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Influence of temperature on the radiochemical purity of 99mTc-colloidal rhenium sulfide for use in sentinel node localization.
Nucl Med Commun. 2008 Nov; 29(11):1015-20.NM

Abstract

BACKGROUND

Some preparations of 99mTc-colloidal rhenium sulfide (Nanocis) contain excess free pertechnetate (99mTcO4) impurity (>5%).

OBJECTIVES

To improve the radiochemical purity of Nanocis preparations and the quality of preoperative lymphoscintigraphy in sentinel node localization of breast cancer patients, we investigated the effects of temperature on the presence of free 99mTcO4 and nanocolloid size modification.

METHODS

A Nanocis kit was reconstituted with sodium pertechnetate (650-850 MBq) in a final volume of 3.5 ml and heated for 30 min at 100, 115, or 130 degrees C. The radiochemical purity was determined by paper chromatography, in triplicate. The particle size was evaluated by membrane filtration through a 200-nm and 100-nm filter. The preoperative lymphoscintigraphy images were acquired about 2 h after tracer administration.

RESULTS

Significantly higher radiochemical purity values were observed with 28 Nanocis preparations heated at 130 degrees C (median: 99.8%, min-max: 97.0-99.9%) compared with values from 37 Nanocis preparations heated at 100 degrees C (median: 96.3%, min-max: 85.2-99.5%) or 26 Nanocis preparations heated at 115 degrees C (median: 95.1%, min-max: 85.7-99.8%). The interbatch variations of the radiochemical purity were reduced at 130 degrees C. A high temperature level (130 degrees C) did not modify the particle size. In lymphoscintigraphy, free 99mTcO4 uptake by the thyroid or stomach, which was sometimes observed with a Nanocis preparation heated at 100 or 115 degrees C, was never visualized with a Nanocis preparation heated at 130 degrees C.

CONCLUSION

These results indicate that increasing temperature from 100 to 130 degrees C can be used in routine clinical practice to improve the radiochemical purity of the Nanocis preparation.

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Authors+Show Affiliations

Bensimhon L
Department of Nuclear Medicine, University Hospital, Poitiers, France.
Métayé T
No affiliation info available
Guilhot J
No affiliation info available
Perdrisot R
No affiliation info available

MeSH

Breast NeoplasmsChloridesChromatography, PaperFemaleFiltrationHumansLymph NodesLymphatic MetastasisParticle SizeRadionuclide ImagingRadiopharmaceuticalsRheniumSodium Pertechnetate Tc 99mSulfidesTechnetium Tc 99m Sulfur ColloidTemperature

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18836382

Citation

Bensimhon, Lyza, et al. "Influence of Temperature On the Radiochemical Purity of 99mTc-colloidal Rhenium Sulfide for Use in Sentinel Node Localization." Nuclear Medicine Communications, vol. 29, no. 11, 2008, pp. 1015-20.
Bensimhon L, Métayé T, Guilhot J, et al. Influence of temperature on the radiochemical purity of 99mTc-colloidal rhenium sulfide for use in sentinel node localization. Nucl Med Commun. 2008;29(11):1015-20.
Bensimhon, L., Métayé, T., Guilhot, J., & Perdrisot, R. (2008). Influence of temperature on the radiochemical purity of 99mTc-colloidal rhenium sulfide for use in sentinel node localization. Nuclear Medicine Communications, 29(11), 1015-20. https://doi.org/10.1097/MNM.0b013e32830ebd13
Bensimhon L, et al. Influence of Temperature On the Radiochemical Purity of 99mTc-colloidal Rhenium Sulfide for Use in Sentinel Node Localization. Nucl Med Commun. 2008;29(11):1015-20. PubMed PMID: 18836382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of temperature on the radiochemical purity of 99mTc-colloidal rhenium sulfide for use in sentinel node localization. AU - Bensimhon,Lyza, AU - Métayé,Thierry, AU - Guilhot,Joëlle, AU - Perdrisot,Rémy, PY - 2008/10/7/pubmed PY - 2009/2/25/medline PY - 2008/10/7/entrez SP - 1015 EP - 20 JF - Nuclear medicine communications JO - Nucl Med Commun VL - 29 IS - 11 N2 - BACKGROUND: Some preparations of 99mTc-colloidal rhenium sulfide (Nanocis) contain excess free pertechnetate (99mTcO4) impurity (>5%). OBJECTIVES: To improve the radiochemical purity of Nanocis preparations and the quality of preoperative lymphoscintigraphy in sentinel node localization of breast cancer patients, we investigated the effects of temperature on the presence of free 99mTcO4 and nanocolloid size modification. METHODS: A Nanocis kit was reconstituted with sodium pertechnetate (650-850 MBq) in a final volume of 3.5 ml and heated for 30 min at 100, 115, or 130 degrees C. The radiochemical purity was determined by paper chromatography, in triplicate. The particle size was evaluated by membrane filtration through a 200-nm and 100-nm filter. The preoperative lymphoscintigraphy images were acquired about 2 h after tracer administration. RESULTS: Significantly higher radiochemical purity values were observed with 28 Nanocis preparations heated at 130 degrees C (median: 99.8%, min-max: 97.0-99.9%) compared with values from 37 Nanocis preparations heated at 100 degrees C (median: 96.3%, min-max: 85.2-99.5%) or 26 Nanocis preparations heated at 115 degrees C (median: 95.1%, min-max: 85.7-99.8%). The interbatch variations of the radiochemical purity were reduced at 130 degrees C. A high temperature level (130 degrees C) did not modify the particle size. In lymphoscintigraphy, free 99mTcO4 uptake by the thyroid or stomach, which was sometimes observed with a Nanocis preparation heated at 100 or 115 degrees C, was never visualized with a Nanocis preparation heated at 130 degrees C. CONCLUSION: These results indicate that increasing temperature from 100 to 130 degrees C can be used in routine clinical practice to improve the radiochemical purity of the Nanocis preparation. SN - 0143-3636 UR - https://www.unboundmedicine.com/medline/citation/18836382/Influence_of_temperature_on_the_radiochemical_purity_of_99mTc_colloidal_rhenium_sulfide_for_use_in_sentinel_node_localization_ L2 - https://doi.org/10.1097/MNM.0b013e32830ebd13 DB - PRIME DP - Unbound Medicine ER -