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Autonomic neuropathy precedes cardiovascular dysfunction in rats with diabetes.
Eur J Clin Invest. 2008 Sep; 38(9):607-14.EJ

Abstract

BACKGROUND

Our team previously demonstrated arterial stiffening and cardiac hypertrophy in type 2 diabetic rats at 8 but not 4 weeks after being administered streptozotocin (STZ) and nicotinamide (NA). The present study focused on investigating the effects of type 2 diabetes on cardiac autonomic nerve function in the STZ- and NA-treated animals, using modern spectral estimation technique.

DESIGN

An autoregressive process was performed to each detrended signal of heart rate and systolic blood pressure measured in the 4- and 8-week STZ-NA rats with anaesthesia. The power of low-frequency and high-frequency oscillations was automatically quantified with each spectral peak by computing the residuals. The closed-loop baroreflex gain was estimated using the square root of the ratio between heart rate and systolic blood pressure powers in the low-frequency band.

RESULTS

Compared with the age-matched controls, both the 4- and 8-week STZ-NA diabetic rats had significantly decreased low-frequency oscillations of heart rate but not systolic blood pressure variability, showing a decline in baroreflex gain (0.451 +/- 0.060 and 0.484 +/- 0.056 vs. 1.196 +/- 0.064 ms mmHg(-1), P < 0.05). On the other hand, the low frequency-high frequency power ratio of the heart period was also diminished in the two diabetic groups, indicating a shift in sympatho-vagal balance of the heart control (0.472 +/- 0.109 and 0.504 +/- 0.090 vs. 1.857 +/- 0.336, P < 0.05).

CONCLUSIONS

The cardiac autonomic dysfunction in the absence of any significant changes in vascular dynamics, 4 but not 8 weeks after induction of type 2 diabetes, suggests that the diabetic autonomic neuropathy may precede arterial stiffening and cardiac hypertrophy in the STZ- and NA-treated rats.

Authors+Show Affiliations

Department of Automatic Control Engineering, Feng-Chia University, Taichung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18837735

Citation

Lin, Y-D, et al. "Autonomic Neuropathy Precedes Cardiovascular Dysfunction in Rats With Diabetes." European Journal of Clinical Investigation, vol. 38, no. 9, 2008, pp. 607-14.
Lin YD, Hsu KL, Wu ET, et al. Autonomic neuropathy precedes cardiovascular dysfunction in rats with diabetes. Eur J Clin Invest. 2008;38(9):607-14.
Lin, Y. D., Hsu, K. L., Wu, E. T., Tsai, M. S., Wang, C. H., Chang, C. Y., & Chang, K. C. (2008). Autonomic neuropathy precedes cardiovascular dysfunction in rats with diabetes. European Journal of Clinical Investigation, 38(9), 607-14. https://doi.org/10.1111/j.1365-2362.2008.01992.x
Lin YD, et al. Autonomic Neuropathy Precedes Cardiovascular Dysfunction in Rats With Diabetes. Eur J Clin Invest. 2008;38(9):607-14. PubMed PMID: 18837735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autonomic neuropathy precedes cardiovascular dysfunction in rats with diabetes. AU - Lin,Y-D, AU - Hsu,K-L, AU - Wu,E-T, AU - Tsai,M-S, AU - Wang,C-H, AU - Chang,C-Y, AU - Chang,K-C, PY - 2008/10/8/pubmed PY - 2008/12/17/medline PY - 2008/10/8/entrez SP - 607 EP - 14 JF - European journal of clinical investigation JO - Eur J Clin Invest VL - 38 IS - 9 N2 - BACKGROUND: Our team previously demonstrated arterial stiffening and cardiac hypertrophy in type 2 diabetic rats at 8 but not 4 weeks after being administered streptozotocin (STZ) and nicotinamide (NA). The present study focused on investigating the effects of type 2 diabetes on cardiac autonomic nerve function in the STZ- and NA-treated animals, using modern spectral estimation technique. DESIGN: An autoregressive process was performed to each detrended signal of heart rate and systolic blood pressure measured in the 4- and 8-week STZ-NA rats with anaesthesia. The power of low-frequency and high-frequency oscillations was automatically quantified with each spectral peak by computing the residuals. The closed-loop baroreflex gain was estimated using the square root of the ratio between heart rate and systolic blood pressure powers in the low-frequency band. RESULTS: Compared with the age-matched controls, both the 4- and 8-week STZ-NA diabetic rats had significantly decreased low-frequency oscillations of heart rate but not systolic blood pressure variability, showing a decline in baroreflex gain (0.451 +/- 0.060 and 0.484 +/- 0.056 vs. 1.196 +/- 0.064 ms mmHg(-1), P < 0.05). On the other hand, the low frequency-high frequency power ratio of the heart period was also diminished in the two diabetic groups, indicating a shift in sympatho-vagal balance of the heart control (0.472 +/- 0.109 and 0.504 +/- 0.090 vs. 1.857 +/- 0.336, P < 0.05). CONCLUSIONS: The cardiac autonomic dysfunction in the absence of any significant changes in vascular dynamics, 4 but not 8 weeks after induction of type 2 diabetes, suggests that the diabetic autonomic neuropathy may precede arterial stiffening and cardiac hypertrophy in the STZ- and NA-treated rats. SN - 1365-2362 UR - https://www.unboundmedicine.com/medline/citation/18837735/Autonomic_neuropathy_precedes_cardiovascular_dysfunction_in_rats_with_diabetes_ L2 - https://doi.org/10.1111/j.1365-2362.2008.01992.x DB - PRIME DP - Unbound Medicine ER -