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Childhood and adolescent cancer survival in the US by race and ethnicity for the diagnostic period 1975-1999.
Cancer 2008; 113(9):2575-96C

Abstract

BACKGROUND

Survival trends provide a measure of improvement in detection and treatment over time. In the current study, updated childhood and adolescent cancer survival statistics are presented, overall and among demographic subgroups, including Hispanics, for whom to the authors' knowledge national rates have not been previously reported. These results extend those provided by the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program in their detail and interpretation.

METHODS

Survival trends of primary cancers in children and adolescents (ages birth to 19 years) were evaluated using SEER 9 data. Five-year and 10-year relative survival rates across 5-year (1975-1979, 1985-1989, and 1995-1999) and 10-year (1975-1984 and 1985-1994) cohorts were compared via Z-tests. Annual percent change (APC) in survival was computed via weighted least-squares regression. Rates in Hispanic children and adolescents were compared with those in non-Hispanic whites and blacks (SEER 13, 1995-1999).

RESULTS

Five-year survival rates increased significantly overall (1975-1979: 63% vs 1995-1999: 79%; P< .0001) and for nearly all histologic types examined; increases were greatest for ependymoma (+37%; P< .0001) and non-Hodgkin lymphoma (+34%; P< .0001). Hispanic children and adolescents had somewhat poorer 5-year rates than non-Hispanic whites overall (74% vs 81%; P< .0001) and for Ewing sarcoma, leukemia, central nervous system tumors, and melanoma. Ten-year rates also increased significantly overall (1975-1984: 61% vs 1985-1994: 72%; P< .0001) and for a majority of cancer types. The largest improvements were noted for acute lymphoblastic leukemia (+19%; P< .0001) and non-Hodgkin lymphoma (+19%; P< .0001).

CONCLUSIONS

Observed trends reinforce the need for resources devoted to advancing treatment modalities, reducing disparities among racial/ethnic groups and adolescents, and providing long-term care of survivors.

Authors+Show Affiliations

Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18837040

Citation

Linabery, Amy M., and Julie A. Ross. "Childhood and Adolescent Cancer Survival in the US By Race and Ethnicity for the Diagnostic Period 1975-1999." Cancer, vol. 113, no. 9, 2008, pp. 2575-96.
Linabery AM, Ross JA. Childhood and adolescent cancer survival in the US by race and ethnicity for the diagnostic period 1975-1999. Cancer. 2008;113(9):2575-96.
Linabery, A. M., & Ross, J. A. (2008). Childhood and adolescent cancer survival in the US by race and ethnicity for the diagnostic period 1975-1999. Cancer, 113(9), pp. 2575-96. doi:10.1002/cncr.23866.
Linabery AM, Ross JA. Childhood and Adolescent Cancer Survival in the US By Race and Ethnicity for the Diagnostic Period 1975-1999. Cancer. 2008 Nov 1;113(9):2575-96. PubMed PMID: 18837040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Childhood and adolescent cancer survival in the US by race and ethnicity for the diagnostic period 1975-1999. AU - Linabery,Amy M, AU - Ross,Julie A, PY - 2008/10/7/pubmed PY - 2008/12/17/medline PY - 2008/10/7/entrez SP - 2575 EP - 96 JF - Cancer JO - Cancer VL - 113 IS - 9 N2 - BACKGROUND: Survival trends provide a measure of improvement in detection and treatment over time. In the current study, updated childhood and adolescent cancer survival statistics are presented, overall and among demographic subgroups, including Hispanics, for whom to the authors' knowledge national rates have not been previously reported. These results extend those provided by the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program in their detail and interpretation. METHODS: Survival trends of primary cancers in children and adolescents (ages birth to 19 years) were evaluated using SEER 9 data. Five-year and 10-year relative survival rates across 5-year (1975-1979, 1985-1989, and 1995-1999) and 10-year (1975-1984 and 1985-1994) cohorts were compared via Z-tests. Annual percent change (APC) in survival was computed via weighted least-squares regression. Rates in Hispanic children and adolescents were compared with those in non-Hispanic whites and blacks (SEER 13, 1995-1999). RESULTS: Five-year survival rates increased significantly overall (1975-1979: 63% vs 1995-1999: 79%; P< .0001) and for nearly all histologic types examined; increases were greatest for ependymoma (+37%; P< .0001) and non-Hodgkin lymphoma (+34%; P< .0001). Hispanic children and adolescents had somewhat poorer 5-year rates than non-Hispanic whites overall (74% vs 81%; P< .0001) and for Ewing sarcoma, leukemia, central nervous system tumors, and melanoma. Ten-year rates also increased significantly overall (1975-1984: 61% vs 1985-1994: 72%; P< .0001) and for a majority of cancer types. The largest improvements were noted for acute lymphoblastic leukemia (+19%; P< .0001) and non-Hodgkin lymphoma (+19%; P< .0001). CONCLUSIONS: Observed trends reinforce the need for resources devoted to advancing treatment modalities, reducing disparities among racial/ethnic groups and adolescents, and providing long-term care of survivors. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/18837040/Childhood_and_adolescent_cancer_survival_in_the_US_by_race_and_ethnicity_for_the_diagnostic_period_1975_1999_ L2 - https://doi.org/10.1002/cncr.23866 DB - PRIME DP - Unbound Medicine ER -