symptoms as a risk factor for conversion to mild cognitive impairment in an elderly Italian cohort. AU - Ravaglia,Giovanni, AU - Forti,Paola, AU - Lucicesare,Anna, AU - Rietti,Elisa, AU - Pisacane,Nicoletta, AU - Mariani,Erminia, AU - Dalmonte,Edoardo, PY - 2008/10/2/pubmed PY - 2009/1/28/medline PY - 2008/10/2/entrez SP - 834 EP - 43 JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry JO - Am J Geriatr Psychiatry VL - 16 IS - 10 N2 - OBJECTIVE: To examine the association between depressive symptoms and prevalent and incident mild cognitive impairment (MCI) in elderly individuals; to verify whether it is affected by MCI subtype. DESIGN: Prospective, population-based, longitudinal cohort study. SETTING: Adults >or=65 years resident in an Italian municipality. PARTICIPANTS: Baseline data are for 595 subjects with no cognitive impairment (NCI) and 72 subjects with prevalent MCI. NCI subjects underwent a 4-year follow-up for incident MCI. MEASUREMENTS: MCI was diagnosed according to international criteria and classified as with (m + MCI) or without memory impairment (m - MCI). Baseline depressive symptoms were measured using the 30-item Geriatric Depression Scale (GDS). Baseline use of antidepressants was also recorded. RESULTS: Baseline depressive symptoms (GDS >or=10) were more frequent in prevalent MCI cases (44.4%) than in NCI participants (18.3%). The association was independent of MCI subtype, antidepressant use, and sociodemographic and vascular risk factors. In NCI subjects, baseline depressive symptoms were also associated with increased risk of MCI at follow-up, but only for subjects on antidepressant drugs at baseline (incident cases = 72.7%) compared with those without depressive symptoms and not on antidepressant therapy (incident cases = 24.0%). The association was independent of other confounders and stronger for m - MCI (incident cases = 45.4%) with respect to m + MCI (incident cases = 27.3%). CONCLUSIONS: Depressive symptoms are highly prevalent among elderly MCI subjects and, in cognitively normal elderly individuals, are associated with an increased risk of developing MCI. The association is stronger for the MCI subtype without memory impairment. SN - 1545-7214 UR - https://www.unboundmedicine.com/medline/citation/18827230/Prevalent_depressive_symptoms_as_a_risk_factor_for_conversion_to_mild_cognitive_impairment_in_an_elderly_Italian_cohort_ L2 - https://linkinghub.elsevier.com/retrieve/pii/16/10/834 DB - PRIME DP - Unbound Medicine ER -