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Therapy directed against thymic stromal lymphopoietin.
Drug News Perspect. 2008 Jul-Aug; 21(6):312-6.DN

Abstract

Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine and has been shown to be one of the factors released by epithelial cells following allergen contact with an important role instructing dendritic cells (DCs) to induce a T-helper type 2 (Th2) response. These TSLP-DC stimulate CD4(+) T cells to induce a proallergic cytokine profile, suggesting TSLP plays a crucial role in the initiation of the allergic cascade. Recently, evidence has also accumulated that TSLP could play a role in enhancement of the effector stages of the allergic response, with TSLP in synergy with IL-1 and tumor necrosis factor (TNF)-alpha shown to amplify cytokine secretion from mast cells. Also, the clinical relevance of TSLP has been demonstrated by both high levels of TSLP in skin biopsies from lesional atopic dermatitis patients and also increased expression of TSLP in asthmatic airway epithelial cells which correlated with reduced lung function. These studies suggest a critical role for TSLP as a driving factor in the emerging concept of tissue-specific control of immunity with TSLP secretion at the epithelial-DC interface acting as an initial factor in the proallergic cascade.

Authors+Show Affiliations

Respiratory Disease Area, Novartis Institute of Biomedical Research, Horsham, UK. matt.edwards@novartis.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18836588

Citation

Edwards, Matthew J.. "Therapy Directed Against Thymic Stromal Lymphopoietin." Drug News & Perspectives, vol. 21, no. 6, 2008, pp. 312-6.
Edwards MJ. Therapy directed against thymic stromal lymphopoietin. Drug News Perspect. 2008;21(6):312-6.
Edwards, M. J. (2008). Therapy directed against thymic stromal lymphopoietin. Drug News & Perspectives, 21(6), 312-6. https://doi.org/10.1358/dnp.2008.21.6.1246830
Edwards MJ. Therapy Directed Against Thymic Stromal Lymphopoietin. Drug News Perspect. 2008 Jul-Aug;21(6):312-6. PubMed PMID: 18836588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapy directed against thymic stromal lymphopoietin. A1 - Edwards,Matthew J, PY - 2008/10/7/pubmed PY - 2009/1/16/medline PY - 2008/10/7/entrez SP - 312 EP - 6 JF - Drug news & perspectives JO - Drug News Perspect. VL - 21 IS - 6 N2 - Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine and has been shown to be one of the factors released by epithelial cells following allergen contact with an important role instructing dendritic cells (DCs) to induce a T-helper type 2 (Th2) response. These TSLP-DC stimulate CD4(+) T cells to induce a proallergic cytokine profile, suggesting TSLP plays a crucial role in the initiation of the allergic cascade. Recently, evidence has also accumulated that TSLP could play a role in enhancement of the effector stages of the allergic response, with TSLP in synergy with IL-1 and tumor necrosis factor (TNF)-alpha shown to amplify cytokine secretion from mast cells. Also, the clinical relevance of TSLP has been demonstrated by both high levels of TSLP in skin biopsies from lesional atopic dermatitis patients and also increased expression of TSLP in asthmatic airway epithelial cells which correlated with reduced lung function. These studies suggest a critical role for TSLP as a driving factor in the emerging concept of tissue-specific control of immunity with TSLP secretion at the epithelial-DC interface acting as an initial factor in the proallergic cascade. SN - 0214-0934 UR - https://www.unboundmedicine.com/medline/citation/18836588/Therapy_directed_against_thymic_stromal_lymphopoietin_ L2 - http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summaryn_pr?p_JournalId=3&p_RefId=1246830 DB - PRIME DP - Unbound Medicine ER -