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[Attention deficit/hyperactivity disorder: burden of the disease according to subtypes in recently diagnosed children].
Actas Esp Psiquiatr. 2008 Sep-Oct; 36(5):285-94.AE

Abstract

INTRODUCTION

Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with deterioration of several dimensions of quality of life (QoL) and with the development of comorbid psychiatric disorders. The objective of the present study is to evaluate the burden of illness of ADHD subtypes in untreated newly diagnosed children in Spain.

METHODS

We recruited 124 children (80 combined, 25 inattentive and 19 hyperactive-impulsive subtype) aged 6-12 years with untreated newly diagnosed Diagnostic and Statistical Manual of Mental Disorders, 4th edition DSM-IV) ADHD. We collected socio-demographic, clinical (Attention-Deficit/Hyperactivity Disorder Rating Scale ADHD-RS], Conner's Parent Rating Scale-Revised: Short Form [CPRS:R-S], Clinical Global Impression-Severity [CGI-S], Kiddie Schedule for Affective Disorders and Schizophrenia for School Aged Children-Present and Lifetime Version [K-SADS-PL], intelligence Quotient [IQ]), Quality of Life (QoL), Child Health Questionnaire-Parent Form 50 CHQ-PF50), academic performance and health care resources utilization data. We investigated the correlations between ADHD symptom severity and QoL, academic performance and time from onset of symptoms to diagnosis.

RESULTS

QoL of children with combined-type ADHD was rated as significantly worse in patients with predominance of hyperactivity/impulsivity for most of the domains. Inattentive-type children also had worse ratings than patients with hyperactivity/impulsivity predominance in most of the domains. The ADHD Index of Conner's Parent Rating Scale-Revised: Short Form (CPRS-R:S) was significantly lower in hyperactive/impulsive patients. We found no differences across subtypes in IQ, academic performance and health care resources utilization. Higher ADHD symptom severity was associated to poor QoL.

CONCLUSIONS

Combined and inattentive subtypes are associated with greater disorder severity, more comorbid psychiatric disorders, and worse QoL than the subtype with hyperactivity/impulsivity predominance.

Authors+Show Affiliations

Lilly Research Laboratories, Alcobendas (Madrid). escobarrodrigo@lilly.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

18830848

Citation

Escobar, R, et al. "[Attention Deficit/hyperactivity Disorder: Burden of the Disease According to Subtypes in Recently Diagnosed Children]." Actas Espanolas De Psiquiatria, vol. 36, no. 5, 2008, pp. 285-94.
Escobar R, Hervas A, Soutullo C, et al. [Attention deficit/hyperactivity disorder: burden of the disease according to subtypes in recently diagnosed children]. Actas Esp Psiquiatr. 2008;36(5):285-94.
Escobar, R., Hervas, A., Soutullo, C., Mardomingo, M. J., Uruñuela, A., & Gilaberte, I. (2008). [Attention deficit/hyperactivity disorder: burden of the disease according to subtypes in recently diagnosed children]. Actas Espanolas De Psiquiatria, 36(5), 285-94.
Escobar R, et al. [Attention Deficit/hyperactivity Disorder: Burden of the Disease According to Subtypes in Recently Diagnosed Children]. Actas Esp Psiquiatr. 2008 Sep-Oct;36(5):285-94. PubMed PMID: 18830848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Attention deficit/hyperactivity disorder: burden of the disease according to subtypes in recently diagnosed children]. AU - Escobar,R, AU - Hervas,A, AU - Soutullo,C, AU - Mardomingo,M J, AU - Uruñuela,A, AU - Gilaberte,I, PY - 2008/10/3/pubmed PY - 2009/3/6/medline PY - 2008/10/3/entrez SP - 285 EP - 94 JF - Actas espanolas de psiquiatria JO - Actas Esp Psiquiatr VL - 36 IS - 5 N2 - INTRODUCTION: Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with deterioration of several dimensions of quality of life (QoL) and with the development of comorbid psychiatric disorders. The objective of the present study is to evaluate the burden of illness of ADHD subtypes in untreated newly diagnosed children in Spain. METHODS: We recruited 124 children (80 combined, 25 inattentive and 19 hyperactive-impulsive subtype) aged 6-12 years with untreated newly diagnosed Diagnostic and Statistical Manual of Mental Disorders, 4th edition DSM-IV) ADHD. We collected socio-demographic, clinical (Attention-Deficit/Hyperactivity Disorder Rating Scale ADHD-RS], Conner's Parent Rating Scale-Revised: Short Form [CPRS:R-S], Clinical Global Impression-Severity [CGI-S], Kiddie Schedule for Affective Disorders and Schizophrenia for School Aged Children-Present and Lifetime Version [K-SADS-PL], intelligence Quotient [IQ]), Quality of Life (QoL), Child Health Questionnaire-Parent Form 50 CHQ-PF50), academic performance and health care resources utilization data. We investigated the correlations between ADHD symptom severity and QoL, academic performance and time from onset of symptoms to diagnosis. RESULTS: QoL of children with combined-type ADHD was rated as significantly worse in patients with predominance of hyperactivity/impulsivity for most of the domains. Inattentive-type children also had worse ratings than patients with hyperactivity/impulsivity predominance in most of the domains. The ADHD Index of Conner's Parent Rating Scale-Revised: Short Form (CPRS-R:S) was significantly lower in hyperactive/impulsive patients. We found no differences across subtypes in IQ, academic performance and health care resources utilization. Higher ADHD symptom severity was associated to poor QoL. CONCLUSIONS: Combined and inattentive subtypes are associated with greater disorder severity, more comorbid psychiatric disorders, and worse QoL than the subtype with hyperactivity/impulsivity predominance. SN - 1139-9287 UR - https://www.unboundmedicine.com/medline/citation/18830848/[Attention_deficit/hyperactivity_disorder:_burden_of_the_disease_according_to_subtypes_in_recently_diagnosed_children]_ L2 - http://www.diseaseinfosearch.org/result/659 DB - PRIME DP - Unbound Medicine ER -