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Disruption of bradycardia associated with discriminative conditioning in combat veterans with PTSD.
Neuropsychiatr Dis Treat. 2008 Jun; 4(3):635-46.ND

Abstract

The effects of combat-related posttraumatic stress disorder (PTSD) on heart rate (HR) responding associated with a discriminative delay eyeblink (EB) conditioning paradigm are reported. Combat PTSD+, Combat PTSD-, and Noncombat PTSD- veterans were assessed with psychometric self-report measures, and baseline heart rate variability (HRV) was measured before receiving a 72-trial session of discriminative EB classical conditioning. Two types (red or green light) of conditioned stimuli (CS) were used: one (CS+) predicted a tone, followed immediately by an aversive stimulus (corneal airpuff); the other (CS-) predicted a tone alone, not followed by the airpuff. The light signal was presented for 5 seconds, during which HR was measured. On all psychometric measures, the PTSD+ subgroup was significantly different from the PTSD- subgroups (Combat + Noncombat), and the PTSD- subgroups did not significantly differ from each other. A linear deceleration in HR to CS+ and CS- signals was found in the combined PTSD- subgroup and on CS- trials in the PTSD+ subgroup, but was not present on CS+ trials in the PTSD+ subgroup. Results are interpreted with respect to a behavioral stages model of conditioned bradycardia and in terms of neural substrates which are both critical to HR conditioning and known to be abnormal in PTSD.

Authors+Show Affiliations

Shirley L. Buchanan Neuroscience Laboratory, Dorn VA Medical Center, 6439 Garners Ferry Road, Columbia, SC, USA. Jay.Ginsberg@va.govNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18830395

Citation

Ginsberg, Jay P., et al. "Disruption of Bradycardia Associated With Discriminative Conditioning in Combat Veterans With PTSD." Neuropsychiatric Disease and Treatment, vol. 4, no. 3, 2008, pp. 635-46.
Ginsberg JP, Ayers E, Burriss L, et al. Disruption of bradycardia associated with discriminative conditioning in combat veterans with PTSD. Neuropsychiatr Dis Treat. 2008;4(3):635-46.
Ginsberg, J. P., Ayers, E., Burriss, L., & Powell, D. A. (2008). Disruption of bradycardia associated with discriminative conditioning in combat veterans with PTSD. Neuropsychiatric Disease and Treatment, 4(3), 635-46.
Ginsberg JP, et al. Disruption of Bradycardia Associated With Discriminative Conditioning in Combat Veterans With PTSD. Neuropsychiatr Dis Treat. 2008;4(3):635-46. PubMed PMID: 18830395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disruption of bradycardia associated with discriminative conditioning in combat veterans with PTSD. AU - Ginsberg,Jay P, AU - Ayers,Edwin, AU - Burriss,Louisa, AU - Powell,Donald A, PY - 2008/10/3/pubmed PY - 2008/10/3/medline PY - 2008/10/3/entrez KW - PTSD KW - bradycardia KW - classical conditioning KW - combat veterans SP - 635 EP - 46 JF - Neuropsychiatric disease and treatment JO - Neuropsychiatr Dis Treat VL - 4 IS - 3 N2 - The effects of combat-related posttraumatic stress disorder (PTSD) on heart rate (HR) responding associated with a discriminative delay eyeblink (EB) conditioning paradigm are reported. Combat PTSD+, Combat PTSD-, and Noncombat PTSD- veterans were assessed with psychometric self-report measures, and baseline heart rate variability (HRV) was measured before receiving a 72-trial session of discriminative EB classical conditioning. Two types (red or green light) of conditioned stimuli (CS) were used: one (CS+) predicted a tone, followed immediately by an aversive stimulus (corneal airpuff); the other (CS-) predicted a tone alone, not followed by the airpuff. The light signal was presented for 5 seconds, during which HR was measured. On all psychometric measures, the PTSD+ subgroup was significantly different from the PTSD- subgroups (Combat + Noncombat), and the PTSD- subgroups did not significantly differ from each other. A linear deceleration in HR to CS+ and CS- signals was found in the combined PTSD- subgroup and on CS- trials in the PTSD+ subgroup, but was not present on CS+ trials in the PTSD+ subgroup. Results are interpreted with respect to a behavioral stages model of conditioned bradycardia and in terms of neural substrates which are both critical to HR conditioning and known to be abnormal in PTSD. SN - 1176-6328 UR - https://www.unboundmedicine.com/medline/citation/18830395/Disruption_of_bradycardia_associated_with_discriminative_conditioning_in_combat_veterans_with_PTSD_ L2 - https://www.dovepress.com/articles.php?article_id=1873 DB - PRIME DP - Unbound Medicine ER -
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