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Cerebral dysfunctions of emotion-cognition interactions in adolescent-onset schizophrenia.
J Am Acad Child Adolesc Psychiatry. 2008 Nov; 47(11):1299-310.JA

Abstract

OBJECTIVE

Schizophrenia is among the most severe of psychiatric disorders, leading to impairments of affective and cognitive abilities. These dysfunctions affect each other mutually. Adolescent-onset schizophrenia (AOS) constitutes a particularly severe form of the disorder. In this study, possible dysfunctions of the neural correlates underlying the interaction of negative emotion and working memory in AOS were investigated.

METHOD

During functional magnetic resonance imaging, 12 patients with AOS and 12 non-AOS adolescents performed a verbal n-back task. Intermittently, negative and neutral emotions were induced by olfactory stimulation. Group differences in working memory, emotion, and their interaction were evaluated.

RESULTS

In patients with AOS, lower performance sensitivity was observed, along with dorsolateral prefrontal, anterior cingulate, and inferior parietal hypoactivation during working memory demands. For negative versus neutral emotion induction, patients with AOS mainly showed increased brain activation compared with control subjects in widespread brain regions including the left orbitofrontal cortex and the medial frontal gyrus. Finally, during the interaction of emotion and cognition, altered patterns of activation in patients with AOS were found in the thalamocortical network, including the angular and the middle cingulate gyri extending to the precuneus. These activation differences were further decomposed by parameter estimates.

CONCLUSIONS

Our results provide new insights into the neural correlates underlying the mutual influence of affective and cognitive symptoms in AOS. During the n-back task, areas typically associated with working memory performance were found hypoactivated in patients relative to the control subjects, including the dorsolateral prefrontal and parietal cortex and the anterior cingulate. However, patients with AOS mainly demonstrated increased activation in key areas of emotion processing, such as the left orbitofrontal cortex and medial frontal areas, during negative emotion induction. A dysfunctional thalamocortical network during the interaction mainly included regions involved in the integration of converging information--either on the subcortical (thalamus) or on a higher-order cortical level (comprising the angular gyrus). These findings point to dysfunctional emotion-cognition interactions in AOS, which may explain its poor prognosis.

Authors+Show Affiliations

Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany. kpauly@ukaachen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18827725

Citation

Pauly, Katharina, et al. "Cerebral Dysfunctions of Emotion-cognition Interactions in Adolescent-onset Schizophrenia." Journal of the American Academy of Child and Adolescent Psychiatry, vol. 47, no. 11, 2008, pp. 1299-310.
Pauly K, Seiferth NY, Kellermann T, et al. Cerebral dysfunctions of emotion-cognition interactions in adolescent-onset schizophrenia. J Am Acad Child Adolesc Psychiatry. 2008;47(11):1299-310.
Pauly, K., Seiferth, N. Y., Kellermann, T., Backes, V., Vloet, T. D., Shah, N. J., Schneider, F., Habel, U., & Kircher, T. T. (2008). Cerebral dysfunctions of emotion-cognition interactions in adolescent-onset schizophrenia. Journal of the American Academy of Child and Adolescent Psychiatry, 47(11), 1299-310. https://doi.org/10.1097/CHI.0b013e318184ff16
Pauly K, et al. Cerebral Dysfunctions of Emotion-cognition Interactions in Adolescent-onset Schizophrenia. J Am Acad Child Adolesc Psychiatry. 2008;47(11):1299-310. PubMed PMID: 18827725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebral dysfunctions of emotion-cognition interactions in adolescent-onset schizophrenia. AU - Pauly,Katharina, AU - Seiferth,Nina Y, AU - Kellermann,Thilo, AU - Backes,Volker, AU - Vloet,Timo D, AU - Shah,N Jon, AU - Schneider,Frank, AU - Habel,Ute, AU - Kircher,Tilo T, PY - 2008/10/2/pubmed PY - 2009/3/6/medline PY - 2008/10/2/entrez SP - 1299 EP - 310 JF - Journal of the American Academy of Child and Adolescent Psychiatry JO - J Am Acad Child Adolesc Psychiatry VL - 47 IS - 11 N2 - OBJECTIVE: Schizophrenia is among the most severe of psychiatric disorders, leading to impairments of affective and cognitive abilities. These dysfunctions affect each other mutually. Adolescent-onset schizophrenia (AOS) constitutes a particularly severe form of the disorder. In this study, possible dysfunctions of the neural correlates underlying the interaction of negative emotion and working memory in AOS were investigated. METHOD: During functional magnetic resonance imaging, 12 patients with AOS and 12 non-AOS adolescents performed a verbal n-back task. Intermittently, negative and neutral emotions were induced by olfactory stimulation. Group differences in working memory, emotion, and their interaction were evaluated. RESULTS: In patients with AOS, lower performance sensitivity was observed, along with dorsolateral prefrontal, anterior cingulate, and inferior parietal hypoactivation during working memory demands. For negative versus neutral emotion induction, patients with AOS mainly showed increased brain activation compared with control subjects in widespread brain regions including the left orbitofrontal cortex and the medial frontal gyrus. Finally, during the interaction of emotion and cognition, altered patterns of activation in patients with AOS were found in the thalamocortical network, including the angular and the middle cingulate gyri extending to the precuneus. These activation differences were further decomposed by parameter estimates. CONCLUSIONS: Our results provide new insights into the neural correlates underlying the mutual influence of affective and cognitive symptoms in AOS. During the n-back task, areas typically associated with working memory performance were found hypoactivated in patients relative to the control subjects, including the dorsolateral prefrontal and parietal cortex and the anterior cingulate. However, patients with AOS mainly demonstrated increased activation in key areas of emotion processing, such as the left orbitofrontal cortex and medial frontal areas, during negative emotion induction. A dysfunctional thalamocortical network during the interaction mainly included regions involved in the integration of converging information--either on the subcortical (thalamus) or on a higher-order cortical level (comprising the angular gyrus). These findings point to dysfunctional emotion-cognition interactions in AOS, which may explain its poor prognosis. SN - 1527-5418 UR - https://www.unboundmedicine.com/medline/citation/18827725/Cerebral_dysfunctions_of_emotion_cognition_interactions_in_adolescent_onset_schizophrenia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-8567(08)60121-5 DB - PRIME DP - Unbound Medicine ER -