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Antiobesity effects of wild ginseng (Panax ginseng C.A. Meyer) mediated by PPAR-gamma, GLUT4 and LPL in ob/ob mice.
Phytother Res. 2009 Feb; 23(2):220-5.PR

Abstract

The antiobesity effect of wild ginseng (WG; Panax ginseng C.A. Meyer) in male obese leptin-deficient (B6.V-Lepob, 'ob/ob') mice was evaluated. WG was administered orally to mice at doses of 100 mg/kg and 200 mg/kg daily for 4 weeks. The WG-treated ob/ob mice showed a loss of body weight and a decrease in blood glucose levels compared with control mice. WG regulated the mRNA expression level especially, it increased peroxisome proliferators-activated receptors-gamma (PPAR-gamma) and lipoprotein lipase (LPL) in adipose tissue, as well as glucose transporter 4 (GLUT4) and insulin receptor (IR) in the skeletal muscle and liver. Taken together, these results suggest that WG may play a vital role in the antiobesity effect in ob/ob mice; this has importance in insulin sensitivity. This may prove to be of clinical importance in improving the management of obesity and related metabolic syndromes.

Authors+Show Affiliations

College of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18830966

Citation

Mollah, Mohammad Lalmoddin, et al. "Antiobesity Effects of Wild Ginseng (Panax Ginseng C.A. Meyer) Mediated By PPAR-gamma, GLUT4 and LPL in Ob/ob Mice." Phytotherapy Research : PTR, vol. 23, no. 2, 2009, pp. 220-5.
Mollah ML, Kim GS, Moon HK, et al. Antiobesity effects of wild ginseng (Panax ginseng C.A. Meyer) mediated by PPAR-gamma, GLUT4 and LPL in ob/ob mice. Phytother Res. 2009;23(2):220-5.
Mollah, M. L., Kim, G. S., Moon, H. K., Chung, S. K., Cheon, Y. P., Kim, J. K., & Kim, K. S. (2009). Antiobesity effects of wild ginseng (Panax ginseng C.A. Meyer) mediated by PPAR-gamma, GLUT4 and LPL in ob/ob mice. Phytotherapy Research : PTR, 23(2), 220-5. https://doi.org/10.1002/ptr.2593
Mollah ML, et al. Antiobesity Effects of Wild Ginseng (Panax Ginseng C.A. Meyer) Mediated By PPAR-gamma, GLUT4 and LPL in Ob/ob Mice. Phytother Res. 2009;23(2):220-5. PubMed PMID: 18830966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiobesity effects of wild ginseng (Panax ginseng C.A. Meyer) mediated by PPAR-gamma, GLUT4 and LPL in ob/ob mice. AU - Mollah,Mohammad Lalmoddin, AU - Kim,Gi-Sang, AU - Moon,Hye-Kyung, AU - Chung,Shin-Kyo, AU - Cheon,Yong-Pil, AU - Kim,Jong-Kuk, AU - Kim,Kil-Soo, PY - 2008/10/3/pubmed PY - 2009/2/6/medline PY - 2008/10/3/entrez SP - 220 EP - 5 JF - Phytotherapy research : PTR JO - Phytother Res VL - 23 IS - 2 N2 - The antiobesity effect of wild ginseng (WG; Panax ginseng C.A. Meyer) in male obese leptin-deficient (B6.V-Lepob, 'ob/ob') mice was evaluated. WG was administered orally to mice at doses of 100 mg/kg and 200 mg/kg daily for 4 weeks. The WG-treated ob/ob mice showed a loss of body weight and a decrease in blood glucose levels compared with control mice. WG regulated the mRNA expression level especially, it increased peroxisome proliferators-activated receptors-gamma (PPAR-gamma) and lipoprotein lipase (LPL) in adipose tissue, as well as glucose transporter 4 (GLUT4) and insulin receptor (IR) in the skeletal muscle and liver. Taken together, these results suggest that WG may play a vital role in the antiobesity effect in ob/ob mice; this has importance in insulin sensitivity. This may prove to be of clinical importance in improving the management of obesity and related metabolic syndromes. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/18830966/Antiobesity_effects_of_wild_ginseng__Panax_ginseng_C_A__Meyer__mediated_by_PPAR_gamma_GLUT4_and_LPL_in_ob/ob_mice_ L2 - https://doi.org/10.1002/ptr.2593 DB - PRIME DP - Unbound Medicine ER -