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Regional gray matter volume deficits in adolescents with first-episode psychosis.
J Am Acad Child Adolesc Psychiatry 2008; 47(11):1311-20JA

Abstract

OBJECTIVE

The current study combined baseline voxel-based morphometry and 1-year clinical follow-up assessments to examine whether and where regional gray matter (GM) volumes differed between a control group and diagnostic subgroups of early-onset first-episode psychosis (FEP).

METHOD

Magnetic resonance imaging brain scans were obtained from 70 patients with early-onset FEP, and 51 non-FEP controls. Early-onset FEP was defined as age younger than 18 years and a duration of positive symptoms of less than 6 months. The age range of the sample was 7 to 18 years. After a 1-year follow-up, patients were stratified into three subgroups: schizophrenia (n = 25), bipolar I disorder (n = 20), and other psychoses (n = 25). Regional GM volumes of each patient subgroup were compared with those of the control group.

RESULTS

A follow-up diagnosis of schizophrenia was associated with GM volume deficits in the left medial and left middle frontal gyrus; bipolar I disorder was related to a GM volume deficit in the left medial frontal gyrus; and not having a follow-up diagnosis of schizophrenia or bipolar disorder was associated with smaller bilateral GM volumes in the insula and right middle occipital gyrus.

CONCLUSIONS

Left medial frontal GM volume deficits were common in the groups with schizophrenia and bipolar I disorder, which may point to shared underlying pathological findings.

Authors+Show Affiliations

Laboratorio de Imagen Medica, Experimental Medicine and Surgery, Hospital Universitario Gregorio Marañon, Madrid, Spain. jjanssen@mce.hggm.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18827723

Citation

Janssen, Joost, et al. "Regional Gray Matter Volume Deficits in Adolescents With First-episode Psychosis." Journal of the American Academy of Child and Adolescent Psychiatry, vol. 47, no. 11, 2008, pp. 1311-20.
Janssen J, Reig S, Parellada M, et al. Regional gray matter volume deficits in adolescents with first-episode psychosis. J Am Acad Child Adolesc Psychiatry. 2008;47(11):1311-20.
Janssen, J., Reig, S., Parellada, M., Moreno, D., Graell, M., Fraguas, D., ... Arango, C. (2008). Regional gray matter volume deficits in adolescents with first-episode psychosis. Journal of the American Academy of Child and Adolescent Psychiatry, 47(11), pp. 1311-20. doi:10.1097/CHI.0b013e318184ff48.
Janssen J, et al. Regional Gray Matter Volume Deficits in Adolescents With First-episode Psychosis. J Am Acad Child Adolesc Psychiatry. 2008;47(11):1311-20. PubMed PMID: 18827723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regional gray matter volume deficits in adolescents with first-episode psychosis. AU - Janssen,Joost, AU - Reig,Santiago, AU - Parellada,Mara, AU - Moreno,Dolores, AU - Graell,Montserrat, AU - Fraguas,David, AU - Zabala,Arantzazu, AU - Garcia Vazquez,Veronica, AU - Desco,Manuel, AU - Arango,Celso, PY - 2008/10/2/pubmed PY - 2009/3/6/medline PY - 2008/10/2/entrez SP - 1311 EP - 20 JF - Journal of the American Academy of Child and Adolescent Psychiatry JO - J Am Acad Child Adolesc Psychiatry VL - 47 IS - 11 N2 - OBJECTIVE: The current study combined baseline voxel-based morphometry and 1-year clinical follow-up assessments to examine whether and where regional gray matter (GM) volumes differed between a control group and diagnostic subgroups of early-onset first-episode psychosis (FEP). METHOD: Magnetic resonance imaging brain scans were obtained from 70 patients with early-onset FEP, and 51 non-FEP controls. Early-onset FEP was defined as age younger than 18 years and a duration of positive symptoms of less than 6 months. The age range of the sample was 7 to 18 years. After a 1-year follow-up, patients were stratified into three subgroups: schizophrenia (n = 25), bipolar I disorder (n = 20), and other psychoses (n = 25). Regional GM volumes of each patient subgroup were compared with those of the control group. RESULTS: A follow-up diagnosis of schizophrenia was associated with GM volume deficits in the left medial and left middle frontal gyrus; bipolar I disorder was related to a GM volume deficit in the left medial frontal gyrus; and not having a follow-up diagnosis of schizophrenia or bipolar disorder was associated with smaller bilateral GM volumes in the insula and right middle occipital gyrus. CONCLUSIONS: Left medial frontal GM volume deficits were common in the groups with schizophrenia and bipolar I disorder, which may point to shared underlying pathological findings. SN - 1527-5418 UR - https://www.unboundmedicine.com/medline/citation/18827723/Regional_gray_matter_volume_deficits_in_adolescents_with_first_episode_psychosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-8567(08)60122-7 DB - PRIME DP - Unbound Medicine ER -