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Restored photoreceptor outer segment and visual recovery after macular hole closure.
Am J Ophthalmol. 2009 Feb; 147(2):313-318.e1.AJ

Abstract

PURPOSE

To evaluate restoration of the photoreceptor outer segment and visual outcomes in closed macular holes.

DESIGN

Retrospective case series.

METHODS

We retrospectively observed the reparative process of macular holes in 28 eyes one, three, and six months postoperatively using spectral-domain optical coherence tomography. We evaluated the reflective line at the junction between the photoreceptor inner and outer segment (IS/OS) and the best-corrected visual acuity (BCVA).

RESULTS

The outer photoreceptor layer showed a foveal detachment, a disrupted IS/OS line, or both one month postoperatively. No eye had a continuous IS/OS line. These abnormalities were gradually restored at various levels. At six months, nine eyes had a normal outer photoreceptor layer, four eyes outer foveal defects with a continuous IS/OS line, 12 eyes a disrupted IS/OS line, and three eyes outer foveal defects with a disrupted IS/OS line. The mean BCVAs were significantly (P = .017) lower in groups with a disrupted IS/OS line compared to groups with a continuous IS/OS line with or without outer foveal defects.

CONCLUSIONS

Macular hole closure is attained by bridge formation (foveal detachment) and the IS/OS line heals in varying degrees. The visual outcomes were significantly better in eyes with a continuous IS/OS line than in those with a disrupted IS/OS line.

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Authors+Show Affiliations

Sano M
Department of Ophthalmology, Gunma University, School of Medicine, Maebashi, Japan.
Shimoda Y
No affiliation info available
Hashimoto H
No affiliation info available
Kishi S
No affiliation info available

MeSH

AgedColoring AgentsFemaleFollow-Up StudiesHumansIndocyanine GreenMaleMiddle AgedProne PositionRecovery of FunctionRetinal PerforationsRetinal Photoreceptor Cell Inner SegmentRetinal Photoreceptor Cell Outer SegmentRetrospective StudiesSulfur HexafluorideTomography, Optical CoherenceVisual AcuityVitrectomyWound Healing

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18835472

Citation

Sano, Morihiko, et al. "Restored Photoreceptor Outer Segment and Visual Recovery After Macular Hole Closure." American Journal of Ophthalmology, vol. 147, no. 2, 2009, pp. 313-318.e1.
Sano M, Shimoda Y, Hashimoto H, et al. Restored photoreceptor outer segment and visual recovery after macular hole closure. Am J Ophthalmol. 2009;147(2):313-318.e1.
Sano, M., Shimoda, Y., Hashimoto, H., & Kishi, S. (2009). Restored photoreceptor outer segment and visual recovery after macular hole closure. American Journal of Ophthalmology, 147(2), 313-e1. https://doi.org/10.1016/j.ajo.2008.08.002
Sano M, et al. Restored Photoreceptor Outer Segment and Visual Recovery After Macular Hole Closure. Am J Ophthalmol. 2009;147(2):313-318.e1. PubMed PMID: 18835472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Restored photoreceptor outer segment and visual recovery after macular hole closure. AU - Sano,Morihiko, AU - Shimoda,Yukitoshi, AU - Hashimoto,Hideaki, AU - Kishi,Shoji, Y1 - 2008/10/04/ PY - 2008/03/05/received PY - 2008/08/01/revised PY - 2008/08/02/accepted PY - 2008/10/7/pubmed PY - 2009/2/14/medline PY - 2008/10/7/entrez SP - 313 EP - 318.e1 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 147 IS - 2 N2 - PURPOSE: To evaluate restoration of the photoreceptor outer segment and visual outcomes in closed macular holes. DESIGN: Retrospective case series. METHODS: We retrospectively observed the reparative process of macular holes in 28 eyes one, three, and six months postoperatively using spectral-domain optical coherence tomography. We evaluated the reflective line at the junction between the photoreceptor inner and outer segment (IS/OS) and the best-corrected visual acuity (BCVA). RESULTS: The outer photoreceptor layer showed a foveal detachment, a disrupted IS/OS line, or both one month postoperatively. No eye had a continuous IS/OS line. These abnormalities were gradually restored at various levels. At six months, nine eyes had a normal outer photoreceptor layer, four eyes outer foveal defects with a continuous IS/OS line, 12 eyes a disrupted IS/OS line, and three eyes outer foveal defects with a disrupted IS/OS line. The mean BCVAs were significantly (P = .017) lower in groups with a disrupted IS/OS line compared to groups with a continuous IS/OS line with or without outer foveal defects. CONCLUSIONS: Macular hole closure is attained by bridge formation (foveal detachment) and the IS/OS line heals in varying degrees. The visual outcomes were significantly better in eyes with a continuous IS/OS line than in those with a disrupted IS/OS line. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/18835472/Restored_photoreceptor_outer_segment_and_visual_recovery_after_macular_hole_closure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(08)00618-1 DB - PRIME DP - Unbound Medicine ER -