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The risks of free copper in the body and the development of useful anticopper drugs.
Curr Opin Clin Nutr Metab Care 2008; 11(6):727-32CO

Abstract

PURPOSE OF REVIEW

To review the toxicity and risks of free copper in Wilson's disease, Alzheimer's disease, other disease of neurodegeneration, and cognitive loss in the general population. We will also review the anticopper drugs and how lowering free copper levels with an anticopper drug inhibits fibrosis, inflammation, and autoimmunity.

RECENT FINDINGS

Some exciting recent work indicates that free copper levels are increased in Alzheimer's disease, and copper may be involved in disease pathogenesis, opening the way to possible therapy of Alzheimer's disease with anticopper drugs. Copper may also be involved in other diseases of neurodegeneration. A very exciting recent study indicts high intake of copper, mostly from copper supplements, in conjunction with a high-fat diet in more rapid cognitive decline in the general population. Other data indicate that even low levels of copper in drinking water, perhaps similar to copper supplements, bypasses the liver, enters the circulation, increases the blood-brain penetration of copper, and may cause damage.

SUMMARY

Some of the implications are that Alzheimer's disease and other diseases of neurodegeneration and fibrotic, inflammatory, and autoimmune diseases may be treatable by lowering the availability of free copper. People in the general population may wish to take steps to lower their free copper levels and, in particular, to abstain from taking copper supplements and ingesting significant amounts of copper in drinking water.

Authors+Show Affiliations

Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109-5720, USA. brewergj@umich.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18827576

Citation

Brewer, George J.. "The Risks of Free Copper in the Body and the Development of Useful Anticopper Drugs." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 11, no. 6, 2008, pp. 727-32.
Brewer GJ. The risks of free copper in the body and the development of useful anticopper drugs. Curr Opin Clin Nutr Metab Care. 2008;11(6):727-32.
Brewer, G. J. (2008). The risks of free copper in the body and the development of useful anticopper drugs. Current Opinion in Clinical Nutrition and Metabolic Care, 11(6), pp. 727-32. doi:10.1097/MCO.0b013e328314b678.
Brewer GJ. The Risks of Free Copper in the Body and the Development of Useful Anticopper Drugs. Curr Opin Clin Nutr Metab Care. 2008;11(6):727-32. PubMed PMID: 18827576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The risks of free copper in the body and the development of useful anticopper drugs. A1 - Brewer,George J, PY - 2008/10/2/pubmed PY - 2009/1/30/medline PY - 2008/10/2/entrez SP - 727 EP - 32 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 11 IS - 6 N2 - PURPOSE OF REVIEW: To review the toxicity and risks of free copper in Wilson's disease, Alzheimer's disease, other disease of neurodegeneration, and cognitive loss in the general population. We will also review the anticopper drugs and how lowering free copper levels with an anticopper drug inhibits fibrosis, inflammation, and autoimmunity. RECENT FINDINGS: Some exciting recent work indicates that free copper levels are increased in Alzheimer's disease, and copper may be involved in disease pathogenesis, opening the way to possible therapy of Alzheimer's disease with anticopper drugs. Copper may also be involved in other diseases of neurodegeneration. A very exciting recent study indicts high intake of copper, mostly from copper supplements, in conjunction with a high-fat diet in more rapid cognitive decline in the general population. Other data indicate that even low levels of copper in drinking water, perhaps similar to copper supplements, bypasses the liver, enters the circulation, increases the blood-brain penetration of copper, and may cause damage. SUMMARY: Some of the implications are that Alzheimer's disease and other diseases of neurodegeneration and fibrotic, inflammatory, and autoimmune diseases may be treatable by lowering the availability of free copper. People in the general population may wish to take steps to lower their free copper levels and, in particular, to abstain from taking copper supplements and ingesting significant amounts of copper in drinking water. SN - 1363-1950 UR - https://www.unboundmedicine.com/medline/citation/18827576/The_risks_of_free_copper_in_the_body_and_the_development_of_useful_anticopper_drugs_ L2 - http://Insights.ovid.com/pubmed?pmid=18827576 DB - PRIME DP - Unbound Medicine ER -