Tags

Type your tag names separated by a space and hit enter

Gastroesophageal reflux disease (GERD): risk factors, and impact on quality of life-a population-based study.
J Clin Gastroenterol 2009; 43(2):111-7JC

Abstract

BACKGROUND

We aimed to determine the prevalence of gastroesophageal reflux disease (GERD) and associated risk factors, and assess quality of life (QoL) in relation to the frequency and severity of reflux symptoms.

METHODS

A random sample of 1000 residents of Western Sydney were mailed a validated self-report questionnaire. GERD symptoms, risk factors, psychologic distress, QoL, and demographics were measured.

RESULTS

The response rate was 73% (n=672; mean age, 46 y; 52% female). A total of 78 [12%, 95% confidence interval (CI): 9-14] had GERD (at least weekly heartburn and/or acid regurgitation). Independent risk factors for GERD were high cholesterol [odds ratio (OR) =3.28, 95% CI: 1.42-7.57, P=0.005] and current smoker (OR=2.47, 95% CI: 1.07-5.70, P=0.03). Anxiety, depression, and neuroticism were not risk factors. Worse physical functioning was the only QoL domain associated with GERD (OR=0.98, 95% CI: 0.97-0.99, P=0.006). QoL was significantly impaired regardless of the severity of GERD for the QoL domains physical function, body pain, vitality, and social function. The frequency of heartburn and acid regurgitation were not associated with significantly reduced QoL domain scores.

CONCLUSIONS

Cardiac risk factors (high cholesterol and smoking) were independently associated with GERD. Increasing GERD symptom severity is associated with worse QoL scores, whereas GERD symptom frequency did not impact the QoL scores.

Authors+Show Affiliations

School of Public Health, The University of Sydney, Sydney, Australia. eslickg@med.usyd.edu.auNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18838922

Citation

Eslick, Guy D., and Nicholas J. Talley. "Gastroesophageal Reflux Disease (GERD): Risk Factors, and Impact On Quality of Life-a Population-based Study." Journal of Clinical Gastroenterology, vol. 43, no. 2, 2009, pp. 111-7.
Eslick GD, Talley NJ. Gastroesophageal reflux disease (GERD): risk factors, and impact on quality of life-a population-based study. J Clin Gastroenterol. 2009;43(2):111-7.
Eslick, G. D., & Talley, N. J. (2009). Gastroesophageal reflux disease (GERD): risk factors, and impact on quality of life-a population-based study. Journal of Clinical Gastroenterology, 43(2), pp. 111-7. doi:10.1097/MCG.0b013e31815ea27b.
Eslick GD, Talley NJ. Gastroesophageal Reflux Disease (GERD): Risk Factors, and Impact On Quality of Life-a Population-based Study. J Clin Gastroenterol. 2009;43(2):111-7. PubMed PMID: 18838922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroesophageal reflux disease (GERD): risk factors, and impact on quality of life-a population-based study. AU - Eslick,Guy D, AU - Talley,Nicholas J, PY - 2008/10/8/pubmed PY - 2009/4/21/medline PY - 2008/10/8/entrez SP - 111 EP - 7 JF - Journal of clinical gastroenterology JO - J. Clin. Gastroenterol. VL - 43 IS - 2 N2 - BACKGROUND: We aimed to determine the prevalence of gastroesophageal reflux disease (GERD) and associated risk factors, and assess quality of life (QoL) in relation to the frequency and severity of reflux symptoms. METHODS: A random sample of 1000 residents of Western Sydney were mailed a validated self-report questionnaire. GERD symptoms, risk factors, psychologic distress, QoL, and demographics were measured. RESULTS: The response rate was 73% (n=672; mean age, 46 y; 52% female). A total of 78 [12%, 95% confidence interval (CI): 9-14] had GERD (at least weekly heartburn and/or acid regurgitation). Independent risk factors for GERD were high cholesterol [odds ratio (OR) =3.28, 95% CI: 1.42-7.57, P=0.005] and current smoker (OR=2.47, 95% CI: 1.07-5.70, P=0.03). Anxiety, depression, and neuroticism were not risk factors. Worse physical functioning was the only QoL domain associated with GERD (OR=0.98, 95% CI: 0.97-0.99, P=0.006). QoL was significantly impaired regardless of the severity of GERD for the QoL domains physical function, body pain, vitality, and social function. The frequency of heartburn and acid regurgitation were not associated with significantly reduced QoL domain scores. CONCLUSIONS: Cardiac risk factors (high cholesterol and smoking) were independently associated with GERD. Increasing GERD symptom severity is associated with worse QoL scores, whereas GERD symptom frequency did not impact the QoL scores. SN - 1539-2031 UR - https://www.unboundmedicine.com/medline/citation/18838922/Gastroesophageal_reflux_disease__GERD_:_risk_factors_and_impact_on_quality_of_life_a_population_based_study_ L2 - http://Insights.ovid.com/pubmed?pmid=18838922 DB - PRIME DP - Unbound Medicine ER -