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Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Haematologica 2008; 93(11):1666-77H

Abstract

BACKGROUND

The incidences of non-Hodgkin's lymphoma and multiple myeloma are increasing steadily. It has been hypothesized that this may be due, in part, to the parallel rising prevalence of obesity. It is biologically plausible that anthropometric characteristics can infuence the risk of non-Hodgkin's lymphoma and multiple myeloma.

DESIGN AND METHODS

In the context of the European Prospective Investigation into Cancer and Nutrition (EPIC), anthropometric characteristics were assessed in 371,983 cancer-free individuals at baseline. During the 8.5 years of follow-up, 1,219 histologically confirmed incident cases of non-Hodgkin's lymphoma and multiple myeloma occurred in 609 men and 610 women. Gender-specific proportional hazards models were used to estimate relative risks and 95% confidence intervals (95% CI) of development of non-Hodgkin's lymphoma and multiple myeloma in relation to the anthropometric characteristics.

RESULTS

Height was associated with overall non-Hodgkin's lymphoma and multiple myeloma in women (RR 1.50, 95% CI 1.14-1.98) for highest versus lowest quartile; p-trend < 0.01) but not in men. Neither obesity (weight and body mass index) nor abdominal fat (waist-to-hip ratio, waist or hip circumference) measures were positively associated with overall non-Hodgkin's lymphoma and multiple myeloma. Relative risks for highest versus lowest body mass index quartile were 1.09 (95% CI 0.85-1.38) and 0.92 (95% CI 0.71-1.19) for men and women, respectively. Women in the upper body mass index quartile were at greater risk of diffuse large B-cell lymphoma (RR 2.18, 95% CI 1.05-4.53) and taller women had an elevated risk of follicular lymphoma (RR 1.25, 95% CI 0.59-2.62). Among men, height and body mass index were non-significantly, positively related to follicular lymphoma. Multiple myeloma risk alone was elevated for taller women (RR 2.34, 95% CI 1.29-4.21) and heavier men (RR 1.77, 95% CI 1.02-3.05).

CONCLUSIONS

The EPIC analyses support an association between height and overall non-Hodgkin's lymphoma and multiple myeloma among women and suggest heterogeneous subtype associations. This is one of the first prospective studies focusing on central adiposity and non-Hodgkin's lymphoma subtypes.

Authors+Show Affiliations

Department of Epidemiology and Public Health, Imperial College London, Room 151, St Mary's Campus, Norfolk Place W2 1PG, London, UK. p.vineis@imperial.ac.uk.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18835833

Citation

Britton, Julie A., et al. "Anthropometric Characteristics and non-Hodgkin's Lymphoma and Multiple Myeloma Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC)." Haematologica, vol. 93, no. 11, 2008, pp. 1666-77.
Britton JA, Khan AE, Rohrmann S, et al. Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Haematologica. 2008;93(11):1666-77.
Britton, J. A., Khan, A. E., Rohrmann, S., Becker, N., Linseisen, J., Nieters, A., ... Riboli, E. (2008). Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Haematologica, 93(11), pp. 1666-77. doi:10.3324/haematol.13078.
Britton JA, et al. Anthropometric Characteristics and non-Hodgkin's Lymphoma and Multiple Myeloma Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC). Haematologica. 2008;93(11):1666-77. PubMed PMID: 18835833.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). AU - Britton,Julie A, AU - Khan,Aneire E, AU - Rohrmann,Sabine, AU - Becker,Nikolaus, AU - Linseisen,Jakob, AU - Nieters,Alexandra, AU - Kaaks,Rudolf, AU - Tjønneland,Anne, AU - Halkjaer,Jytte, AU - Severinsen,Marianne Tang, AU - Overvad,Kim, AU - Pischon,Tobias, AU - Boeing,Heiner, AU - Trichopoulou,Antonia, AU - Kalapothaki,Victoria, AU - Trichopoulos,Dimitrios, AU - Mattiello,Amalia, AU - Tagliabue,Giovanna, AU - Sacerdote,Carlotta, AU - Peeters,Petra H M, AU - Bueno-de-Mesquita,H Bas, AU - Ardanaz,Eva, AU - Navarro,Carmen, AU - Jakszyn,Paula, AU - Altzibar,Jone M, AU - Hallmans,Göran, AU - Malmer,Beatrice, AU - Berglund,Göran, AU - Manjer,Jonas, AU - Allen,Naomi, AU - Key,Timothy, AU - Bingham,Sheila, AU - Besson,Hervé, AU - Ferrari,Pietro, AU - Jenab,Mazda, AU - Boffetta,Paolo, AU - Vineis,Paolo, AU - Riboli,Elio, Y1 - 2008/10/02/ PY - 2008/10/7/pubmed PY - 2008/11/19/medline PY - 2008/10/7/entrez SP - 1666 EP - 77 JF - Haematologica JO - Haematologica VL - 93 IS - 11 N2 - BACKGROUND: The incidences of non-Hodgkin's lymphoma and multiple myeloma are increasing steadily. It has been hypothesized that this may be due, in part, to the parallel rising prevalence of obesity. It is biologically plausible that anthropometric characteristics can infuence the risk of non-Hodgkin's lymphoma and multiple myeloma. DESIGN AND METHODS: In the context of the European Prospective Investigation into Cancer and Nutrition (EPIC), anthropometric characteristics were assessed in 371,983 cancer-free individuals at baseline. During the 8.5 years of follow-up, 1,219 histologically confirmed incident cases of non-Hodgkin's lymphoma and multiple myeloma occurred in 609 men and 610 women. Gender-specific proportional hazards models were used to estimate relative risks and 95% confidence intervals (95% CI) of development of non-Hodgkin's lymphoma and multiple myeloma in relation to the anthropometric characteristics. RESULTS: Height was associated with overall non-Hodgkin's lymphoma and multiple myeloma in women (RR 1.50, 95% CI 1.14-1.98) for highest versus lowest quartile; p-trend < 0.01) but not in men. Neither obesity (weight and body mass index) nor abdominal fat (waist-to-hip ratio, waist or hip circumference) measures were positively associated with overall non-Hodgkin's lymphoma and multiple myeloma. Relative risks for highest versus lowest body mass index quartile were 1.09 (95% CI 0.85-1.38) and 0.92 (95% CI 0.71-1.19) for men and women, respectively. Women in the upper body mass index quartile were at greater risk of diffuse large B-cell lymphoma (RR 2.18, 95% CI 1.05-4.53) and taller women had an elevated risk of follicular lymphoma (RR 1.25, 95% CI 0.59-2.62). Among men, height and body mass index were non-significantly, positively related to follicular lymphoma. Multiple myeloma risk alone was elevated for taller women (RR 2.34, 95% CI 1.29-4.21) and heavier men (RR 1.77, 95% CI 1.02-3.05). CONCLUSIONS: The EPIC analyses support an association between height and overall non-Hodgkin's lymphoma and multiple myeloma among women and suggest heterogeneous subtype associations. This is one of the first prospective studies focusing on central adiposity and non-Hodgkin's lymphoma subtypes. SN - 1592-8721 UR - https://www.unboundmedicine.com/medline/citation/18835833/Anthropometric_characteristics_and_non_Hodgkin's_lymphoma_and_multiple_myeloma_risk_in_the_European_Prospective_Investigation_into_Cancer_and_Nutrition__EPIC__ L2 - http://www.haematologica.org/cgi/pmidlookup?view=long&amp;pmid=18835833 DB - PRIME DP - Unbound Medicine ER -