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Nickel-catalyzed enantioselective alkylative coupling of alkynes and aldehydes: synthesis of chiral allylic alcohols with tetrasubstituted olefins.
J Am Chem Soc. 2008 Oct 29; 130(43):14052-3.JA

Abstract

A highly efficient nickel-catalyzed asymmetric alkylative coupling of alkynes, aldehydes, and dimethylzinc has been realized by using bulky spirobiindane phosphoramidite ligands, affording allylic alcohols with a tetrasubstituted olefin functionality in high yields, high regioselectivities, and excellent enantioselectivities.

Authors+Show Affiliations

State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18834121

Citation

Yang, Yun, et al. "Nickel-catalyzed Enantioselective Alkylative Coupling of Alkynes and Aldehydes: Synthesis of Chiral Allylic Alcohols With Tetrasubstituted Olefins." Journal of the American Chemical Society, vol. 130, no. 43, 2008, pp. 14052-3.
Yang Y, Zhu SF, Zhou CY, et al. Nickel-catalyzed enantioselective alkylative coupling of alkynes and aldehydes: synthesis of chiral allylic alcohols with tetrasubstituted olefins. J Am Chem Soc. 2008;130(43):14052-3.
Yang, Y., Zhu, S. F., Zhou, C. Y., & Zhou, Q. L. (2008). Nickel-catalyzed enantioselective alkylative coupling of alkynes and aldehydes: synthesis of chiral allylic alcohols with tetrasubstituted olefins. Journal of the American Chemical Society, 130(43), 14052-3. https://doi.org/10.1021/ja805296k
Yang Y, et al. Nickel-catalyzed Enantioselective Alkylative Coupling of Alkynes and Aldehydes: Synthesis of Chiral Allylic Alcohols With Tetrasubstituted Olefins. J Am Chem Soc. 2008 Oct 29;130(43):14052-3. PubMed PMID: 18834121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nickel-catalyzed enantioselective alkylative coupling of alkynes and aldehydes: synthesis of chiral allylic alcohols with tetrasubstituted olefins. AU - Yang,Yun, AU - Zhu,Shou-Fei, AU - Zhou,Chang-Yue, AU - Zhou,Qi-Lin, Y1 - 2008/10/04/ PY - 2008/10/7/pubmed PY - 2009/1/29/medline PY - 2008/10/7/entrez SP - 14052 EP - 3 JF - Journal of the American Chemical Society JO - J Am Chem Soc VL - 130 IS - 43 N2 - A highly efficient nickel-catalyzed asymmetric alkylative coupling of alkynes, aldehydes, and dimethylzinc has been realized by using bulky spirobiindane phosphoramidite ligands, affording allylic alcohols with a tetrasubstituted olefin functionality in high yields, high regioselectivities, and excellent enantioselectivities. SN - 1520-5126 UR - https://www.unboundmedicine.com/medline/citation/18834121/Nickel_catalyzed_enantioselective_alkylative_coupling_of_alkynes_and_aldehydes:_synthesis_of_chiral_allylic_alcohols_with_tetrasubstituted_olefins_ L2 - https://doi.org/10.1021/ja805296k DB - PRIME DP - Unbound Medicine ER -